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Neuro-humoral regulation of the cadiovascular system in physiological and physiopathological conditions

Abstract

The experiments proposed in the present project, ranging from in vivo animal recordings of physiologic parameters and morphometric studies to cell culture and biochemical and molecular biology determinations, are designed to explore in depth some aspects of the neurohumoral regulation of the cardiovascular system and represent the natural extension of our previous work in the topic. The main biologic problems under study include: a) the mechanisms underlying the alterations in the reflex regulation of heart rate and arterial blood pressure in models of diabetes and hypertension; b) endothelial mechanisms involved in the formation and degradation of vasoactive peptides under physiologic and pathophysiologic conditions and c) mechanisms of NO production and action in physiologic and pathophysiologic conditions. Some of the experimental approaches involve methodologies such as electroneuronography of baroreceptorafferents and spectral analysis of heart rate and arterial blood pressure, which will be performed in rats with streptozotocin-induced diabetes or with genetic hypertension and in normal mice, are routinely employed in our laboratories. Similarly, the investigation of the roles of peptidases in the formation and metabolism of vasoactive peptides, especially angiotensin II, as well as the exploration of the contribution of nitric oxide to the pregnancy-associated hyporeactivity to vasoconstrictors will employ the perfusion of isolated vascular beds and myography of isolated arterial segments together with biochemical determinations already in use in our laboratories. Other experimental approaches, such as endothelial cell culture and myographic studies of pressurized resistance vessels, which will allow us to explore the regulation of the expression and release of peptidases, especially elastase-2, as well as the regulation of nitric oxide production will require the implementation of new techniques. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEREIRA, MARILIA G. A. G.; SOUZA, LAURA L.; BECARI, CHRISTIANE; DUARTE, DIEGO A.; CAMACHO, FABIO R. B.; OLIVEIRA, JOSE ANTONIO C.; GOMES, MARCELO D.; OLIVEIRA, EDUARDO B.; SALGADO, MARIA CRISTINA O.; GARCIA-CAIRASCO, NORBERTO; COSTA-NETO, CLAUDIO M. Angiotensin II-Independent Angiotensin-(1-7) Formation in Rat Hippocampus Involvement of Thimet Oligopeptidase. Hypertension, v. 62, n. 5, p. 879-885, NOV 2013. Web of Science Citations: 14.
PEREIRA, MARILIA G. A. G.; BECARI, CHRISTIANE; OLIVEIRA, JOSE A. C.; SALGADO, MARIA CRISTINA O.; GARCIA-CAIRASCO, NORBERTO; COSTA-NETO, CLAUDIO M. Inhibition of the renin-angiotensin system prevents seizures in a rat model of epilepsy. Clinical Science, v. 119, n. 11-12, p. 477-482, DEC 2010. Web of Science Citations: 38.
M.T. DURAND; R. FAZAN JR.; M.C.O. SALGADO; H.C. SALGADO. Acute and chronic electrical activation of baroreceptor afferents in awake and anesthetized subjects. Brazilian Journal of Medical and Biological Research, v. 42, n. 1, p. 53-60, Jan. 2009.
VALERIA PAULA SASSOLI FAZAN; ORNAR ANDRADE RODRIGUES FILHO; FERNANDO MATAMATA. Communication Between the Mylohyoid and Lingual Nerves: Clinical Implications. INTERNATIONAL JOURNAL OF MORPHOLOGY, v. 25, n. 3, p. 561-564, Set. 2007.
ROGÉRIO ALVES RIBEIRO; JOÃO ALBERTO DE SOUZA RIBEIRO; OMAR ANDRADE RODRIGUES FILHO; ABADIO GONÇALVES CAETANO; VALÉRIA PAULA SASSOLI FAZAN. Common Carotid Artery Bifurcation Levels Related to Clinical Relevant Anatomical Landmarks. INTERNATIONAL JOURNAL OF MORPHOLOGY, v. 24, n. 3, p. 413-416, Set. 2006.
VALÉRIA PAULA SASSOLI FAZAN; ANDRÉ DE SOUZA AMADEU; ADILSON L. CALEFFI; OMAR ANDRADE RODRIGUES FILHO. Brachial plexus variations in its formation and main branches. Acta Cirurgica Brasileira, v. 18, p. 14-18, 2003.
VALÉRIA PAULA SASSOLI FAZAN; ROGÉRIO ALVES RIBEIRO; JOÃO ALBERTO S. RIBEIRO; OMAR ANDRADE RODRIGUES FILHO. Right retroesophageal subclavian artery. Acta Cirurgica Brasileira, v. 18, p. 54-56, 2003.

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