Towards understanding the effects of bile acids on the endocrine pancreas: from health to obesity and double burden of malnutrition.

• Grant number: 24/09785-5
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2024
• End date: March 31, 2026
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Everardo Magalhães Carneiro
• Grantee: Everardo Magalhães Carneiro
• Principal researcher abroad: Ivan Quesada
• Institution abroad: Universidad Miguel Hernández , Spain
• Principal researcher abroad: Ivan Quesada
• Institution abroad: Universidad Miguel Hernández , Spain
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• City of the host institution: Campinas
• Associated researchers: Ana Paula Couto Davel
• Associated research grant: 18/26080-4 - Characterization of molecular and functional mechanisms involved in endocrine-metabolic, cardiovascular and neural dysfunctions induced by the restriction of amino acids in vitro and in vivo: possible therapeutic role of bile acid TUDCA, AP.TEM

Abstract

Malnutrition constitutes one of the greatest health challenges in our current society, and involves both situations of malnutrition and obesity, which in turn constitute a key factor in the development of type 2 diabetes (T2D). Millions of people in the world have these nutritional imbalances, with significant impacts on both health and the economy. Several epidemiological studies have reported an increasing prevalence of a state of malnutrition recognized by the WHO, known as double burden malnutrition (DBM), that entails malnutrition usually in childhood followed by the development of obesity in adults. DBM also has a notable impact on the function of the endocrine pancreas and the alterations that may lead to the development of T2D. Given that the prevalence of all these malnutrition states continues to increase and their social and medical impact will be increasing according to epidemiological predictions, it is necessary to know both the etiology and the mechanisms involved in these alterations and the associated comorbidities and how to design therapeutic strategies and preventive policies. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

DA SILVA JUNIOR, JOEL ALVES; VETTORAZZI, JEAN FRANCIESCO; SORIANO, SERGI; BRU-TARI, EVA; BORONAT-BELDA, TALIA; CASTELLANO-MUNOZ, MANUEL; BORCK, PATRICIA CRISTINE; RIBEIRO, ROSANE APARECIDA; SOARES, GABRIELA MOREIRA; LUBACZEUSKI, CAMILA; et al. Inhibition of glucagon secretion from pancreatic α-cells by the bile acid TUDCA involves a S1PR2-PI3K pathway. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 146, p. 10-pg., 2025-09-11. (24/09785-5, 13/07607-8, 17/13410-3, 21/02734-8, 18/26080-4)