Vaccine immunogenicity in kidney transplant patients: evaluation of T and B lymphocyte humoral response

• Grant number: 22/16391-8
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2023
• End date: May 31, 2025
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Luiz Sergio Fonseca de Azevedo
• Grantee: Luiz Sergio Fonseca de Azevedo
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Gil Benard ; Juliana Ruiz Fernandes ; Laís Teodoro da Silva ; Marcelo Paes Menezes Filho ; Telma Miyuki Oshiro Sumida

Abstract

Infectious diseases are one of the main causes of morbidity and mortality in patients with kidney disease, including kidney transplanted recipients. The concern with the immunization of this population is even more relevant, the use of immunosuppressive treatment can lead to less efficient immune responses, with lower seroconversion rates, lower antibody titers andshorter duration of protection, compared to healthy individuals. In this context,the present study aims to evaluate the cellular and humoral response to antiSARS-CoV-2 immunization in kidney transplanted patients compared to healthy individuals, and also analyze possible differences in T and B lymphocytes, antibody responses of individuals transplanted using different immunosuppressive medications. (AU)