Synthesis, characterization, and solubility study of new crystalline forms of antineoplastic agents

• Grant number: 23/01502-1
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2023
• End date: October 31, 2025
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Agreement: CNPq
• Principal Investigator: Fabio Furlan Ferreira
• Grantee: Fabio Furlan Ferreira
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated research grant: 21/03640-7 - Synthesis and investigation of new crystalline forms of antineoplastic agents, AP.R
• Associated scholarship(s): 23/14132-8 - Synthesis, characterization, and solubility Study of new crystalline forms of antineoplastic agents, BP.JD

Abstract

Neoplasms have been the leading cause of most deaths recorded annually worldwide. Scientists are engaged in research to continuously improve the treatment of the most diverse types of cancer. Therefore, the main objective of this project is to optimize the performance of the drug candidate LASSBio-1735, both through the development of new crystalline forms and through its controlled release. The crystal structure of LASSBio-1735 - an N-acylhydrazone derivative that exhibited in vitro antiproliferative activity against HL-60 (human leukemia), SF-295 (human glioblastoma), MDA-MB435 tumor cells (melanoma) and HCT-8 (ileocecal adenocarcinoma) - which was determined by our research group, will be the basis for the synthesis and investigation of the physical-chemical properties of the new crystalline forms (salts, hydrates, solvates and/or co-crystals). It is extremely important to study the interaction of the new crystalline forms obtained with the biological system; therefore, cell viability will be evaluated by MTT in neoplastic cell lines compared to healthy cell lines, as well as the evaluation of hemolytic activity. The antineoplastic action will be evaluated based on the relationship between the gene expression of inflammatory markers and oxidative stress, tumor growth, and toxicity assessment. Balb/c mice will be used and inoculated with Ehrlich tumor cells for this. These animals will be treated in different periods and groups. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CHAGAS, CAMILA; MANSANO, JAQUELINE VITAL; DA SILVA, EMERSON BARBOSA; PETRI, GIULIANA; REIS, BEATRIZ DA COSTA AGUIAR ALVES; SCHUMACHER, MARIA LUCIA; HADDAD, PAULA SILVIA; PEREIRA, EDIMAR CRISTIANO; BRITOS, TATIANE NASSAR; BARREIRO, ELIEZER J.; et al. In vitro results with minimal blood toxicity of a combretastatin A4 analogue. INVESTIGATIONAL NEW DRUGS, v. 42, n. 3, p. 8-pg., 2024-05-17. (23/01502-1, 18/12219-0)

DE ASSIS, RENAN GABRIEL; DE OLIVEIRA JUNIOR, MARCOS; ESCOTE, MARCIA TSUYAMA; PINHEIRO, CARLOS BASILIO; ACUNA, JOSE JAVIER SAEZ; FERREIRA, FABIO FURLAN; PEDROZA, LUANA SUCUPIRA; BROCHSZTAIN, SERGIO; DE QUEIROZ, THIAGO BRANQUINHO. Preparation and Characterization of a Disilylated Naphthalenediimide Molecular Crystal: Perspectives for Organosilica Mesoporous Materials. ACS APPLIED ENGINEERING MATERIALS, v. 2, n. 7, p. 11-pg., 2024-07-08. (23/01502-1, 21/07694-4, 13/07793-6, 17/10292-0, 23/08771-8, 22/02974-1, 20/13466-1)

ROMERO, NATALI; KERGARAVAT, SILVINA, V; REGALDO, LUCIANA; HERNANDEZ, SILVIA R.; SEABRA, AMEDEA B.; FERREIRA, FABIO F.; LOURENCO, ISABELLA M.; CASTRO, GUILLERMO R.; GAGNETEN, ANA M.. Multiple physiological response analyses of Chlorella vulgaris exposed to silver nanoparticles, ciprofloxacin, and their combination. Environmental Toxicology and Chemistry, v. 44, n. 4, p. 16-pg., 2025-03-04. (24/13717-5, 23/01502-1)

OLIVEIRA, WESLEY K. C.; DINIZ, RAISA M. C. S.; RODRIGUES, JESSICAA. O.; DE SOUSA, FRANCISCO F.; DOS SANTOS, CLENILTON C.; SINFRONIO, FRANCISCO S. M.; FERREIRA, FABIO F.; DA SILVA FILHO, JOSE G.; DE MENEZES, ALAN S.. Spherulite-like Ni(II)(l-glutaminatoH₂O)₂ Complex: Morphological Microstructure, DFT-Assisted Crystal Structure Determination, and Vibrational Analysis. ACS OMEGA, v. 10, n. 9, p. 11-pg., 2025-03-02. (23/01502-1, 23/09820-2)

SCHUMACHER, MARIA L.; BRITOS, TATIANE N.; FONSECA, FERNANDO L. A.; FERREIRA, FABIO F.; FEDER, DAVID; FRATINI, PAULA; PETRI, GIULIANA; HADDAD, PAULA S.. Superparamagnetic nanoparticles as potential drug delivery systems for the treatment of Duchenne muscular dystrophy. NANOSCALE, v. 17, n. 7, p. 16-pg., 2024-12-19. (22/03647-4, 23/01502-1)