Therapeutic, pharmacokinetic and pharmacodynamic profile of the oligopeptides derived from the snake venom B. Jararaca in the Parkinson's disease model in Zebrafish

• Grant number: 24/02247-8
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2024
• End date: June 30, 2026
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Agreement: CNPq
• Principal Investigator: Carlos Alberto da Silva
• Grantee: Carlos Alberto da Silva
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Santo André , SP, Brazil
• City of the host institution: Santo André
• Associated research grant: 23/03608-1 - Bioprospection of neuroprotective peptides from snake venoms in vitro and in vivo experimental models for the study of neurodegenerative diseases, AP.R
• Associated scholarship(s): 24/10831-1 - Therapeutic, pharmacokinetic and pharmacodynamic profile of the oligopeptides derived from the snake venom B. Jararaca in the Parkinson's disease model in Zebrafish, BP.JD

Abstract

Neuroprotection mediated by proline-rich oligopeptides (PROs), derived from Bothrops jararaca snake venom, has been reported when different neuronal cell cultures are pre-treated with PROs and then exposed to oxidative stress. The neuroprotection of PRO-10c (

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MALESKI, ADOLFO LUIS ALMEIDA; SILVA, FELIPE ASSUMPCAO DA CUNHA E; ECHEVERRY, MARCELA BERMUDEZ; ALBERTO-SILVA, CARLOS. Integrated Behavioral and Proteomic Characterization of MPP⁺-Induced Early Neurodegeneration and Parkinsonism in Zebrafish Larvae. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 26, n. 14, p. 23-pg., 2025-07-15. (23/03608-1, 24/10831-1, 24/02247-8)