Biofunctionalization of biomedical Ti-based alloys using micro-arc oxidation and the concept of high entropy oxides

• Grant number: 24/03148-3
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2024
• End date: July 31, 2026
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Diego Rafael Nespeque Correa
• Grantee: Diego Rafael Nespeque Correa
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• Associated researchers: Mariana Luna Lourenço
• Associated scholarship(s): 24/14878-2 - Synthesis of bioactive coatings based on high entropy oxides using the micro-arc oxidation of a metal matrix composite, BP.IC

Abstract

In orthopedy, total joint replacements for hip (THR) and knee (TKR) based on titanium have been the main focus of researchers in the biomedical area, once the region supports critical biomechanical loads of the human body joints, which expose the materials to constant corrosion and wear mechanisms, resulting in a decay of their lifespan. The Ti-6Al-4V alloy (ASTM F136) is the most used titanium alloy worldwide, especially in medicine. However, the ion release of potentially toxic and allergenic Al and V ions after long-term implantation has required new strategies for surface coating. Within the available surface modification techniques of metals, plasma-based techniques have been highlighted in the biomedical field, especially the micro-arc oxidation (MAO) treatment. The MAO has been established as an important tool to modify the titanium's surface, forming porous oxide coatings, strongly bound to the substrate, and enriched with specific chemical species from the electrolytic solution. One exciting possibility, never exploited before in the biomedical field, is the usage of high entropy oxide (HEO) coatings, composed of at least five distinct oxides, which have obtained emerging properties for diverse current technological applications. In this sense, the project has the goal to evaluate, for the first time, the MAO effect in the production of porous high entropy alloys (PHEOs) based on transition metallic oxides (OTMs) of Ti, Mn, Al, Mo, and Fe, and enriched with bioactive elements (Ca and P). With a specific focus on the biofunctionalization of the biomedical Ti-6Al-4V alloy, targeting potential applications as orthopedic implants. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MAURICIO, DANILO CERVANTES; GONCALVES, VINICIUS RICHIERI MANSO; TORRENTO, JHULIENE ELEN MURO; PINTAO, CARLOS ALBERTO FONZAR; GRANDINI, CARLOS ROBERTO; AFONSO, CONRADO RAMOS MOREIRA; DE ALMEIDA, GERSON SANTOS; ZAMBUZZI, WILLIAN FERNANDO; CORREA, DIEGO RAFAEL NESPEQUE. In-situ production of a biomedical metal-matrix composite based on a high entropy alloy reinforced with TiC and TiB. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T, v. 35, p. 11-pg., 2025-03-01. (23/09532-7, 22/15157-1, 24/01132-2, 24/03148-3, 24/03886-4, 21/13921-3)

CARDOSO, GIOVANA COLLOMBARO; CORREA, DIEGO RAFAEL NESPEQUE; FOSCA, MARCO; POMETUN, EVGENII V.; ANTONIAC, IULIAN V.; GRANDINI, CARLOS ROBERTO; RAU, JULIETTA V.. Current Strategies in Developing Antibacterial Surfaces for Joint Arthroplasty Implant Applications. MATERIALS, v. 18, n. 1, p. 18-pg., 2025-01-01. (24/03148-3, 21/15018-9)

COAN, KARINE STEFANY; DE SOUSA, TIAGO DOS SANTOS PEREIRA; GRANDINI, CARLOS ROBERTO; RANGEL, ELIDIANE CIPRIANO; DA CRUZ, NILSON CRISTINO; BARBARO, KATIA; FOSCA, MARCO; RAU, JULIETTA, V; TSIPAS, SOPHIA ALEXANDRA; CORREA, DIEGO RAFAEL NESPEQUE. Addressing wear-resistant, bioactive, and bio-selective coatings on the biomedical Ti-6Al-4 V alloy by performing MAO treatment in TMO-rich electrolyte. Applied Surface Science, v. 689, p. 13-pg., 2025-04-30. (21/13921-3, 24/03148-3, 18/24931-7)