Abstract
The project is a joint initiative of psychology, dentistry, and medical researchers. Objectives: Our main objective is to carry out research on twins' behavior related to health and well-being from an ontogenetic perspective (P1-P14). Methods: Sociodemographic data and self-report measures, behavioral data, and physical and physiological indicators will be collected. Salivary biomarkers (microbiome and metabolomics) and their correlations with clinical outcomes will be analyzed. Expected results: We expect to expand and organize the database of the USP Twin Panel (P1) and the Twin Birth Registry of the FMUSP's Hospital das Clinicas and to carry out analyzes of the epidemiological profile and outcomes associated with twin pregnancies (P2). The genetic profile of the participants will be determined (P3). We will present results regarding parenting styles (P4), physical and behavioral development, and stress reactions of twin children as a function of zygosity and differences in fetal development (P5, P6). Descriptions of prosodic contours of human and non-human infants cry (P7) will be presented. Additionally, we will present results on relationship styles, cooperation and competition (P8) and on anxiety in a potentially stressful situation, i.e., during dental treatment (P9). Finally, we will present data on the influence of genetic and environmental variables on the occurrence of oral health problems, the efficacy of different restorative treatments, and interventions aimed at promoting appropriate oral health behaviors, and their correlations with the dynamics of salivary biomarkers (P10-P13). We conclude with the presentation of the Clinical Branch of the USP Twin Panel (P14), and of the Educational Branch of the USP Twin Panel (P15). (AU)
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