Development of polysaccharide membrane containing plant extract for pressure Ulcer treatment

• Grant number: 22/06228-2
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2023
• End date: August 31, 2025
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Priscila Gava Mazzola
• Grantee: Priscila Gava Mazzola
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Érica Mendes dos Santos ; Janaína Artem Ataide
• Associated research grant(s): 24/02161-6 - Development of membranes containing k-carrageenan microspheres loaded with açaí extract, AP.R; 24/02159-1 - Ultra-mesh: upgrading layers of treatment with refined applications of membranes, extracts, and saccharides for healing, AP.R SPRINT
• Associated scholarship(s): 24/17929-7 - Maintenance and operation of the texture meter and its accessories, BP.TT; 24/15004-6 - Development and validation of the method for HPLC, BP.TT

Abstract

Pressure ulcers are injuries to the skin or tissue that usually occur as a result of other diseases that lead to the patient's loss of mobility, which is bedridden, leading to pressure in a specific area and decreased blood circulation. These lesions have different levels of depth of damage caused to the skin, which can affect muscles and bones. This problem causes serious pain, impairing the quality of life of patients in addition to increasing the mortality rate. In this context, it is essential that new formulations for topical use be developed for the prevention and treatment of pressure ulcers, aimed at relieving pain, preventing microbiological contamination, in addition to a more efficient and low-cost healing. Therefore, the present project proposes the development of a membrane for the healing of pressure ulcers, using carrageenan and açaí seed extract, natural raw materials with great healing potential, but little explored so far. In addition to this fact, silicone will be used in the formulation that allows it to adhere to the skin and not the wound, which promotes greater relief to the patient, in addition to containing an agent with antimicrobial activity, which will avoid microbiological contamination. This formulation will be developed with pain relief and functional effects in mind, increasing patient comfort. The developed membrane will be analyzed regarding its appearance, morphology, physicochemical and microbiological properties, mucoadhesiveness, cytotoxicity and healing potential. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOS SANTOS, ERICA MENDES; GASPAR, RITA CAIADO; DE CEULAER, FEMKE; CHIU, HAO-CHUN; DE WEVER, PIETER; MAZZOLA, PRISCILA GAVA; FARDIM, PEDRO. Tailored alginate sponges loaded with x-carrageenan beads for controlled release of curcumin. International Journal of Biological Macromolecules, v. 280, p. 9-pg., 2024-09-23. (21/14698-6, 24/02159-1, 22/06228-2, 20/11333-4)

DA COSTA-OLIVEIRA, CLAUDETE; PEREIRA, MICHELE LAFAYETTE; DE CARVALHO, NICOLE FERRARI; SILVERIO, LUIZA APARECIDA LUNA; RAMOS, YGOR JESSE; MAZZOLA, PRISCILA GAVA. Exploring the Significance of Pharmaceutical Care in Mental Health: A Spotlight on Cannabis. PHARMACY, v. 12, n. 4, p. 20-pg., 2024-08-01. (22/06228-2, 22/11241-8)

FAVA, ANA LAURA MASQUETTI; DE SOUZA, CINTHIA MADEIRA; DOS SANTOS, ERICA MENDES; SILVERIO, LUIZA APARECIDA LUNA; ATAIDE, JANAINA ARTEM; PAIVA-SANTOS, ANA CLAUDIA; COSTA, JOSE LUIZ; DE MELO, DANIELA OLIVEIRA; MAZZOLA, PRISCILA GAVA. Evidence of Cannabidiol Effectiveness Associated or Not with Tetrahydrocannabinol in Topical Administration: A Scope Review. PHARMACEUTICALS, v. 17, n. 6, p. 26-pg., 2024-06-01. (22/11241-8, 20/11333-4, 18/06475-4, 23/07323-1, 22/06228-2)

DOS SANTOS, ERICA MENDES; DE MACEDO, LUCAS MALVEZZI; ATAIDE, JANAINA ARTEM; DELAFIORI, JEANY; GUARNIERI, JOAO PAULO DE OLIVEIRA; ROSA, PAULO CESAR PIRES; RUIZ, ANA LUCIA TASCA GOIS; LANCELLOTTI, MARCELO; JOZALA, ANGELA FAUSTINO; CATHARINO, RODRIGO RAMOS; et al. Antioxidant, antimicrobial and healing properties of an extract from coffee pulp for the development of a phytocosmetic. SCIENTIFIC REPORTS, v. 14, n. 1, p. 11-pg., 2024-02-23. (20/11333-4, 18/06475-4, 22/06228-2, 14/50938-8, 19/05718-3)