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Evaluation of intestinal permeability, dysbiosis and expression of microRNAs in patients with Inflammatory Bowel Disease (IBD) and association with Non-Alcoholic Fatty Liver Disease (NAFLD)

Abstract

The intestinal microbiota is known to provide several benefits to its host, due to the symbiotic interaction established between them. An imbalance between beneficial and pathogenic bacteria in the intestine, known as dysbiosis, can result in the development of diseases such as diabetes, obesity, liver diseases, such as Non-Alcoholic Fatty Liver Disease (NAFLD), and the Inflammatory Bowel Disease (IBD), considered one of the main diseases related to dysbiosis, which includes Crohn's Disease and Ulcerative Colitis. Several studies show that around 33% of IBD patients develop NAFLD, due to the pathophysiological mechanisms present in both diseases. NAFLD is a chronic disease, characterized by excessive hepatic fat deposits, and just like in IBD, studies indicate that changes in the intestinal permeability and intestinal microbiota may have an important role in the development of this disease. In addition to dysbiosis, microRNAs (miRNAs) have also recently been associated with the evolutionary etiology of IBD and NAFLD, as well as in the participation of modulation of the intestinal microbiota and induction of dysbiosis, while the microbiota can regulate the expression of miRNAs and thus alter intestinal homeostasis. Based on this, the present study aims to analyze the profile of the microRNAs, intestinal permeability and the presence of dysbiosis of patients with IBD and compare findings between groups IBD with NAFLD and IBD without NAFLD. (AU)

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