Post-traumatic stress disorder: epidemiology, physiopathology and treatment

• Grant number: 04/15039-0
• Support Opportunities: Research Projects - Thematic Grants
• Duration: February 01, 2006 - January 31, 2010
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Jair de Jesus Mari
• Grantee: Jair de Jesus Mari
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Pesquisadores principais: Rodrigo Affonseca Bressan ; Sérgio Baxter Andreoli
• Associated scholarship(s): 09/01358-0 - Neuropsychological study of factors related to the resilience and vulnerability to post-traumatic stress disorder, BP.PD

Abstract

The epidemiological study will select at random and deliberately, a sample of 3,000 inhabitants of the city of São Paulo, which is representative of the various demographic areas, embracing the whole complexity of the socioeconomic network of the city This sample will be representative of the population in its various social backgrounds, taking into account different socio-demographic risks factors for victimization and development of PTSD. The epidemiological study will make it possible to identify the individuals who were victims of violence and did not develop PTSD (CIDI). On the basis of this sample, 120 individuals will be recruited, paired by sex, age and socio-demographic distribution with the case study group. The case studies and control group will be compared in a neuro-image, genetic, neuro-endocrinological, neuropsychological and dopamiergic receptors and carriers study for the understanding of the risk factors and protection in PTSD. The themed study will also evaluate the treatments for PTSD, including a clinical trial comparing Topiramate and cognitive behavioral therapy. There will be a link between the clinical epidemiological studies and the development of animal models to mimic PTSD. (AU)

Scientific publications

(34)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PUPO, MARIANA CADROBBI; SERAFIM, PAULA MARIA; DE MELLO, MARCELO FEIJO. Health-related quality of life in posttraumatic stress disorder: 4 years follow-up study of individuals exposed to urban violence. PSYCHIATRY RESEARCH, v. 228, n. 3, p. 741-745, AUG 30 2015. (04/15039-0, 10/07432-5)

FILLENBAUM, GERDA G.; BLAY, SERGIO L.; MELLO, MARCELO F.; QUINTANA, I, MARIA; MARI, JAIR J.; BRESSAN, RODRIGO A.; ANDREOLI, SERGIO B.. Use of mental health services by community-resident adults with DSM-IV anxiety and mood disorders in a violence-prone area: Sao Paulo, Brazil. Journal of Affective Disorders, v. 250, p. 145-152, MAY 1 2019. (16/02246-5, 04/15039-0)

BALDACARA, LEONARDO; ARAUJO, CLIA; ASSUNCAO, IDAIANE; DA SILVA, IVALDO; JACKOWSKI, ANDREA PAROLIN. Reduction of prefrontal thickness in military police officers with post-traumatic stress disorder. ARCHIVES OF CLINICAL PSYCHIATRY, v. 44, n. 4, p. 94-98, 2017. (04/15039-0)

BLAY, SERGIO L.; FILLENBAUM, GERDA G.; MELLO, MARCELO F.; QUINTANA, MARIA I.; MARI, JAIR J.; BRESSAN, RODRIGO A.; ANDREOLI, SERGIO B.. 12-month prevalence and concomitants of DSM-IV depression and anxiety disorders in two violence-prone cities in Brazil. Journal of Affective Disorders, v. 232, p. 204-211, MAY 2018. (16/02246-5, 04/15039-0)

BLAY, SERGIO L.; LAKS, JERSON; MARINHO, VALESKA; FIGUEIRA, IVAN; MAIA, DEBORAH; COUTINHO, EVANDRO S. F.; QUINTANA, INES M.; MELLO, MARCELO F.; BRESSAN, RODRIGO A.; MARI, JAIR J.; et al. Prevalence and Correlates of Elder Abuse in Sao Paulo and Rio de Janeiro. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, v. 65, n. 12, p. 2634-2638, DEC 2017. (16/02246-5, 04/15039-0)

BARBOSA NETO, JAIR B.; TIBA, PAULA A.; FATURI, CLAUDIA B.; DE CASTRO-NETO, EDUARDO F.; NAFFAH-MAZACORATTI, MARIA DA GRACA; MARIA, JAIR DE JESUS; DE MELLO, MARCELO F.; SUCHECKI, DEBORAH. Stress during development alters anxiety-like behavior and hippocampal neurotransmission in male and female rats. Neuropharmacology, v. 62, n. 1, SI, p. 518-526, JAN 2012. (06/06415-4, 04/15039-0)

BRAGA, LUCIANA L.; FIKS, JOSE P.; MARI, JAIR J.; MELLO, MARCELO F.. The importance of the concepts of disaster, catastrophe, violence, trauma and barbarism in defining posttraumatic stress disorder in clinical practice. BMC Psychiatry, v. 8, p. 0-0, Aug. 2008. (04/15039-0)

YEH, MARY S. L.; MARI, JAIR JESUS; PUPO COSTA, MARIANA CADDROBI; ANDREOLI, SERGIO BAXTER; BRESSAN, RODRIGO AFFONSECA; MELLO, MARCELO FEIJO. A Double-Blind Randomized Controlled Trial To Study the Efficacy of Topiramate in a Civilian Sample of PTSD. CNS Neuroscience & Therapeutics, v. 17, n. 5, p. 305-310, 2011. (04/15039-0)

LUZ, MARIANA PIRES; COUTINHO, EVANDRO S. F.; BERGER, WILLIAM; MENDLOWICZ, MAURO V.; VILETE, LILIANE M. P.; MELLO, MARCELO F.; QUINTANA, MARIA INES; BRESSAN, RODRIGO A.; ANDREOLI, SERGIO B.; MARI, JAIR J.; et al. Conditional risk for posttraumatic stress disorder in an epidemiological study of a Brazilian urban population. JOURNAL OF PSYCHIATRIC RESEARCH, v. 72, p. 51-57, JAN 2016. (04/15039-0)

KALAF, JULIANA; FREIRE COUTINHO, EVANDRO SILVA; PEREIRA VILETE, LILIANE MARIA; LUZ, MARIANA PIRES; BERGER, WILLIAM; MENDLOWICZ, MAURO; VOLCHAN, ELIANE; ANDREOLI, SERGIO BAXTER; QUINTANA, MARIA INES; MARI, JAIR DE JESUS; et al. Sexual trauma is more strongly associated with tonic immobility than other types of trauma - A population based study. Journal of Affective Disorders, v. 215, p. 71-76, JUN 2017. (04/15039-0)

LIMA, ADRIANO R.; MELLO, MARCELO F.; ANDREOLI, SERGIO B.; FOSSALUZA, VICTOR; DE ARAUJO, CELIA M.; JACKOWSKI, ANDREA P.; BRESSAN, RODRIGO A.; MARI, JAIR J.. The Impact of Healthy Parenting As a Protective Factor for Posttraumatic Stress Disorder in Adulthood: A Case-Control Study. PLoS One, v. 9, n. 1, JAN 29 2014. (04/15039-0)

HOEXTER, MARCELO Q.; FADEL, GUSTAVO; FELICIO, ANDRE C.; CALZAVARA, MARIANA B.; BATISTA, ILZA R.; REIS, MARILIA A.; SHIH, MING C.; PITMAN, ROGER K.; ANDREOLI, SERGIO B.; MELLO, MARCELO F.; et al. Higher striatal dopamine transporter density in PTSD: an in vivo SPECT study with [Tc-99m]TRODAT-1. Psychopharmacology, v. 224, n. 2, p. 337-345, NOV 2012. (04/15039-0)

PASSARELA, CRISTIANE DE MEDEIROS; MENDES, DEISE DANIELA; MARI, JAIR DE JESUS. Revisão sistemática para estudar a eficácia de terapia cognitivo-comportamental para crianças e adolescentes abusadas sexualmente com transtorno de estresse pós-traumático. ARCHIVES OF CLINICAL PSYCHIATRY, v. 37, n. 2, p. 69-73, 2010. (04/15039-0)

ANDREOLI, SERGIO BAXTER; RIBEIRO, WAGNER SILVA; QUINTANA, MARIA INES; GUINDALINI, CAMILA; BREEN, GEROME; BLAY, SERGIO LUIS; COUTINHO, EVANDRO S. F.; HARPHAM, TRUDY; JORGE, MIGUEL ROBERTO; LARA, DIOGO RIZZATO; et al. Violence and post-traumatic stress disorder in Sao Paulo and Rio de Janeiro, Brazil: the protocol for an epidemiological and genetic survey. BMC Psychiatry, v. 9, JUN 7 2009. (04/15039-0)

BRESSAN, RODRIGO A.; QUARANTINI, LUCAS C.; ANDREOLI, SERGIO B.; ARAUJO, CELIA; BREEN, GEROME; GUINDALINI, CAMILA; HOEXTER, MARCELO; JACKOWSKI, ANDREA P.; JORGE, MIGUEL R.; LACERDA, ACIOLY L. T.; et al. The posttraumatic stress disorder project in Brazil: neuropsychological, structural and molecular neuroimaging studies in victims of urban violence. BMC Psychiatry, v. 9, JUN 1 2009. (04/15039-0)

PUPO, MARIANA CADROBBI; JORGE, MIGUEL ROBERTO; SCHOEDL, ALINE FERRI; BRESSAN, RODRIGO AFFONSECA; ANDREOLI, SERGIO BAXTER; MELLO, MARCELO FEIJO; MARI, JAIR DE JESUS. The accuracy of the Clinician-Administered PTSD Scale (CAPS) to identify PTSD cases in victims of urban violence. PSYCHIATRY RESEARCH, v. 185, n. 1-2, p. 157-160, JAN 30 2011. (04/15039-0)

RIBEIRO, WAGNER SILVA; MARI, JAIR DE JESUS; QUINTANA, MARIA INES; DEWEY, MICHAEL E.; EVANS-LACKO, SARA; PEREIRA VILETE, LILIANE MARIA; FIGUEIRA, IVAN; BRESSAN, RODRIGO AFFONSECA; DE MELLO, MARCELO FEIJO; PRINCE, MARTIN; et al. The Impact of Epidemic Violence on the Prevalence of Psychiatric Disorders in Sao Paulo and Rio de Janeiro, Brazil. PLoS One, v. 8, n. 5, MAY 8 2013. (04/15039-0)

QUINTANA, MARIA INES; MARI, JAIR DE JESUS; RIBEIRO, WAGNER SILVA; JORGE, MIGUEL ROBERTO; ANDREOLI, SERGIO BAXTER. Validade do diagnóstico de transtorno de estresse pós-traumático do Composite International Diagnostic Interview (CIDI 2.1) de acordo com os critérios diagnósticos da DSM-IV. Cadernos de Saúde Pública, v. 28, n. 7, p. 1312-1318, JUL 2012. (04/15039-0)

KALAF, JULIANA; VILETE, LILIANE MARIA PEREIRA; VOLCHAN, ELIANE; FISZMAN, ADRIANA; FREIRE COUTINHO, EVANDRO SILVA; ANDREOLI, SERGIO BAXTER; QUINTANA, MARIA INES; MARI, JAIR DE JESUS; FIGUEIRA, IVAN. Peritraumatic tonic immobility in a large representative sample of the general population: association with posttraumatic stress disorder and female gender. COMPREHENSIVE PSYCHIATRY, v. 60, p. 68-72, JUL 2015. (04/15039-0)

VILETE, LILIANE; FIGUEIRA, IVAN; ANDREOLI, SERGIO BAXTER; RIBEIRO, WAGNER; QUINTANA, MARIA INES; MARI, JAIR DE JESUS; FREIRE COUTINHO, EVANDRO SILVA. Resilience to trauma in the two largest cities of Brazil: a cross-sectional study. BMC Psychiatry, v. 14, SEP 16 2014. (04/15039-0)

QUINTANA, MARIA INES; ANDREOLI, SERGIO BAXTER; PELUFFO, MARCELA POCTICH; RIBEIRO, WAGNER SILVA; FEIJO, MARCELO M.; BRESSAN, RODRIGO AFFONSECA; COUTINHO, EVANDRO S. F.; MARI, JAIR DE JESUS. Psychotropic Drug Use in Sao Paulo, Brazil - An Epidemiological Survey. PLoS One, v. 10, n. 8, AUG 7 2015. (04/15039-0)

JAEN-VARAS, DENISSE; MARI, JAIR DE JESUS; COUTINHO, EVANDRO DA SILVA; ANDREOLI, SERGIO BAXTER; QUINTANA, MARIA INES; DE MELLO, MARCELO FEIJO; BRESSAN, RODRIGO AFFONSECA; RIBEIRO, WAGNER SILVA. A cross-sectional study to compare levels of psychiatric morbidity between young people and adults exposed to violence in a large urban center. BMC Psychiatry, v. 16, JUN 7 2016. (04/15039-0)

DA SILVA, HERIKA C.; DA ROSA, MAISA M. FURTADO; BERGER, WILLIAM; LUZ, MARIANA P.; MENDLOWICZ, MAURO; COUTINHO, EVANDRO S. F.; PORTELLA, CARLA M.; MARQUES, PAMELA I. S.; MOGRABI, DANIEL C.; FIGUEIRA, IVAN; et al. PTSD in mental health outpatient settings: highly prevalent and under-recognized. Revista Brasileira de Psiquiatria, v. 41, n. 3, p. 213-217, MAY-JUN 2019. (04/15039-0)

NINA LEÃO MARQUES VALENTE; JOSE PAULO FIKS; HOMERO VALLADA; MARCELO FEIJÓ DE MELLO. Evolucionismo e genética do transtorno de estresse pós-traumático. Revista de Psiquiatria do Rio Grande do Sul, v. 30, n. 1, p. 0-0, 2008-00-00. (04/15039-0)

MARQUES VALENTE, NINA LEAO; VALLADA, HOMERO; CORDEIRO, QUIRINO; MIGUITA, KAREN; BRESSAN, RODRIGO AFFONSECA; ANDREOLI, SERGIO BAXTER; MARI, JAIR JESUS; MELLO, MARCELO FEIJO. Candidate-Gene Approach in Posttraumatic Stress Disorder After Urban Violence: Association Analysis of the Genes Encoding Serotonin Transporter, Dopamine Transporter, and BDNF. JOURNAL OF MOLECULAR NEUROSCIENCE, v. 44, n. 1, p. 59-67, MAY 2011. (04/15039-0)

MARQUES VALENTE, NINA LEAO; VALLADA, HOMERO; CORDEIRO, QUIRINO; BRESSAN, RODRIGO AFFONSECA; ANDREOLI, SERGIO BAXTER; MARI, JAIR JESUS; MELLO, MARCELO FEIJO. Catechol-O-methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD After Urban Violence. JOURNAL OF MOLECULAR NEUROSCIENCE, v. 43, n. 3, p. 516-523, MAR 2011. (04/15039-0)

JACKOWSKI, ANDREA PAROLIN; DE ARAUJO, CELIA MARIA; TAVARES DE LACERDA, ACIOLY LUIZ; MARI, JAIR DE JESUS; KAUFMAN, JOAN. Neurostructural imaging findings in children with post-traumatic stress disorder: Brief review. PSYCHIATRY AND CLINICAL NEUROSCIENCES, v. 63, n. 1, p. 1-8, Feb. 2009. (04/15039-0)

MENDES, DEISE D.; MELLO, MARCELO FEIJO; VENTURA, PAULA; PASSARELA, CRISTIANE DE MEDEIROS; MARI, JAIR DE JESUS. A SYSTEMATIC REVIEW ON THE EFFECTIVENESS OF COGNITIVE BEHAVIORAL THERAPY FOR POSTTRAUMATIC STRESS DISORDER. The International Journal of Psychiatry in Medicine, v. 38, n. 3, p. 241-259, 2008. (04/15039-0)

SCHOEDL, ALINE F.; COSTA, MARIANA P.; FOSSALUZA, VICTOR; MARI, JAIR J.; MELLO, MARCELO F.. Specific traumatic events during childhood as risk factors for posttraumatic stress disorder development in adults. JOURNAL OF HEALTH PSYCHOLOGY, v. 19, n. 7, p. 847-857, JUL 2014. (04/15039-0)

REICHENHEIM, MICHAEL; SOUZA, WANDERSON; FREIRE COUTINHO, EVANDRO SILVA; FIGUEIRA, IVAN; QUINTANA, MARIA INES; DE MELLO, MARCELO FEIJO; BRESSAN, RODRIGO AFFONSECA; MARI, JAIR DE JESUS; ANDREOLI, SERGIO BAXTER. Structural Validity of the Tonic Immobility Scale in a Population Exposed to Trauma: Evidence from Two Large Brazilian Samples. PLoS One, v. 9, n. 4, APR 18 2014. (04/15039-0)

BALDACARA, LEONARDO; JACKOWSKI, ANDREA P.; SCHOEDL, ALINE; PUPO, MARIANA; ANDREOLI, SERGIO B.; MELLO, MARCELO F.; LACERDA, ACIOLY L. T.; MARI, JAIR J.; BRESSAN, RODRIGO A.. Reduced cerebellar left hemisphere and vermal volume in adults with PTSD from a community sample. JOURNAL OF PSYCHIATRIC RESEARCH, v. 45, n. 12, p. 1627-1633, DEC 2011. (04/15039-0)

MOREIRA, F. G.; QUINTANA, M. I.; RIBEIRO, W.; BRESSAN, R. A.; MELLO, M. F.; MARI, J. J.; ANDREOLI, S. B.. Revictimization of Violence Suffered by Those Diagnosed with Alcohol Dependence in the General Population. BIOMED RESEARCH INTERNATIONAL, 2015. (04/15039-0)

BALDACARA, LEONARDO; ZUGMAN, ANDRE; ARAUJO, CELIA; COGO-MOREIRA, HUGO; TAVARES LACERDA, ACIOLY LUIZ; SCHOEDL, ALINE; PUPO, MARIANA; MELLO, MARCELO FEIJO; ANDREOLI, SERGIO B.; MARI, JAIR DE JESUS; et al. Reduction of anterior cingulate in adults with urban violence- related PTSD. Journal of Affective Disorders, v. 168, p. 13-20, OCT 15 2014. (04/15039-0)

FLAKS, MARIANA K.; MALTA, STELLA M.; ALMEIDA, PRISCILA P.; BUENO, ORLANDO F. A.; PUPO, MARIANA C.; ANDREOLI, SERGIO B.; MELLO, MARCELO F.; LACERDA, ACIOLY L. T.; MARI, JAIR J.; BRESSAN, RODRIGO A.. Attentional and executive functions are differentially affected by post-traumatic stress disorder and trauma. JOURNAL OF PSYCHIATRIC RESEARCH, v. 48, n. 1, p. 32-39, JAN 2014. (09/01358-0, 04/15039-0)