Sub3DSkin: Dermal substitute & 3D model for diabetic chronic skin wounds

• Grant number: 22/14725-6
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2024
• End date: March 31, 2028
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Agreement: Netherlands Organisation for Scientific Research (NWO)
• Principal Investigator: Ana Carolina Migliorini Figueira
• Grantee: Ana Carolina Migliorini Figueira
• Principal researcher abroad: Willeke Daamen
• Institution abroad: Radboud University Medical Center (Radboudumc) , Netherlands
• Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Campinas , SP, Brazil
• City of the host institution: Campinas
• Associated researchers: Francisco de Assis Rocha Neves
• Associated research grant(s): 25/12852-9 - European Society for Biomaterials - ESB 2025, AR.EXT
• Associated scholarship(s): 24/07392-6 - Development of a diabetic 3D skin model, BP.PD

Abstract

Diabetic skin problems are a serious health condition with currently poor effective cure. In this project we will develop 1) regenerative scaffolds (advanced materials) with the ability to promote skin healing of diabetic wounds and 2) a three-layered in vitro human skin modeling hypodermis, dermis and epidermis, for usage as a non-clinical in vitro template to study diabetic skin. Molecularly-defined scaffolds with defined 3D structure and composition with specific effector molecules will be tested in the diabetic skin model and results will be validated through established preclinical tests. Next to that, a diabetic skin model will be developed that promotes the reduction of animals in preclinical evaluations and advances the fields of engineering, cell biology, and disease models. The developed advanced dermal substitutes will be fully characterized and their therapeutic properties, which may be directed to multiple manifestations observed in diabetic wounds, will bring new solutions to patients with diabetes. The development of this technology has been considered a frontier development in regenerative medicine, with direct impact in healthcare, bringing great scientific and innovative advancements. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AVELINO, THAYNA M.; HARB, SAMARAH V.; ADAMOSKI, DOUGLAS; OLIVEIRA, LARISSA C. M.; HORINOUCHI, CINTIA D. S.; DE AZEVEDO, RAFAEL J.; AZOUBEL, RAFAEL A.; THOMAZ, VANESSA K.; BATISTA, FERNANDA A. H.; D'AVILA, MARCOS AKIRA; et al. Unveiling the impact of hypodermis on gene expression for advancing bioprinted full-thickness 3D skin models. COMMUNICATIONS BIOLOGY, v. 7, n. 1, p. 13-pg., 2024-11-11. (22/14725-6)