| Grant number: | 02/05880-4 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Start date: | September 01, 2003 |
| End date: | December 31, 2007 |
| Field of knowledge: | Health Sciences - Medicine - Maternal and Child Health |
| Principal Investigator: | Magda Maria Sales Carneiro-Sampaio |
| Grantee: | Magda Maria Sales Carneiro-Sampaio |
| Host Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| City of the host institution: | São Paulo |
| Principal investigators | Antonio Condino Neto ; Beatriz Tavares Costa Carvalho ; Dirceu Solé ; Maria Odete Esteves Hilário |
Abstract
The aim of this project is to improve the investigation in Primary Immunodeficiences (PID) in our country, in order to reach a level comparable to the best international centers specialized in this kind of illnesses. The project is an outcome of the gathering of clinic and basic immunologists, geneticists and molecular biologists from three different public institutions (Universidade de S. Paulo -USP, Universidade Federal de São Paulo -UNIFESP e Universidade de Campinas -UNICAMP) and from the Albert Einstein Jewish Hospital. The specific targets of this project are: (a) implementation of the capacity of PID identification, searching cases in the risk pediatric groups (patients with recurrent and severe infections, auto-immune rheumatic diseases, severe allergic manifestations); (b) elucidation of the cellular and molecular bases of some PID, giving priority to antibody synthesis deficiency with normal serum immunoglobulin, and to chronic granulomatous disease of infancy; (c) search of prognosis markers for persistent hypogamaglobulinemias in infants and young children; (d) evaluation of immunocompetence in patients with well defined genetic syndromes and high susceptibility to infections, beginning with the Rubinstein- Taybi syndrome. The primary immunodeficiences are largely deemed as privileged situations for the elucidation of the mechanisms that regulate the growth, the differentiation, the communication and the effector functions of the cells involved in the immune response, particularly the ones related to resistance to infections. Therefore, this project can contribute for the development of the immunological research in our country and, also, for a better training of clinical and pediatric immunologists, as well as of basic researchers in human immunology. The present initiative is also associated to a continuous education project (Primary Immunodeficiences Diagnosis and Management Centers for Brazil), funded by St. Jude's Hospital, at Memphis, TN, USA. This association will increase the professional expertise (of pediatricians and generalist doctors) for early case detection and appropriated clinical and therapeutic approaches. lt will provide better diagnostic and treatment conditions for these diseases in our country, improving the patients' quality of life, avoiding sequels and offering them the benefit, in the future, of genetic therapy. (AU)
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