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Cellular and molecular biology of malaria parasites

Grant number: 98/00410-2
Support type:Research Projects - Thematic Grants
Duration: November 01, 1998 - June 30, 2003
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Célia Regina da Silva Garcia
Grantee:Célia Regina da Silva Garcia
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):01/01755-8 - Studying chloroquine mechanisms of action in Plasmodium sp. using microphysiometer, BP.IC


The nature of the mechanisms underlying Ca2+ homeostasis in malaria parasites has puzzled investigators for almost two decades. Ca2+ is a ubiquitous messenger in eukaryotic cell signaling and its binding to proteins leads to changes in their activity and thus in the control of many cellular events. Our laboratory has been working with human malaria parasite, Plasmodium falciparum and the rodent parasite, Plasmodium chabaudi. The lab is set up for the study of the basic mechanisms controlling Ca2+ handling in malaria parasites which is important for understanding the physiology of these cells, but also to obtain clues as to potential role of this second messenger in signal transduction and host cell attack. We have recently extended our study of signaling transduction aspects to lizard parasites. Lizard Plasmodium occurs in Amazonia region and unlike the other Plasmodium species, it is not lethal although accounts for almost 50% of the Plasmodium species. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GAZARINI, MARCOS L.; THOMAS, ANDREW P.; POZZAN, TULLIO; GARCIA, CÉLIA R. S. Calcium signaling in a low calcium environment: how the intracellular malaria parasite solves the problem. JOURNAL OF CELL BIOLOGY, v. 161, n. 1, p. 103-110, Apr. 2003.

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