Phosphine Ru(II) complexes with naphthoquinones and derivatives: potential anticancer, estudies in vitro and in vivo

• Grant number: 23/02475-8
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2023
• End date: June 30, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Alzir Azevedo Batista
• Grantee: Alzir Azevedo Batista
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated scholarship(s): 25/01813-2 - "Ru(II) complexes containing phytocompounds or mercaptes as ligands: A rational strategy for obtaining potential metallopharmaceuticals", BP.DD

Abstract

Bioinorganic, together with medicinal chemistry, has benefited from the use of metallopharmaceuticals as drugs and therapeutic agents. In this context, several researchers have been dedicated to the synthetic chemistry of coordination compounds with medicinal application, searching for new compounds with biological activity and modeling the existing ones to reduce the their side effects. Among those studied in the literature, ruthenium compounds stand out, which have shown positive results in terms of anticancer and antimetastatic activity. Thus, this project is based on the synthesis and characterization of complexes, which may have the following structural formulas: [Ru(L)(dppe)(bipy)]PF6, [Ru(L)(dppb)(bipy)]PF6, [Ru(L)(DPEPhos)(bipy)]PF6, where L = lausone derivatives, bipy = 2,2'-bipyridine, dppe = 1,2'-bis(diphenylphosphine)ethane and DPEPhos = Bis[2-(diphenylphosphine) phenyl]ether. The complexes will be characterized by the following techniques: elemental analysis, conductivity, absorption spectroscopy in the infrared and ultraviolet and visible regions, cyclic and square wave voltammetry, nuclear magnetic resonance of 31P{1H}, 1H and 13C and X-ray diffraction. The newly synthesized complexes will be evaluated for their cytotoxic activities in prostate (DU-145), lung (A549), breast (MCF-7 and MDA-MB-231) and non-tumor breast (MCF-10A) cancer cell lines. ) and which ones present better results submitted to new biological studies. The results through chemical and biological data will provide subsidies to formulate a possible mechanism of action for the complexes. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, NADIJA N. P.; PALMEIRA-MELLO, MARCOS V.; ACESIO, NATHALIA O.; MORAES, CARLOS A. F.; HONORATO, JOAO; CASTELLANO, EDUARDO E.; TAVARES, DENISE C.; OLIVEIRA, KATIA M.; BATISTA, ALZIR A.. Ru(ii)-diphosphine/N,S-mercapto complexes and their anti-melanoma properties. DALTON TRANSACTIONS, v. N/A, p. 11-pg., 2024-11-14. (17/15850-0, 23/02475-8, 21/01787-0)

PALMEIRA-MELLO, MARCOS, V; TEIXEIRA, TAMARA; DE MELO, MATHEUS REIS SANTOS; NICOLELLA, HELOIZA DINIZ; DUTRA, JOCELY L.; COMINETTI, MARCIA R.; ROCHA, FILLIPE VIEIRA; TAVARES, DENISE CRISPIM; BATISTA, ALZIR A.. Ruthenium(II)-mercapto complexes induce cell damage via apoptosis pathway on ovarian cancer cells. Journal of Inorganic Biochemistry, v. 265, p. 10-pg., 2025-01-04. (22/02876-0, 21/01787-0, 23/02475-8)

DUTRA, JOCELY L.; HONORATO, JOAO; GRAMINHA, ANGELICA; MORAES, CARLOS ANDRE F.; DE OLIVEIRA, KLEBER T.; COMINETTI, MARCIA R.; CASTELLANO, EDUARDO E.; BATISTA, ALZIR A.. Pd(ii)/diphosphine/curcumin complexes as potential anticancer agents. DALTON TRANSACTIONS, v. 53, n. 47, p. 15-pg., 2024-06-14. (21/02522-0, 17/15850-0, 21/04876-4, 23/02475-8)

TEIXEIRA, TAMARA; PALMEIRA-MELLO, MARCOS V.; MACHADO, PEDRO HENRIQUE; MORAES, CARLOS A. F.; PINTO, CAMILA; COSTA, RAYANE C.; BADARO, WLADIMIR; GOMES NETO, JOSE A.; ELLENA, JAVIER; VIEIRA ROCHA, FILLIPE; et al. Ru(II)-Fenamic-Based Complexes as Promising Human Ovarian Antitumor Agents: DNA Interaction, Cellular Uptake, and Three-Dimensional Spheroid Models. Inorganic Chemistry, v. N/A, p. 12-pg., 2025-02-18. (24/02879-4, 21/01787-0, 22/14041-0, 23/02475-8)

PALMEIRA-MELLO, MARCOS V.; MESDOM, PIERRE; BURCKEL, PIERRE; HIDALGO, SAMIA; BLACQUE, OLIVIER; GASSER, GILLES; BATISTA, ALZIR A.. Cytotoxic Ruthenium(II)-Diphosphine Complexes Affect the Mitochondrial Respiration of Lung Cancer Cells. CHEMBIOCHEM, v. 26, n. 2, p. 14-pg., 2025-01-10. (22/02876-0, 21/01787-0, 22/09971-8, 23/02475-8)

PALMEIRA-MELLO, MARCOS V.; COSTA, ANALU R.; DE OLIVEIRA, LETICIA P.; BLACQUE, OLIVIER; GASSER, GILLES; BATISTA, ALZIR A.. Exploring the potential of ruthenium(ii)-phosphine-mercapto complexes as new anticancer agents. DALTON TRANSACTIONS, v. 53, n. 26, p. 14-pg., 2024-06-19. (22/09971-8, 23/02475-8, 21/01787-0)