Stabilization and encapsulation of natural colorants and application in the development of packaging and cosmetics

• Grant number: 23/01368-3
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2023
• End date: December 31, 2025
• Field of knowledge: Engineering - Chemical Engineering
• Agreement: CNPq
• Principal Investigator: Valéria de Carvalho Santos Ebinuma
• Grantee: Valéria de Carvalho Santos Ebinuma
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated research grant: 21/06686-8 - Biotechnological process for the development of natural colorants from microbial sources for industrial application: phase II, AP.BIOEN.JP2
• Associated research grant(s): 24/09428-8 - I Brazilian Congress of Industrial Biotechnology, AR.BR
• Associated scholarship(s): 24/16647-8 - Production, stabilization and encapsulation of natural colorants and application in the development of packaging and cosmetics, BP.JD; 23/10479-3 - Stabilization and encapsulation of natural colorants and application in the development of packaging and cosmetics, BP.JD

Abstract

Consumers are increasingly concerned about their health and the composition of their food and personal care products. For this reason, the pharmaceutical and food industries have replaced synthetic colorants with natural ones, which, in addition to pleasing the public, can confer advantages to materials and foods, attributing them antioxidant and antimicrobial action. In this context, this project aims to develop functional creams and packaging with natural colorants that have functional advantages over similar ones on the market, are safe, have sustainable production and composition with natural ingredients. Additionally, they must be economically viable and with the possibility of insertion in the Brazilian market. To do so, first, we will evaluate the stability of different natural colorants of azafilones and carotenoids to select the best compound for application. For creams, we will check the stability of colorants in mixtures of fatty acids and surfactants to select compatible components for this purpose. Then, we will define emulsion compositions for the production of colorant creams, which will have their stability, safety and antioxidant action evaluated. For packaging (biodegradable films), we will first encapsulate the colorants in maltodextrin and chitosan and then develop biodegradable films with chitosan for use as food packaging. The formed biodegradable films will be evaluated for their strength, durability, antioxidant and antimicrobial properties, food preservation potential and organoleptic changes in butter and meat. After developing two satisfactory products, we will also carry out a technical-economic evaluation and market research to assess their economic viability and market insertion potential. Therefore, the project foresees the complete development of two products using natural colorants. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MUSSAGY, CASSAMO U.; DIAS, ANA C. R. V.; SANTOS-EBINUMA, VALERIA C.; SADEK, M. SHAABAN; AHMAD, MUSHTAQ; DE ANDRADE, CLEVERTON R.; HADDAD, FELIPE F.; DOS SANTOS, JEAN L.; SCARIM, CAUE B.; PEREIRA, JORGE F. B.; et al. Is the carotenoid production from Phaffia rhodozyma yeast genuinely sustainable? a comprehensive analysis of biocompatibility, environmental assessment, and techno-economic constraints. Bioresource Technology, v. 397, p. 12-pg., 2024-02-19. (21/06686-8, 23/01368-3)

FREITAS, AMANDA NOLI; REMONATTO, DANIELA; MIOTTI JR, RODNEY HELDER; DO NASCIMENTO, JOAO FRANCISCO CABRAL; MOURA, ADRIANA CANDIDO DA SILVA; EBINUMA, VALERIA DE CARVALHO SANTOS; DE PAULA, ARIELA VELOSO. Adsorption of extracellular lipase in a packed-bed reactor: an alternative immobilization approach. Bioprocess and Biosystems Engineering, v. 47, n. 10, p. 15-pg., 2024-08-05. (21/13147-6, 23/01368-3, 21/06686-8, 20/09592-1)

DE OLIVEIRA, F.; DIAS, A. C.; SANCHEZ-MUNOZ, S.; BALBINO, T. R.; SANTOS-EBINUMA, V. C.; DA SILVA, S. S.. Sustainability feasibility of fungi-based biocolorants by biotechnological routes. CHEMICAL ENGINEERING JOURNAL, v. 494, p. 18-pg., 2024-06-19. (21/06686-8, 23/01368-3, 21/09175-4, 22/14603-8)

GALVAN, KARINA LIZZETH PEDRAZA; VERISSISMO, NATHALIA VIEIRA PORHIRIO; SANTANA, JAMILLE SANTOS; LEMOS, PAULO VITOR FRANCA; DE SOUZA, CAROLINA OLIVEIRA; CARDOSO, LUCAS GUIMARAES; ASSIS, DENILSON DE JESUS; MARCELINO, HENRIQUE RODRIGUES; DE OLIVEIRA, THAMILA THALLINE BATISTA; BIASOTO, ALINE TELLES CAMARA; et al. Encapsulation of polyketide colorants in chitosan and maltodextrin microparticles. International Journal of Biological Macromolecules, v. 269, p. 13-pg., 2024-05-10. (21/06686-8, 23/01368-3, 23/10479-3)

VERISSIMO, NATHALIA VIEIRA PORPHIRIO; MUSSAGY, CASSAMO USEMANE; BENTO, HEITOR BUZETTI SIMOES; PEREIRA, JORGE FERNANDO BRANDAO; SANTOS-EBINUMA, VALERIA DE CARVALHO. Ionic liquids and deep eutectic solvents for the stabilization of biopharmaceuticals: A review. BIOTECHNOLOGY ADVANCES, v. 71, p. 22-pg., 2024-01-16. (21/06686-8, 23/01368-3, 18/06908-8, 23/10479-3)

MAGALHAES, FLAVIA F.; NEVES, MARCIA C.; PEDRO, AUGUSTO Q.; FREIRE, MARA G.; SANTOS-EBINUMA, VALERIA C.; TAVARES, ANA P. M.. Recombinant laccase biosynthesis for efficient polydopamine coating. Biochemical Engineering Journal, v. 212, p. 11-pg., 2024-09-14. (21/06686-8, 23/01368-3)