Identification of new biomarkers for Canine Prostatic Carcinoma

• Grant number: 22/14034-3
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2024
• End date: April 30, 2026
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Carlos Eduardo Fonseca Alves
• Grantee: Carlos Eduardo Fonseca Alves
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Heidge Fukumasu ; Marxa Leao Figueiredo ; Renee Laufer Amorim

Abstract

The prostate gland is a organ of subjected o aging-related diseases and both benign and malignant prostatic disorders are among the most common diseases affecting men. There are a wide variety of treatment options for the diagnosis of prostate cancer in humans, depending on the risk category the disease falls into. The dog is the only mammal, besides man, that spontaneously develops canine prostatic hyperplasia (PH), prostatic atrophy and prostatic carcinoma (PCa), associated with age, androgenic hormones, in addition to pre-neoplastic lesions, however, in contrast to PCa in humans, PCa in dogs is not androgen dependent, therefore androgen deprivation therapy is not effective, thus developing castration-resistant prostatic carcinoma (CRPC). Many treatment modalities used in usual human PCa cannot be applied in CPRC. And in relation to dogs, unfortunately, there is still no effective therapy for the treatment of these tumors, where the pharmacological treatments available are scarce, based summarily on the prescription of anti-inflammatory drugs, with a low degree of survival. Thus, there is a necessity to carry out new translational studies in human and canine PCa, aiming at the identification of predictive markers and potential common therapeutic targets, elucidating the antitumor effect of existing drugs and aiming at the development of targeted therapies. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOS ANJOS, DENNER SANTOS; CIVA, PATRICK ANTONIO SONAGLIO; WERNER, JULIANA; VICENTE, IGOR SIMOES TIAGUA; FONSECA-ALVES, CARLOS EDUARDO. Immunohistochemistry Screening of Different Tyrosine Kinase Receptors in Canine Solid Tumors-Part I: Proposal of a Receptor Panel to Predict Therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 25, n. 15, p. 13-pg., 2024-08-01. (22/14034-3)