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Biosensing and delivery point-of-care technologies based on microneedles to improve healthcare testing and treatments

Grant number: 22/14753-0
Support Opportunities:Research Projects - Thematic Grants
Duration: December 01, 2023 - November 30, 2028
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Convênio/Acordo: Netherlands Organisation for Scientific Research (NWO)
Principal Investigator:Wendel Andrade Alves
Grantee:Wendel Andrade Alves
Principal researcher abroad: Marinus Isaäk de Jonge
Institution abroad: Radboud University Medical Center (Radboudumc), Netherlands
Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Pesquisadores principais:
Daniele Ribeiro de Araujo ; Silvia Beatriz Boscardin
Associated researchers: Ana Cristina Honorato de Castro ; Ana Iochabel Soares Moretti ; Andrea Maria Aguilar ; Bernardus Hendrikus van Oorschot ; Cacilda da Silva Souza ; Daniela Santoro Rosa ; Dominique Mombrú ; Edecio Cunha Neto ; Guilherme Mattos Jardim Costa ; Helder Takashi Imoto Nakaya ; Johannes Petrus Maria Koenen ; Jorge Elias Kalil Filho ; Jose Eduardo Ulloa Rojas ; Lauro Tatsuo Kubota ; Lidia Maria de Andrade ; Mariano Romero Olivera ; Vivian Leite de Oliveira

Abstract

Microneedles (MNs) form a safe and non-invasive drug-delivery platform for topic and systemic applications. Biocompatibility, easy application, improved efficiency-controlled release, and low concentrations needed are among the main benefits of the technology. Technologies based on MNs can increase the population's access to cutting-edge therapies through reduced costs and increase the well-being, successful diagnosis, prognosis, and consequent treatment adherence of patients with chronic diseases due to reduced pain, increased comfort, and reduced side effects. Recent studies from members of this consortium showed how the mechanical properties of polymeric MNs affect the release, improving penetration and flow of hydrophilic drugs for topical use1. We propose to explore this technology by developing novel transdermal delivery and biosensing tools for healthcare applications. We plan to use polymeric MN systems combined with monoclonal antibodies to validate: (1) Transdermal delivery tools for skin cancer therapy, vaccine delivery using monoclonal antibodies, and targeted therapies for psoriasis; (2) Transdermal biosensing tools to detect biomarkers for prognostic and diagnostic of psoriasis and infectious diseases via the construction of electrochemical lateral flow assay MN-sensor systems. In this consortium, we propose to explore different blends of polymers to create customized constructions of MNs as innovative treatment approaches for healthcare applications. (AU)

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