Nitric oxide releasing hydrogels and vascular prosthesis for cardiovascular applications

• Grant number: 22/14645-2
• Support Opportunities: Research Projects - Thematic Grants
• Start date: January 01, 2024
• End date: December 31, 2028
• Field of knowledge: Interdisciplinary Subjects
• Agreement: Netherlands Organisation for Scientific Research (NWO)
• Principal Investigator: Marcelo Ganzarolli de Oliveira
• Grantee: Marcelo Ganzarolli de Oliveira
• Principal researcher abroad: Patricia Dankers
• Institution abroad: Eindhoven University of Technology (TU/e), Netherlands
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Pesquisadores principais: Amedea Barozzi Seabra ; Andrei Carvalho Sposito
• Associated researchers: Ana Luíza Garcia Millás Massaguer ; Anthal Smits ; Julieta Irene Paez
• Associated scholarship(s): 25/00254-0 - Evaluation of the efficacy of topical/injectable hydrogels in attenuating cardiomyocyte ischaemia and reperfusion injury resulting from temporary coronary artery occlusion in an ex-vivo model, BP.TT; 24/19768-0 - Development of structural models for 3D printing of cardiovascular devices, BP.IC; 24/20778-0 - Alginate-based biomaterials for nitric oxide delivery, BP.IC; + associated scholarships 23/16363-7 - Duo-gasotransmitters for biomedical applications: bioformulation of nanoparticles containing Aspirin-NOSH, BP.PD; 24/04079-5 - Nanocomposite biomaterials for sustained release of nitric oxide: modeling and optimization of personalized platforms changing biomedical applications, BP.PD; 24/08075-4 - 3D-printable nitric oxide-releasing hybrid hydrogels for the treatment of myocardial infraction, BP.PD; 24/08081-4 - 3D-printable nitric oxide-releasing absorbable stents, BP.PD; 24/08167-6 - Evaluation of the efficacy of topical/injectable hydrogels in attenuating cardiomyocyte ischaemia and reperfusion injury resulting from temporary coronary artery occlusion in an ex-vivo model, BP.TT - associated scholarships

Abstract

Acute and chronic coronary artery diseases are leading causes of deaths worldwide, demanding new advanced healthcare strategies to mitigate this risk, including the development of materials and inter/trans-disciplinary approaches to treat coronary artery occlusion or stenosis. Hence, the main aim of this project is the development of new polymeric biomaterials for applications in the field of cardiovascular regenerative medicine, including a) stimuli-responsive hydrogels capable of undergoing in situ gelation and promoting the dual delivery of proteins and nitric oxide as therapeutics after topical application, and b) photocurable and bioresorbable nitric oxide-releasing polyesters and hydrogels for the 3D printing of polymeric intracoronary stents and vascular prosthesis. The methodology will include the synthesis and characterization of the responsive polymeric materials and the evaluation of their efficacy and beneficial actions in vitro, in vivo and ex-vivo models. The consolidated experience of the research team, which combines backgrounds in chemistry, materials science, biomedical engineering, and medicine, will be crucial to achieving this goal. We envision that the proposed inter/trans-disciplinary approach and the new biomaterials to be developed will bring significant advances in the rapidly expanding field of regenerative cardiovascular applications, to either attenuate the lesions due to myocardial infarction (MI) or regenerate the damaged heart after MI. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PIERETTI, JOANA C.; HORNE, THAISSA L.; GARCIA-VILLASANTE, NATALIA; SEABRA, AMEDEA B.; MUNTANE, JORDI. Zinc-Based Nanoparticles, but Not Silicon-Based Nanoparticles, Accumulate in Mitochondria and Promote Cell Death in Liver Cancer Cells. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 19, p. 12-pg., 2024-01-01. (21/12705-5, 20/03646-2, 22/14645-2)

DOS REIS, ROBERTA ALBINO; SARKAR, ISHANI; RODRIGUES, MAIARA GONCALVES; MATSON, JOHN B.; SEABRA, AMEDEA BAROZZI; KASHFI, KHOSROW. NO- and H2S-releasing nanomaterials: A crosstalk signaling pathway in cancer. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 151, p. 14-pg., 2024-09-05. (22/00321-0, 22/14645-2, 23/16363-7)

FREIRE, BRUNA MOREIRA; LANGE, CAMILA NEVES; AUGUSTO, CAROLINE CRISTINE; ONWUATU, FERNANDA RIBEIRO; RODRIGUES, GUSTAVO DELL'ARNO PRINCIPE; PIERETTI, JOANA CLAUDIO; SEABRA, AMEDEA BAROZZI; BATISTA, BRUNO LEMOS. Foliar Application of SeNPs for Rice Biofortification: a Comparative Study with Selenite and Speciation Assessment. ACS AGRICULTURAL SCIENCE & TECHNOLOGY, v. 5, n. 1, p. 14-pg., 2024-12-17. (16/10060-9, 22/14645-2, 20/00284-2, 22/04254-6, 14/05151-0)

PAGANOTTI, ANDRE; DE FREITAS, CAROLINA CUNHA; PEREIRA, RONEY H.; VITAL, VITOR GONCALVES; PAIVA, GIOVANNA S. M.; DE LIMA, LUCAS F.; DA SILVA, LEONARDO LONGUINI; TEODOROV, ELIZABETH; DA SILVA, RICARDO A. GALDINO; DE VASCONCELLOS, SUZAN PANTAROTO; et al. Biogenic CuO nanoparticles from Camellia sinensis and Pimpinella anisum plant extracts and their role as antimicrobial agents. PLANT NANO BIOLOGY, v. 11, p. 14-pg., 2025-01-25. (22/05498-6, 23/12466-6, 22/14645-2, 24/12112-2, 22/04262-9)

DE ALMEIDA, HERLLAN VIEIRA; DA SILVA, LAURA CAETANO ESCOBAR; DE OLIVEIRA, MARCELO GANZAROLLI. Nitric oxide-releasing photocrosslinked chitosan cryogels. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 146, p. 10-pg., 2024-04-06. (16/02414-5, 18/14142-5, 22/14645-2)

TORTELLA FUENTES, GONZALO; FINCHEIRA, PAOLA; RUBILAR, OLGA; LEIVA, SEBASTIAN; FERNANDEZ, IVETTE; SCHOEBITZ, MAURICIO; PELEGRINO, MILENA T.; PAGANOTTI, ANDRE; DOS REIS, ROBERTA ALBINO; SEABRA, AMEDEA B.. Nanoparticle-Based Nitric Oxide Donors: Exploring Their Antimicrobial and Anti-Biofilm Capabilities. ANTIBIOTICS-BASEL, v. 13, n. 11, p. 22-pg., 2024-11-01. (22/14645-2, 23/16363-7, 23/12466-6)

MARIANO, MARCOS; NASERI, NARGES; NASCIMENTO, DIEGO MAGALHAES; FRANQUI, LIDIANE; SEABRA, AMEDEA BAROZZI; MATHEW, AJI P.; BERNARDES, JULIANA SILVA. Calcium Cross-Linked Cellulose Nanofibrils: Hydrogel Desing for Local and Controlled Nitric Oxide Release. ACS APPLIED BIO MATERIALS, v. N/A, p. 11-pg., 2024-11-20. (16/22954-4, 16/04514-7, 22/14645-2)

DE ALMEIDA, HERLLAN V.; BOMEDIANO, MATEUS P.; CATORI, DANIELE M.; SILVA, ELIZAURA H. C.; DE OLIVEIRA, MARCELO G.. Integrating 3D printing of biomaterials with nitric oxide release. BIOMATERIALS SCIENCE, v. 13, n. 4, p. 17-pg., 2025-01-07. (16/02414-5, 22/14645-2, 22/13352-1)