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Evaluation of Strongyloides venezuelensis heterologous antigen in the immunodiagnosis of human Strongyloidiasis: a study between Brazil, Peru and Portugal

Grant number: 22/02401-1
Support Opportunities:Regular Research Grants
Duration: April 01, 2023 - March 31, 2025
Field of knowledge:Biological Sciences - Parasitology - Helminthology of Parasites
Principal Investigator:Fabiana Martins de Paula
Grantee:Fabiana Martins de Paula
Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated researchers: Dirce Mary Correia Lima Meisel ; Gisele Monteiro ; Guilherme Rabelo Coelho ; Marcelo Andreetta Corral ; Marco Canales-Ramos ; Maria Angelica Terashima Iwashita ; Pedro Manuel Machado Carlos Ferreira ; Ronaldo Cesar Borges Cryschek ; Silvana Maria Duarte Belo ; William de Castro Borges ; William Henry Roldán Gonzáles

Abstract

Strongyloidiasis is a parasitic infection caused by the nematode Strongyloides stercoralis, has a worldwide distribution and is higher prevalent in tropical and subtropical regions. Severe forms of this helminthiasis, hyperinfection syndrome and/or disseminated disease, have high mortality and constitute an important public health problem in areas where the infection is endemic. The definitive diagnosis is based on parasitological examination, mainly on the visualization of larvae in the feces, which has low sensitivity. Immunological techniques by detecting antibodies against the parasite are an important alternative to parasitological diagnosis, as they manage to overcome the low sensitivity of fecal exams. However, the main limitation of immunodiagnosis is the difficulty in obtaining parasite antigens. Thus, several authors have suggested the use of heterologous antigens from other Strongyloides species, non-infectious for humans and easily obtainable, such as Strongyloides venezuelensis. Although the literature is vast and presents promising results, the use of these heterologous antigens applied to the serological diagnosis of human strongyloidiasis has been restricted to Brazil. In this context, the present study aims to evaluate the antigen recognition of protein preparations from S. venezuelensis infective larvae by antibodies present in serum samples from individuals from Brazil, Peru and Portugal. (AU)

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