Post-traumatic stress disorder: epidemiology, physiopathology and treatment

• Grant number: 04/15039-0
• Support type: Research Projects - Thematic Grants
• Duration: February 01, 2006 - January 31, 2010
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal researcher: Jair de Jesus Mari
• Grantee: Jair de Jesus Mari
• Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Pesquisadores principais: Rodrigo Affonseca Bressan ; Sérgio Baxter Andreoli
• Associated scholarship(s): 09/01358-0 - Neuropsychological study of factors related to the resilience and vulnerability to post-traumatic stress disorder, BP.PD

Abstract

The epidemiological study will select at random and deliberately, a sample of 3,000 inhabitants of the city of São Paulo, which is representative of the various demographic areas, embracing the whole complexity of the socioeconomic network of the city This sample will be representative of the population in its various social backgrounds, taking into account different socio-demographic risks factors for victimization and development of PTSD. The epidemiological study will make it possible to identify the individuals who were victims of violence and did not develop PTSD (CIDI). On the basis of this sample, 120 individuals will be recruited, paired by sex, age and socio-demographic distribution with the case study group. The case studies and control group will be compared in a neuro-image, genetic, neuro-endocrinological, neuropsychological and dopamiergic receptors and carriers study for the understanding of the risk factors and protection in PTSD. The themed study will also evaluate the treatments for PTSD, including a clinical trial comparing Topiramate and cognitive behavioral therapy. There will be a link between the clinical epidemiological studies and the development of animal models to mimic PTSD. (AU)

Scientific publications

(35)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FILLENBAUM, GERDA G.; BLAY, SERGIO L.; MELLO, MARCELO F.; QUINTANA, I, MARIA; MARI, JAIR J.; BRESSAN, RODRIGO A.; ANDREOLI, SERGIO B. Use of mental health services by community-resident adults with DSM-IV anxiety and mood disorders in a violence-prone area: Sao Paulo, Brazil. Journal of Affective Disorders, v. 250, p. 145-152, MAY 1 2019. Web of Science Citations: 0.

DA SILVA, HERIKA C.; DA ROSA, MAISA M. FURTADO; BERGER, WILLIAM; LUZ, MARIANA P.; MENDLOWICZ, MAURO; COUTINHO, EVANDRO S. F.; PORTELLA, CARLA M.; MARQUES, PAMELA I. S.; MOGRABI, DANIEL C.; FIGUEIRA, IVAN; VENTURA, PAULA. PTSD in mental health outpatient settings: highly prevalent and under-recognized. Revista Brasileira de Psiquiatria, v. 41, n. 3, p. 213-217, MAY-JUN 2019. Web of Science Citations: 1.

BLAY, SERGIO L.; FILLENBAUM, GERDA G.; MELLO, MARCELO F.; QUINTANA, MARIA I.; MARI, JAIR J.; BRESSAN, RODRIGO A.; ANDREOLI, SERGIO B. 12-month prevalence and concomitants of DSM-IV depression and anxiety disorders in two violence-prone cities in Brazil. Journal of Affective Disorders, v. 232, p. 204-211, MAY 2018. Web of Science Citations: 1.

PTSD in mental health outpatient settings: highly prevalent and under-recognized. Revista Brasileira de Psiquiatria, n. ahead, p. -, 2018.

BLAY, SERGIO L.; LAKS, JERSON; MARINHO, VALESKA; FIGUEIRA, IVAN; MAIA, DEBORAH; COUTINHO, EVANDRO S. F.; QUINTANA, INES M.; MELLO, MARCELO F.; BRESSAN, RODRIGO A.; MARI, JAIR J.; ANDREOLI, SERGIO B. Prevalence and Correlates of Elder Abuse in Sao Paulo and Rio de Janeiro. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, v. 65, n. 12, p. 2634-2638, DEC 2017. Web of Science Citations: 5.

KALAF, JULIANA; FREIRE COUTINHO, EVANDRO SILVA; PEREIRA VILETE, LILIANE MARIA; LUZ, MARIANA PIRES; BERGER, WILLIAM; MENDLOWICZ, MAURO; VOLCHAN, ELIANE; ANDREOLI, SERGIO BAXTER; QUINTANA, MARIA INES; MARI, JAIR DE JESUS; FIGUEIRA, IVAN. Sexual trauma is more strongly associated with tonic immobility than other types of trauma - A population based study. Journal of Affective Disorders, v. 215, p. 71-76, JUN 2017. Web of Science Citations: 3.

BALDACARA, LEONARDO; ARAUJO, CLIA; ASSUNCAO, IDAIANE; DA SILVA, IVALDO; JACKOWSKI, ANDREA PAROLIN. Reduction of prefrontal thickness in military police officers with post-traumatic stress disorder. ARCHIVES OF CLINICAL PSYCHIATRY, v. 44, n. 4, p. 94-98, 2017. Web of Science Citations: 0.

JAEN-VARAS, DENISSE; MARI, JAIR DE JESUS; COUTINHO, EVANDRO DA SILVA; ANDREOLI, SERGIO BAXTER; QUINTANA, MARIA INES; DE MELLO, MARCELO FEIJO; BRESSAN, RODRIGO AFFONSECA; RIBEIRO, WAGNER SILVA. A cross-sectional study to compare levels of psychiatric morbidity between young people and adults exposed to violence in a large urban center. BMC Psychiatry, v. 16, JUN 7 2016. Web of Science Citations: 2.

LUZ, MARIANA PIRES; COUTINHO, EVANDRO S. F.; BERGER, WILLIAM; MENDLOWICZ, MAURO V.; VILETE, LILIANE M. P.; MELLO, MARCELO F.; QUINTANA, MARIA INES; BRESSAN, RODRIGO A.; ANDREOLI, SERGIO B.; MARI, JAIR J.; FIGUEIRA, IVAN. Conditional risk for posttraumatic stress disorder in an epidemiological study of a Brazilian urban population. JOURNAL OF PSYCHIATRIC RESEARCH, v. 72, p. 51-57, JAN 2016. Web of Science Citations: 8.

PUPO, MARIANA CADROBBI; SERAFIM, PAULA MARIA; DE MELLO, MARCELO FEIJO. Health-related quality of life in posttraumatic stress disorder: 4 years follow-up study of individuals exposed to urban violence. PSYCHIATRY RESEARCH, v. 228, n. 3, p. 741-745, AUG 30 2015. Web of Science Citations: 1.

QUINTANA, MARIA INES; ANDREOLI, SERGIO BAXTER; PELUFFO, MARCELA POCTICH; RIBEIRO, WAGNER SILVA; FEIJO, MARCELO M.; BRESSAN, RODRIGO AFFONSECA; COUTINHO, EVANDRO S. F.; MARI, JAIR DE JESUS. Psychotropic Drug Use in Sao Paulo, Brazil - An Epidemiological Survey. PLoS One, v. 10, n. 8 AUG 7 2015. Web of Science Citations: 6.

KALAF, JULIANA; VILETE, LILIANE MARIA PEREIRA; VOLCHAN, ELIANE; FISZMAN, ADRIANA; FREIRE COUTINHO, EVANDRO SILVA; ANDREOLI, SERGIO BAXTER; QUINTANA, MARIA INES; MARI, JAIR DE JESUS; FIGUEIRA, IVAN. Peritraumatic tonic immobility in a large representative sample of the general population: association with posttraumatic stress disorder and female gender. COMPREHENSIVE PSYCHIATRY, v. 60, p. 68-72, JUL 2015. Web of Science Citations: 9.

MOREIRA, F. G.; QUINTANA, M. I.; RIBEIRO, W.; BRESSAN, R. A.; MELLO, M. F.; MARI, J. J.; ANDREOLI, S. B. Revictimization of Violence Suffered by Those Diagnosed with Alcohol Dependence in the General Population. BIOMED RESEARCH INTERNATIONAL, 2015. Web of Science Citations: 0.

BALDACARA, LEONARDO; ZUGMAN, ANDRE; ARAUJO, CELIA; COGO-MOREIRA, HUGO; TAVARES LACERDA, ACIOLY LUIZ; SCHOEDL, ALINE; PUPO, MARIANA; MELLO, MARCELO FEIJO; ANDREOLI, SERGIO B.; MARI, JAIR DE JESUS; BRESSAN, RODRIGO AFFONSECA; JACKOWSKI, ANDREA PAROLIN. Reduction of anterior cingulate in adults with urban violence- related PTSD. Journal of Affective Disorders, v. 168, p. 13-20, OCT 15 2014. Web of Science Citations: 11.

VILETE, LILIANE; FIGUEIRA, IVAN; ANDREOLI, SERGIO BAXTER; RIBEIRO, WAGNER; QUINTANA, MARIA INES; MARI, JAIR DE JESUS; FREIRE COUTINHO, EVANDRO SILVA. Resilience to trauma in the two largest cities of Brazil: a cross-sectional study. BMC Psychiatry, v. 14, SEP 16 2014. Web of Science Citations: 4.

SCHOEDL, ALINE F.; COSTA, MARIANA P.; FOSSALUZA, VICTOR; MARI, JAIR J.; MELLO, MARCELO F. Specific traumatic events during childhood as risk factors for posttraumatic stress disorder development in adults. JOURNAL OF HEALTH PSYCHOLOGY, v. 19, n. 7, p. 847-857, JUL 2014. Web of Science Citations: 5.

REICHENHEIM, MICHAEL; SOUZA, WANDERSON; FREIRE COUTINHO, EVANDRO SILVA; FIGUEIRA, IVAN; QUINTANA, MARIA INES; DE MELLO, MARCELO FEIJO; BRESSAN, RODRIGO AFFONSECA; MARI, JAIR DE JESUS; ANDREOLI, SERGIO BAXTER. Structural Validity of the Tonic Immobility Scale in a Population Exposed to Trauma: Evidence from Two Large Brazilian Samples. PLoS One, v. 9, n. 4 APR 18 2014. Web of Science Citations: 3.

LIMA, ADRIANO R.; MELLO, MARCELO F.; ANDREOLI, SERGIO B.; FOSSALUZA, VICTOR; DE ARAUJO, CELIA M.; JACKOWSKI, ANDREA P.; BRESSAN, RODRIGO A.; MARI, JAIR J. The Impact of Healthy Parenting As a Protective Factor for Posttraumatic Stress Disorder in Adulthood: A Case-Control Study. PLoS One, v. 9, n. 1 JAN 29 2014. Web of Science Citations: 8.

FLAKS, MARIANA K.; MALTA, STELLA M.; ALMEIDA, PRISCILA P.; BUENO, ORLANDO F. A.; PUPO, MARIANA C.; ANDREOLI, SERGIO B.; MELLO, MARCELO F.; LACERDA, ACIOLY L. T.; MARI, JAIR J.; BRESSAN, RODRIGO A. Attentional and executive functions are differentially affected by post-traumatic stress disorder and trauma. JOURNAL OF PSYCHIATRIC RESEARCH, v. 48, n. 1, p. 32-39, JAN 2014. Web of Science Citations: 19.

RIBEIRO, WAGNER SILVA; MARI, JAIR DE JESUS; QUINTANA, MARIA INES; DEWEY, MICHAEL E.; EVANS-LACKO, SARA; PEREIRA VILETE, LILIANE MARIA; FIGUEIRA, IVAN; BRESSAN, RODRIGO AFFONSECA; DE MELLO, MARCELO FEIJO; PRINCE, MARTIN; FERRI, CLEUSA P.; FREIRE COUTINHO, EVANDRO SILVA; ANDREOLI, SERGIO BAXTER. The Impact of Epidemic Violence on the Prevalence of Psychiatric Disorders in Sao Paulo and Rio de Janeiro, Brazil. PLoS One, v. 8, n. 5 MAY 8 2013. Web of Science Citations: 48.

HOEXTER, MARCELO Q.; FADEL, GUSTAVO; FELICIO, ANDRE C.; CALZAVARA, MARIANA B.; BATISTA, ILZA R.; REIS, MARILIA A.; SHIH, MING C.; PITMAN, ROGER K.; ANDREOLI, SERGIO B.; MELLO, MARCELO F.; MARI, JAIR J.; BRESSAN, RODRIGO A. Higher striatal dopamine transporter density in PTSD: an in vivo SPECT study with [Tc-99m]TRODAT-1. Psychopharmacology, v. 224, n. 2, p. 337-345, NOV 2012. Web of Science Citations: 25.

QUINTANA, MARIA INES; MARI, JAIR DE JESUS; RIBEIRO, WAGNER SILVA; JORGE, MIGUEL ROBERTO; ANDREOLI, SERGIO BAXTER. Accuracy of the Composite International Diagnostic Interview (CIDI 2.1) for diagnosis of post-traumatic stress disorder according to DSM-IV criteria. Cadernos de Saúde Pública, v. 28, n. 7, p. 1312-1318, JUL 2012. Web of Science Citations: 10.

BARBOSA NETO, JAIR B.; TIBA, PAULA A.; FATURI, CLAUDIA B.; DE CASTRO-NETO, EDUARDO F.; NAFFAH-MAZACORATTI, MARIA DA GRACA; MARIA, JAIR DE JESUS; DE MELLO, MARCELO F.; SUCHECKI, DEBORAH. Stress during development alters anxiety-like behavior and hippocampal neurotransmission in male and female rats. Neuropharmacology, v. 62, n. 1, SI, p. 518-526, JAN 2012. Web of Science Citations: 32.

BALDACARA, LEONARDO; JACKOWSKI, ANDREA P.; SCHOEDL, ALINE; PUPO, MARIANA; ANDREOLI, SERGIO B.; MELLO, MARCELO F.; LACERDA, ACIOLY L. T.; MARI, JAIR J.; BRESSAN, RODRIGO A. Reduced cerebellar left hemisphere and vermal volume in adults with PTSD from a community sample. JOURNAL OF PSYCHIATRIC RESEARCH, v. 45, n. 12, p. 1627-1633, DEC 2011. Web of Science Citations: 34.

MARQUES VALENTE, NINA LEAO; VALLADA, HOMERO; CORDEIRO, QUIRINO; MIGUITA, KAREN; BRESSAN, RODRIGO AFFONSECA; ANDREOLI, SERGIO BAXTER; MARI, JAIR JESUS; MELLO, MARCELO FEIJO. Candidate-Gene Approach in Posttraumatic Stress Disorder After Urban Violence: Association Analysis of the Genes Encoding Serotonin Transporter, Dopamine Transporter, and BDNF. JOURNAL OF MOLECULAR NEUROSCIENCE, v. 44, n. 1, p. 59-67, MAY 2011. Web of Science Citations: 39.

MARQUES VALENTE, NINA LEAO; VALLADA, HOMERO; CORDEIRO, QUIRINO; BRESSAN, RODRIGO AFFONSECA; ANDREOLI, SERGIO BAXTER; MARI, JAIR JESUS; MELLO, MARCELO FEIJO. Catechol-O-methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD After Urban Violence. JOURNAL OF MOLECULAR NEUROSCIENCE, v. 43, n. 3, p. 516-523, MAR 2011. Web of Science Citations: 34.

PUPO, MARIANA CADROBBI; JORGE, MIGUEL ROBERTO; SCHOEDL, ALINE FERRI; BRESSAN, RODRIGO AFFONSECA; ANDREOLI, SERGIO BAXTER; MELLO, MARCELO FEIJO; MARI, JAIR DE JESUS. The accuracy of the Clinician-Administered PTSD Scale (CAPS) to identify PTSD cases in victims of urban violence. PSYCHIATRY RESEARCH, v. 185, n. 1-2, p. 157-160, JAN 30 2011. Web of Science Citations: 20.

YEH, MARY S. L.; MARI, JAIR JESUS; PUPO COSTA, MARIANA CADDROBI; ANDREOLI, SERGIO BAXTER; BRESSAN, RODRIGO AFFONSECA; MELLO, MARCELO FEIJO. A Double-Blind Randomized Controlled Trial To Study the Efficacy of Topiramate in a Civilian Sample of PTSD. CNS Neuroscience & Therapeutics, v. 17, n. 5, p. 305-310, 2011. Web of Science Citations: 21.

PASSARELA, CRISTIANE DE MEDEIROS; MENDES, DEISE DANIELA; MARI, JAIR DE JESUS. A systematic review to study the efficacy of cognitive behavioral therapy for sexually abused children and adolescents with posttraumatic stress disorder. ARCHIVES OF CLINICAL PSYCHIATRY, v. 37, n. 2, p. 69-73, 2010. Web of Science Citations: 9.

ANDREOLI, SERGIO BAXTER; RIBEIRO, WAGNER SILVA; QUINTANA, MARIA INES; GUINDALINI, CAMILA; BREEN, GEROME; BLAY, SERGIO LUIS; COUTINHO, EVANDRO S. F.; HARPHAM, TRUDY; JORGE, MIGUEL ROBERTO; LARA, DIOGO RIZZATO; MORIYAMA, TAIS S.; QUARANTINI, LUCAS C.; GADELHA, ARY; PEREIRA VILETE, LILIANE MARIA; YEH, MARY S. L.; PRINCE, MARTIN; FIGUEIRA, IVAN; BRESSAN, RODRIGO A.; MELLO, MARCELO F.; DEWEY, MICHAEL E.; FERRI, CLEUSA P.; MARI, JAIR DE JESUS. Violence and post-traumatic stress disorder in Sao Paulo and Rio de Janeiro, Brazil: the protocol for an epidemiological and genetic survey. BMC Psychiatry, v. 9, JUN 7 2009. Web of Science Citations: 26.

BRESSAN, RODRIGO A.; QUARANTINI, LUCAS C.; ANDREOLI, SERGIO B.; ARAUJO, CELIA; BREEN, GEROME; GUINDALINI, CAMILA; HOEXTER, MARCELO; JACKOWSKI, ANDREA P.; JORGE, MIGUEL R.; LACERDA, ACIOLY L. T.; LARA, DIOGO R.; MALTA, STELLA; MORIYAMA, TAIS S.; QUINTANA, MARIA I.; RIBEIRO, WAGNER S.; RUIZ, JULIANA; SCHOEDL, ALINE F.; SHIH, MING C.; FIGUEIRA, IVAN; KOENEN, KARESTAN C.; MELLO, MARCELO F.; MARI, JAIR J. The posttraumatic stress disorder project in Brazil: neuropsychological, structural and molecular neuroimaging studies in victims of urban violence. BMC Psychiatry, v. 9, JUN 1 2009. Web of Science Citations: 16.

JACKOWSKI, ANDREA PAROLIN; DE ARAUJO, CELIA MARIA; TAVARES DE LACERDA, ACIOLY LUIZ; MARI, JAIR DE JESUS; KAUFMAN, JOAN. Neurostructural imaging findings in children with post-traumatic stress disorder: Brief review. PSYCHIATRY AND CLINICAL NEUROSCIENCES, v. 63, n. 1, p. 1-8, Feb. 2009. Web of Science Citations: 36.

BRAGA, LUCIANA L.; FIKS, JOSE P.; MARI, JAIR J.; MELLO, MARCELO F. The importance of the concepts of disaster, catastrophe, violence, trauma and barbarism in defining posttraumatic stress disorder in clinical practice. BMC Psychiatry, v. 8, p. 0-0, Aug. 2008. Web of Science Citations: 8.

NINA LEÃO MARQUES VALENTE; JOSE PAULO FIKS; HOMERO VALLADA; MARCELO FEIJÓ DE MELLO. Evolucionismo e genética do transtorno de estresse pós-traumático. Revista de Psiquiatria do Rio Grande do Sul, v. 30, n. 1, p. -, 2008.

MENDES, DEISE D.; MELLO, MARCELO FEIJO; VENTURA, PAULA; PASSARELA, CRISTIANE DE MEDEIROS; MARI, JAIR DE JESUS. A SYSTEMATIC REVIEW ON THE EFFECTIVENESS OF COGNITIVE BEHAVIORAL THERAPY FOR POSTTRAUMATIC STRESS DISORDER. The International Journal of Psychiatry in Medicine, v. 38, n. 3, p. 241-259, 2008. Web of Science Citations: 51.