Lipid nanoparticles: development of processes for obtaining and therapeutically applying multifunctional systems.

• Grant number: 25/13788-2
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2025
• End date: September 30, 2026
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Maria Vitória Lopes Badra Bentley
• Grantee: Maria Vitória Lopes Badra Bentley
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto
• Associated research grant: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach, AP.TEM
• Associated scholarship(s): 25/21966-8 - Development of method for obtaining solid lipid nanoparticles: Comparative study of top-down and self-assembled processes, BP.IC; 25/21963-9 - Multifunctional Nanostructured Lipid Carrier Containing 5-Fluorouracil and Methotrexate for Topical Skin Cancer Therapy, BP.IC

Abstract

The two scientific initiation proposals (Work Plans) presented aim to provide students with a more solid learning experience and also to acquire knowledge in the area of ¿¿pharmaceutical nanotechnology, focusing on the synthesis of nanoparticles and co-encapsulation of drugs in lipid nanoparticles. Both proposals aim to contribute to solutions for technological and therapeutic gaps through nanotechnology.In Plan 1, solid lipid nanoparticles (SLNs), which are promising colloidal systems for controlled drug delivery, will be obtained through different methods involving top-down processes (sonication and high-pressure homogenization) and self-assembled processes (microfluidics), aiming to obtain more stable SLNs with adequate colloidal properties. The procedures will be standardized and compared with each other. The comparison between these approaches will allow evaluating the impact of the production method on the physicochemical stability of the SLNs. The Plan will provide students with a more solid learning experience and also acquire knowledge of the microfluidics process, a current and modern method of nanoparticle synthesis.Plan 2 proposes the development of a multifunctional nanostructured lipid carrier (NLC) for the topical treatment of skin cancer, combining two chemotherapeutic drugs with distinct mechanisms of action, inserted into the nanoparticle using different strategies. The proposal stands out for its innovative approach and potential impact on the development of more effective, safe, and targeted therapies for one of the most prevalent forms of cancer. of cancer in Brazil. (AU)