Silver nanoparticles obtained from natural products for the treatment of infections caused by multiresistant bacteria

• Grant number: 24/19277-7
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2025
• End date: January 31, 2027
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: João Henrique Ghilardi Lago
• Grantee: João Henrique Ghilardi Lago
• Principal researcher abroad: Myron Christodoulides
• Institution abroad: University of Southampton , England
• Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Santo André , SP, Brazil
• City of the host institution: Santo André
• Associated researchers: André Gustavo Tempone Cardoso ; Patricia Sartorelli
• Associated research grant: 23/12447-1 - Searching for specialized metabolites from Brazilian floristic biodiversity as drug candidates for neglected tropical diseases, AP.BTA.R

Abstract

The use of nanotechnology has been widely used in the last decade, emerging as a technological revolution that has presented a low-cost alternative with more effective action due to its nanometric size. The combination of nanotechnology and natural products from medicinal plants or fungi may be a new approach to seek to improve the treatment of some diseases. Additionally, considering the significant increase in multidrug-resistant bacteria, the World Health Organization published a list of bacteria that represent the greatest threat to human health, aiming to promote research into new antibiotics. In this context, natural products, a source of inspiration for obtaining new antibiotics, can be used in natura or can be combined with silver nanoparticles to enhance their antimicrobial potential. Thus, the project aims to evaluate natural products extracted from plants and fungi and their combinations with silver nanoparticles concerning their bactericidal potential, including against some multidrug-resistant strains, which may be a promising alternative to current drugs. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

ABIUZI, MARIANA B.; DE ANDRADE, BEATRIZ A.; RAMOS, FERNANDA F.; TOTINI, CARLOS H.; CHRISTODOULIDES, MYRON; KANT, RAVI; LAGO, JOAO HENRIQUE G.; TEMPONE, ANDRE G.. The Marine Microbial Alkaloid (R)-Salsolinol is Effective Against Trypanosoma cruzi. CHEMISTRY & BIODIVERSITY, v. N/A, p. 9-pg., 2025-03-15. (23/12447-1, 24/19277-7, 23/07414-7, 21/04464-8)