Omics Sciences applied to Immunometabolism exercise and nutrition

• Grant number: 24/02320-7
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2024
• End date: January 31, 2026
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Fábio Santos de Lira
• Grantee: Fábio Santos de Lira
• Principal researcher abroad: Karsten Kruger
• Institution abroad: Justus Liebig University Giessen (JLU) , Germany
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• City of the host institution: Presidente Prudente
• Associated research grant: 22/13978-8 - Exercise-induced metabolic programming of NK cells: the mTORC1 pathway or adrenergic signalling, AP.R

Abstract

The principal aim of the project is to examine how regular physical exercise impacts immunometabolic profiles and how these changes influence the function of natural killer (NK) cells. Through comprehensive analysis of metabolic pathways, gene expression patterns, and functional assays, we aim to reveal the specific metabolic adaptations and remodelling processes in NK cells that contribute to their potent antitumour activity in individuals who have maintained a lifelong exercise training regimen. The working hypothesis was that lifelong exercise could improve the metabolism of immune cells, particularly NK cells, thereby enhancing their effector function and potentially creating a tumour-suppressive metabolic environment. (AU)