The Antimicrobial Resistance Institute of São Paulo (The Aries Project)

• Grant number: 21/10599-3
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• Duration: May 01, 2023 - April 30, 2028
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Arnaldo Lopes Colombo
• Grantee: Arnaldo Lopes Colombo
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Pesquisadores principais: Ana Cristina Gales ; Elbert Einstein Nehrer Macau ; Moacir de Miranda Oliveira Junior ; Nilton Erbet Lincopan Huenuman ; Sergio Schenkman
• Associated researchers: Ademar Arthur Chioro dos Reis ; Adriano Massuda ; Anete Pereira de Souza ; Antonio Carlos Campos Pignatari ; Camila Bertini Martins ; Carlos Magno Castelo Branco Fortaleza ; Christiane de Arruda Rodrigues ; Cláudia Sofia Frias Pinto ; Daielly Melina Nassif Mantovani ; Daniela Goncales Galasse Rando ; Décio Luis Semensatto Junior ; Elize Massard da Fonseca ; Fabio Augusto Faria ; Felipe Mendes Borini ; Flávia Cristina Martins Queiroz Mariano ; Gabriela de Brelaz ; Geórgia Christina Labuto Araújo ; Gustavo Henrique Goldman ; Iran Malavazi ; João Nóbrega de Almeida Júnior ; Lilian Berton ; Luiz Sidney Longo Junior ; Marcos Gonçalves Quiles ; Mirian Chieko Shinzato ; Patricia Sartorelli ; Rodrigo Cayô da Silva ; Simone Georges El Khouri Miraglia ; Suzan Pantaroto de Vasconcellos ; Wagner Luiz Batista ; Welington Luiz de Araújo
• Associated scholarship(s): 23/10416-1 - Use of the CRISPR-Cas12 methodology for the diagnosis of infectious bacteria in a hospital environment, BP.DR

Abstract

Antimicrobial resistance (AMR) has been considered one of the main threats to the human race in the 21st century. We are facing an unstoppable fast-forward instance of Darwinian adaptation through natural selection, in which microbes are constantly evolving to survive antimicrobials. As part of their natural behavior, they adapt continuously. They will succeed unless we develop effective approaches to control and prevent further AMR spread. We propose to establish the Antimicrobial Resistance Institute of São Paulo (ARIES) that will join researchers from 5 universities in São Paulo with experts from public organizations (EMBRAPA, CETESB) and representatives of the Ministry of Agriculture, Livestock and Food Supply, Ministry of Health, Brazilian Health Regulatory Agency (ANVISA) and Pan American Health Organization (PAHO). Working together in a pioneering enterprise, they will fight against AMR implementing the concepts of Global Health and One Health. Mitigation of the AMR threat requires a multidisciplinary approach that recognizes and interferes in the drivers of AMR in the human-animal-environment interface. ARIES will count on five main pillars to achieve our key objectives: 1) Socio-Environmental Observatory and Data Science Center: surveillance of ecosystems involved in the emergence and spread of AMR; 2) Characterization of microbial evolution, mechanisms of AMR and microorganism fitness and pathogenicity; 3) Development and validation of new strategies for control and prevention of AMR in humans, animals, and environment; 4) Translation of the successful initiatives to Business and Public Health Policies; and 5) Diffusion of ARIES - Knowledge in connection with Society, Education and Dissemination. ARIES will not only contribute to elaborate a more sophisticated and comprehensive surveillance system able to early detect the emergence of AMR in the context of One Health, but also generate new strategies to respond, contain, and prevent the resistant infections across healthcare settings, food, and communities. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GUIMARAES, TACIANA G. S.; BARROS, LUCELIA A.; SILVA, RICARDO SANTOS; GONZALEZ, MARIO H.; CARRILHO, ELMA N. V. M.; LABUTO, GEORGIA. Synthesis and characterization of biochars modified with natural deep eutectic solvent (NADES) for dipyrone removal from aqueous medium. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 35, p. 18-pg., 2023-10-01. (22/06823-8, 21/06471-1, 21/14759-5, 21/14791-6, 20/12263-0, 21/10599-3, 20/14419-7, 22/08358-0)