Perinatal asphyxia and use of antioxidant agents as neuroprotectors: relevance to Alzheimer's disease

• Grant number: 23/14779-1
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2024
• End date: September 30, 2026
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Principal Investigator: Silvia Honda Takada
• Grantee: Silvia Honda Takada
• Host Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Santo André , SP, Brazil

Abstract

Perinatal asphyxia is considered a serious public health concern worldwide, as it causes permanent sequelae, such as motor, cognitive and/or sensory deficits. Furthermore, there are reports that perinatal asphyxia may predispose individuals to autism spectrum disorder (ASD), schizophrenia, attention deficit hyperactivity disorder and, according to more recent studies, there are reports that neonatal oxygen deprivation can lead to emergence or even worsening cognitive conditions of neurodegenerative diseases, such as Alzheimer's disease. The hypotheses to correlate perinatal asphyxia with the occurrence of these pathologies in the long term are based on the DOHaD (Developmental Origins of Health and Disease) concept, in which environmental, maternal, growth and development factors that affect early life have effects on vulnerability to long-term illnesses. From a cellular and molecular point of view, oxygen deprivation initially promotes energy failure, triggering neurotoxic cascades, with important oxidative stress, neuroinflammation and cell death, events that can persist throughout life, leading to disruption in proliferation, myelination and synaptogenesis and changes in brain plasticity. Thus, the objective of the present project is to investigate the effects of the use of antioxidants, such as melatonin, on the long-term events of perinatal asphyxia, including greater vulnerability to neurodegenerative diseases, such as Alzheimer's disease, using an animal model of premature aging. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ARRUDA, BRUNA PETRUCELLI; MARTINS, PAMELA PINHEIRO; KIHARA, ALEXANDRE HIROAKI; TAKADA, SILVIA HONDA. Perinatal asphyxia and Alzheimer's disease: is there a correlation?. FRONTIERS IN PEDIATRICS, v. 13, p. 7-pg., 2025-03-18. (23/14779-1)

LEE, VITOR YONAMINE; NILS, ALINE VILAR MACHADO; ARRUDA, BRUNA PETRUCELLI; XAVIER, GILBERTO FERNANDO; NOGUEIRA, MARIA INES; MOTTA-TEIXEIRA, LIVIA CLEMENTE; TAKADA, SILVIA HONDA. Spontaneous running wheel exercise during pregnancy prevents later neonatal-anoxia-induced somatic and neurodevelopmental alterations. IBRO NEUROSCIENCE REPORTS, v. 17, p. 17-pg., 2024-09-09. (11/03960-0, 19/17239-2, 11/19747-3, 10/01488-9, 23/14779-1, 20/16268-6)