LONGITUDINAL STUDY OF LIPIDIC AND MINERAL PROFILE IN PATIENTS ON PERITONEAL DIALYSIS

• Grant number: 23/10983-3
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2024
• End date: September 30, 2026
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Rosilene Motta Elias Coelho
• Grantee: Rosilene Motta Elias Coelho
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Daniela Ponce ; Dayana Bitencourt Dias ; Marisa Passarelli ; Rosa Maria Affonso Moysés

Abstract

Chronic Kidney Disease (CKD) prevalence has increased worldwide. Cardiovascular disease is the main cause of mortality in this population. The use of glucose in the peritoneal dialysis (PD) fluid is expected to worsen the patient's lipid profile, already altered by the CKD itself. The HDL (high-density lipoprotein) molecule can change under these conditions, not only in its quantity but also in its functionality. Furthermore, the use of calcium in the dialysate favours vascular calcification and adynamic bone disease, a complication known as CKD-mineral and bone metabolism disorder (CKD-MBD). Therefore, it is important to understand changes in lipid and mineral profiles that occurred in patients on peritoneal dialysis, both associated with cardiovascular mortality in this population. The literature is scarce for PD patients. Prospective studies may answer some important questions to help us to understand the pathophysiology of these changes so that strategies can be outlined. The aim of this study is to analyze the functionality of HDL and the propensity for vascular calcification in patients on peritoneal dialysis. Therefore, the study will be multicenter, prospective, with a randomized arm for the study of CKD-MBD. (AU)