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Melatonin and the control of energy metabolism: central and peripheral actions and their interaction with other hormones

Grant number: 04/06767-2
Support type:Research Projects - Thematic Grants
Duration: January 01, 2005 - February 28, 2009
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:José Cipolla Neto
Grantee:José Cipolla Neto
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Fabio Bessa Lima ; Silvana Auxiliadora Bordin da Silva ; Solange Castro Afeche
Associated scholarship(s):09/10435-9 - In vivo and in vitro comparison of the clock gene expressions in the pineal gland under acute and synchronized noradrenergic stimulation, BP.IC
09/04308-4 - Study of the mechanisms of mitochondrial melatonin production, BP.MS
09/01128-5 - Melatonin synthesis pathway in invertebrates: presence and functional aspects, BP.DR
07/08733-6 - Insulin signaling pathways mobilized by noradrenergic stimulation on pineal gland and the differential role of alpha 1 e beta 1 adrenoreceptors, BP.IC

Abstract

The aim of this work is to study the role played by melatonin in the control of energy metabolism. Using in vivo and in vitro experiments, in intact or pinealectomized young or old animais, treated or not with melatonin, we are proposing to study the metabolic function and gene expression in the white adipose tissue, skeletal muscular system and the pancreatic B cells and the apoptosis phenomenon induced by fatty acids. Moreover, we intend to study the action of melatonin in association or not with insulin and/or leptin on cellular metabolism and gene expression in specific hypothalamic nuclei or in neurons and/or glia cells maintened in culture. The central nervous system structures to be studied are those mainly involved in the control of energy metabolism and the control of circadian rhythms. (AU)

Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AMARAL, FERNANDA G.; TURATI, ARIANE O.; BARONE, MARK; SCIALFA, JULIETA H.; BUONFIGLIO, DANIELLA DO CARMO; PERES, RAFAEL; PELICIARI-GARCIA, RODRIGO A.; AFECHE, SOLANGE C.; LIMA, LARISSA; SCAVONE, CRISTOFORO; BORDIN, SILVANA; REITER, RUSSEL J.; MENNA-BARRETO, LUIZ; CIPOLLA-NETO, JOSE. Melatonin synthesis impairment as a new deleterious outcome of diabetes-derived hyperglycemia. Journal of Pineal Research, v. 57, n. 1, p. 67-79, AUG 2014. Web of Science Citations: 26.
FERREIRA, S. G.; PELICIARI-GARCIA, R. A.; TAKAHASHI-HYODO, S. A.; RODRIGUES, A. C.; AMARAL, F. G.; BERRA, C. M.; BORDIN, S.; CURI, R.; CIPOLLA-NETO, J. Effects of melatonin on DNA damage induced by cyclophosphamide in rats. Brazilian Journal of Medical and Biological Research, v. 46, n. 3, p. 278-286, Mar. 2013. Web of Science Citations: 15.
PERES, RAFAEL; DO AMARAL, FERNANDA GASPAR; MADRIGRANO, THIAGO CARDOSO; SCIALFA, JULIETA HELENA; BORDIN, SILVANA; AFECHE, SOLANGE CASTRO; CIPOLLA-NETO, JOSE. Ethanol consumption and pineal melatonin daily profile in rats. ADDICTION BIOLOGY, v. 16, n. 4, p. 580-590, OCT 2011. Web of Science Citations: 15.
BUONFIGLIO, DANIELLA DO CARMO; PELICIARI-GARCIA, RODRIGO ANTONIO; DO AMARAL, FERNANDA GASPAR; PERES, RAFAEL; ARAUJO NOGUEIRA, TATIANE C.; AFECHE, SOLANGE CASTRO; CIPOLLA-NETO, JOSE. Early-Stage Retinal Melatonin Synthesis Impairment in Streptozotocin-Induced Diabetic Wistar Rats. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 52, n. 10, p. 7416-7422, SEP 2011. Web of Science Citations: 27.
PELICIARI-GARCIA, RODRIGO A.; MARCAL, ANDERSON C.; SILVA, JESSICA A.; CARMO-BUONFIGLIO, DANIELLA; AMARAL, FERNANDA G.; AFECHE, SOLANGE CASTRO; CIPOLLA-NETO, JOSE; CARVALHO, CARLA R. O. Insulin temporal sensitivity and its signaling pathway in the rat pineal gland. Life Sciences, v. 87, n. 5-6, p. 169-174, JUL 31 2010. Web of Science Citations: 14.
CARDOSO ALONSO-VALE, MARIA ISABEL; PERES, SIDNEY BARNABE; VERNOCHET, CECILE; FARMER, STEPHEN R.; LIMA, FABIO BESSA. Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBP beta transcriptional activity. Journal of Pineal Research, v. 47, n. 3, p. 221-227, OCT 2009. Web of Science Citations: 48.
CARDOSO ALONSO-VALE, MARIA ISABEL; ANDREOTTI, SANDRA; MUKAI, PAULA YURI; BORGES-SILVA, CRISTINA DAS NEVES; PERES, SIDNEY BARNABE; CIPOLLA-NETO, JOSE; LIMA, FABIO BESSA. Melatonin and the circadian entrainment of metabolic and hormonal activities in primary isolated adipocytes. Journal of Pineal Research, v. 45, n. 4, p. 422-429, NOV 2008. Web of Science Citations: 59.
BARBOSA‚ R.; HELENA SCIALFA‚ J.; MINGARINI TERRA‚ I.; CIPOLLA-NETO‚ J.; SIMONNEAUX‚ V.; CASTRO AFECHE‚ S. Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland. Life Sciences, v. 82, n. 9-10, p. 529-535, 2008.
GARCIA‚ R.A.P.; AFECHE‚ S.C.; SCIALFA‚ J.H.; DO AMARAL‚ F.G.; DOS SANTOS‚ S.H.J.; LIMA‚ F.B.; YOUNG‚ M.E.; CIPOLLA-NETO‚ J. Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland. Life Sciences, v. 82, n. 1-2, p. 108-114, 2008.
BORGES-SILVA, CRISTINA DAS NEVES; TAKADA, JULIE; ALONSO-VALE, MARIA ISABEL CARDOSO; PERES, SIDNEY B.; FONSECA-ALANIZ, MIRIAM H.; ANDREOTTI, SANDRA; CIPOLLA-NETO, JOSE; PITHON-CURI, TANIA C.; LIMA, FABIO BESSA. Pinealectomy reduces hepatic and muscular glycogen content and attenuates aerobic power adaptability in trained rats. Journal of Pineal Research, v. 43, n. 1, p. 96-103, Aug. 2007.

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