Nano cubesome with crystalline phase and functionalized with biopolymers: Structural advances aimed at oral application

• Grant number: 24/01040-0
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2024
• End date: June 30, 2026
• Field of knowledge: Biological Sciences - Biophysics - Biophysics of Processes and Systems
• Principal Investigator: Omar Mertins
• Grantee: Omar Mertins
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Angelina Angelova ; Patrick Mathews Delgado ; Rosangela Itri
• Associated research grant(s): 25/01928-4 - Development and Characterization of pH-Responsive Smart Cubosome Nanoparticles for Oral Drug Delivery, AP.R SPRINT

Abstract

Research into bicontinuous cubic phase nanostructured materials is expanding, especially as delivery systems for applications of bioactive agents in medicine. The functionalization of nanocarrier cubosomes by conjugation with pH-responsive biopolymers offers promising possibilities for oral drug delivery, driving a new generation of therapies especially against cancer. In this project we aim to progress in the development of hybrid cubosomes functionalized with biopolymers, producing them in a solid state in the form of lyophilized powder. The studies must advance the scientific aspects related to the production and characterization of the material, as well as provide the application improvement of the bioactive carrier system. (AU)