Study of uncharacterized genes of Saccharomyces cerevisiae and intersections in the metabolim leading to mitochondrial gene expression regulation.

• Grant number: 24/01152-3
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2024
• End date: June 30, 2026
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: Mario Henrique de Barros
• Grantee: Mario Henrique de Barros
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: LETICIA VELOSO RIBEIRO FRANCO

Abstract

In most eukaryotes, the mitochondrial respiratory complexes, ATP synthase, and mitoribosome are genetic hybrids encoded by nuclear and mitochondrial genes. An emerging area of mitochondrial research seeks to decipher mechanisms by which these genetic, hetero-oligomeric hybrids are coordinately formed achieving optimal stoichiometry between them. In recent years, this laboratory has contributed to the identification of new factors and mechanisms that lead to the regulated and balanced expression of the components of these mitochondrial protein complexes. This project seeks to delve deeper into the characterization of these factors, in addition to as yet uncharacterized Saccharomyces cerevisiae genes that point to intersections with other spheres of mitochondrial metabolism. (AU)