Advanced search
Start date
Betweenand

An integrated approach for the dissection of primary hypertension: molecular and functional characterization of the cardiovascular system

Grant number: 01/00009-0
Support type:Research Projects - Thematic Grants
Duration: September 01, 2001 - October 31, 2006
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Eduardo Moacyr Krieger
Grantee:Eduardo Moacyr Krieger
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Co-Principal Investigators:José Eduardo Krieger ; Maria Claudia Costa Irigoyen

Abstract

Cardiovascular diseases and in particular hypertension represent a major burden in terms of Public health worldwide. Hypertension is a complex disease where multiple genetic alterations influenced by a variety of environmental factors are essential for the manifestation of the phenotype. It is believed that hypertension results from an imbalance between the interplay of complex vasopressor/growth stimulating versus vasodepressor/growth inhibiting systems. Thus, one of the major challenges in the area is to dissect each component of these systems, its genes and their functional variants, their regulation, and their relative importance within this complex interplay which determines the levels of blood pressure within normal or pathological ranges throughout the life span. In this project we want to use a multidisciplinary approach with the participation of a team of researches with a wide range of expertise to address the topics listed below. All sections attempt to share the same approach aimed to integrate knowledge from DNA to bedside with more or less emphasis in cell, animal, or clinical work. (AU)

Articles published in Pesquisa FAPESP Maganize about the research grant:
Dancing genes 
Reconnected heart 

Scientific publications (49)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARAUNA, VALERIO G.; MAGALHAES, FLAVIO C.; CAMPOS, LUCIENE C. G.; REIS, ROSANA I.; KUNAPULI, SATYA P.; COSTA-NETO, CLAUDIO M.; MIYAKAWA, AYUMI A.; KRIEGER, JOSE E. Shear stress-induced Ang II AT1 receptor activation: G-protein dependent and independent mechanisms. Biochemical and Biophysical Research Communications, v. 434, n. 3, p. 647-652, MAY 10 2013. Web of Science Citations: 22.
DA PUREZA, DEMILTO YAMAGUSHI; JORGE, LUCIANA; SANCHES, IRIS CALLADO; IRIGOYEN, MARIA-CLAUDIA; DE SOUZA, ROMEU RODRIGUES; DE ANGELIS, KATIA. Acute exercise adjustments of cardiovascular autonomic control in diabetic rats. MUSCLE & NERVE, v. 46, n. 1, p. 96-101, JUL 2012. Web of Science Citations: 1.
ALVIM, RAFAEL DE OLIVEIRA; JUNIOR LIMA SANTOS, PAULO CALEB; DIAS, RODRIGO GONCALVES; RODRIGUES, MARILIZA VELHO; CUNHA, ROBERTO DE SA; MILL, JOSE GERALDO; NADRUZ JUNIOR, WILSON; KRIEGER, JOSE EDUARDO; PEREIRA, ALEXANDRE COSTA. Association between the C242T polymorphism in the p22phox gene with arterial stiffness in the Brazilian population. Physiological Genomics, v. 44, n. 10, p. 587-592, MAY 2012. Web of Science Citations: 9.
BARAUNA, VALERIO GARRONE; GASTALHO CAMPOS, LUCIENE CRISTINA; MIYAKAWA, AYUMI AUREA; KRIEGER, JOSE EDUARDO. ACE as a Mechanosensor to Shear Stress Influences the Control of Its Own Regulation via Phosphorylation of Cytoplasmic Ser(1270). PLoS One, v. 6, n. 8 AUG 25 2011. Web of Science Citations: 16.
RODRIGUES, BRUNO; ROSA, KALEIZU T.; MEDEIROS, ALESSANDRA; SCHAAN, BEATRIZ D.; BRUM, PATRICIA C.; DE ANGELIS, KATIA; IRIGOYEN, MARIA CLAUDIA. Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents. CARDIOVASCULAR DIABETOLOGY, v. 10, APR 6 2011. Web of Science Citations: 26.
WOLFF GOWDAK, LUIS HENRIQUE; SCHETTERT, ISOLMAR TADEU; ROCHITTE, CARLOS EDUARDO; FERREIRA LISBOA, LUIZ AUGUSTO; OLIVEIRA DALLAN, LUIS ALBERTO; MACHADO CESAR, LUIZ ANTONIO; DE OLIVEIRA, SERGIO ALMEIDA; KRIEGER, JOSE EDUARDO. Early Increase in Myocardial Perfusion After Stem Cell Therapy in Patients Undergoing Incomplete Coronary Artery Bypass Surgery. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, v. 4, n. 1, SI, p. 106-113, FEB 2011. Web of Science Citations: 9.
JORGE, LUCIANA; RODRIGUES, BRUNO; ROSA, KALEIZU TEODORO; MALFITANO, CHRISTIANE; ALBA LOUREIRO, TATIANA CAROLINA; MEDEIROS, ALESSANDRA; CURI, RUI; BRUM, PATRICIA CHAKUR; LACCHINI, SILVIA; MONTANO, NICOLA; DE ANGELIS, KATIA; IRIGOYEN, MARIA-CLAUDIA. Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality. EUROPEAN HEART JOURNAL, v. 32, n. 7, p. 904-912, 2011. Web of Science Citations: 34.
RODRIGUES, BRUNO; TABOAS FIGUEROA, DIEGO MENDROT; FANG, JIAO; ROSA, KALEIZU TEODORO; LLESUY, SUZANA; DE ANGELIS, KATIA; IRIGOYEN, MARIA CLAUDIA. Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents. Clinics, v. 66, n. 8, p. 1437-1442, 2011. Web of Science Citations: 9.
MOSTARDA, C.; RODRIGUES, B.; VANE, M.; MOREIRA, E. D.; ROSA, K. T.; MORAES-SILVA, I. C.; LACCHINI, S.; CASARINI, D. E.; DE ANGELIS, K.; IRIGOYEN, M. C. Autonomic impairment after myocardial infarction: Role in cardiac remodelling and mortality. Clinical and Experimental Pharmacology and Physiology, v. 37, n. 4, p. 447-452, APR 2010. Web of Science Citations: 41.
GIOLI-PEREIRA, LUCIANA; PEREIRA, ALEXANDRE COSTA; MESQUITA, SONIA M.; XAVIER-NETO, JOSE; LOPES, ANTONIO AUGUSTO; KRIEGER, JOSE EDUARDO. NKX2.5 mutations in patients with non-syndromic congenital heart disease. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 138, n. 3, p. 261-265, FEB 4 2010. Web of Science Citations: 34.
ZAMO, FERNANDA S.; LACCHINI, SILVIA; MOSTARDA, CRISTIANO; CHIAVEGATTO, SILVANA; SILVA, IVANA C. M.; OLIVEIRA, EDILAMAR MENEZES; IRIGOYEN, MARIA CLAUDIA. HEMODYNAMIC, MORPHOMETRIC AND AUTONOMIC PATTERNS IN HYPERTENSIVE RATS - RENIN-ANGIOTENSIN SYSTEM MODULATION. Clinics, v. 65, n. 1, p. 85-92, JAN 2010. Web of Science Citations: 22.
PAVAN, MARILENE; RUIZ, VIVIANE F.; SILVA, FABIO A.; SOBREIRA, TIAGO J.; CRAVO, ROBERTA M.; VASCONCELOS, MICHELLE; MARQUES, LIVIA P.; MESQUITA, SONIA M. F.; KRIEGER, JOSE E.; LOPES, ANTONIO A. B.; OLIVEIRA, PAULO S.; PEREIRA, ALEXANDRE C.; XAVIER-NETO, JOSE. ALDH1A2 (RALDH2) genetic variation in human congenital heart disease. BMC MEDICAL GENETICS, v. 10, NOV 3 2009. Web of Science Citations: 22.
GASTALHO CAMPOS, LUCIENE CRISTINA; MIYAKAWA, AYUMI AUREA; BARAUNA, VALERIO GARRONE; CARDOSO, LEANDRO; BORIN, THAIZ FERRAZ; DE OLIVEIRA DALLAN, LUIS ALBERTO; KRIEGER, JOSE EDUARDO. Induction of CRP3/MLP expression during vein arterialization is dependent on stretch rather than shear stress. Cardiovascular Research, v. 83, n. 1, p. 140-147, July 2009. Web of Science Citations: 15.
BORIN, THAIZ FERRAZ; MIYAKAWA, AYUMI AUREA; CARDOSO, LEANDRO; BORGES, LUCIANO DE FIGUEIREDO; GONCALVES, GIOVANA APARECIDA; KRIEGER, JOSE EDUARDO. Apoptosis, cell proliferation and modulation of cyclin-dependent kinase inhibitor p21(cip1) in vascular remodelling during vein arterialization in the rat. International Journal of Experimental Pathology, v. 90, n. 3, p. 328-337, June 2009. Web of Science Citations: 16.
LACCHINI, SILVIA; HEIMANN, ANDREA S.; EVANGELISTA, FABIANA S.; CARDOSO, LEANDRO; SILVA, GUSTAVO J. J.; KRIEGER, JOSE E. Cuff-induced vascular intima thickening is influenced by titration of the Ace gene in mice. Physiological Genomics, v. 37, n. 3, p. 225-230, MAY 2009. Web of Science Citations: 7.
DE ANGELIS, KATIA; IRIGOYEN, MARIA CLAUDIA; MORRIS, MARIANA. Diabetes and cardiovascular autonomic dysfunction: Application of animal models. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v. 145, n. 1-2, p. 3-10, JAN 28 2009. Web of Science Citations: 26.
ANEAS‚ I.; RODRIGUES‚ M.V.; PAULETTI‚ B.A.; SILVA‚ G.J.J.; CARMONA‚ R.; CARDOSO‚ L.; KWITEK‚ A.E.; JACOB‚ H.J.; SOLER‚ J.M.P.; KRIEGER‚ J.E. Congenic strains provide evidence that four mapped loci in chromosomes 2‚ 4‚ and 16 influence hypertension in the SHR. Physiological Genomics, v. 37, n. 1, p. 52-57, 2009.
MIYAKAWA, AYUMI AUREA; OLIVEIRA DALLAN, LUIS ALBERTO; LACCHINI, SILVIA; BORIN, THAIZ FERRAZ; KRIEGER, JOSE EDUARDO. HUMAN SAPHENOUS VEIN ORGAN CULTURE UNDER CONTROLLED HEMODYNAMIC CONDITIONS. Clinics, v. 63, n. 5, p. 683-688, OCT 2008. Web of Science Citations: 17.
BASSANEZE‚ V.; MIYAKAWA‚ A.A.; KRIEGER‚ J.E. A quantitative chemiluminescent method for studying replicative and stress-induced premature senescence in cell cultures. Analytical Biochemistry, v. 372, n. 2, p. 198-203, 2008.
H.N. SOUFEN; V.M.C. SALEMI; I.M.S. ANEAS; F.J.A. RAMIRES; A.M.D. BENÍCIO; L.A. BENVENUTI; J.E. KRIEGER; C. MADY. Collagen content, but not the ratios of collagen type III/I mRNAs, differs among hypertensive, alcoholic, and idiopathic dilated cardiomyopathy. Brazilian Journal of Medical and Biological Research, v. 41, n. 12, p. 1098-1104, Dez. 2008.
LATERZA, MATEUS C.; MATOS, LUCIANA D. N. J. DE; TROMBETTA, IVANI C.; BRAGA, ANA M. W.; ROVEDA, FABIANA; ALVES, MARIA J. N. N.; KRIEGER, EDUARDO M.; NEGRÃO, CARLOS E.; RONDON, MARIA U. P. B. Exercise training restores baroreflex sensitivity in never-treated hypertensive patients. Hypertension, v. 49, n. 6, p. 1298-1306, June 2007.
ALVES‚ M.J.N.N.; RONDON‚ M.U.P.B.; SANTOS‚ A.C.; DIAS‚ R.G.; BARRETTO‚ A.C.P.; KRIEGER‚ E.M.; MIDDLEKAUFF‚ H.R.; NEGRÃO‚ C.E. Sympathetic nerve activity restrains reflex vasodilatation in heart failure. CLINICAL AUTONOMIC RESEARCH, v. 17, n. 6, p. 364-369, 2007.
CUNHA‚ T.S.; FARAH‚ V.; PAULINI‚ J.; PAZZINE‚ M.; ELASED‚ K.M.; MARCONDES‚ F.K.; CLÁUDIA IRIGOYEN‚ M.; DE ANGELIS‚ K.; MIRKIN‚ L.D.; MORRIS‚ M. Relationship between renal and cardiovascular changes in a murine model of glucose intolerance. Regulatory Peptides, v. 139, n. 1, p. 1-4, 2007.
SILVA‚ G.; PEREIRA‚ A.; KRIEGER‚ E.; KRIEGER‚ J. Genetic mapping of a new heart rate QTL on chromosome 8 of spontaneously hypertensive rats. BMC MEDICAL GENETICS, v. 8, n. 1, p. 17, 2007.
WICHI‚ R.; MALFITANO‚ C.; ROSA‚ K.; DE SOUZA‚ S.B.; SALEMI‚ V.; MOSTARDA‚ C.; DE ANGELIS‚ K.; IRIGOYEN‚ M.C. Noninvasive and invasive evaluation of cardiac dysfunction in experimental diabetes in rodents. CARDIOVASCULAR DIABETOLOGY, v. 6, n. 1, p. 14, 2007.
N.P.L. ROLIM; K.C. MATTOS; P.C. BRUM; M.V.C. BALDO; H.R. MIDDLEKAUFF; C.E. NEGRÃO. The decreased oxygen uptake during progressive exercise in ischemia-induced heart failure is due to reduced cardiac output rate. Brazilian Journal of Medical and Biological Research, v. 39, n. 2, p. -, Fev. 2006.
EVANGELISTA‚ F.S.A.; KRIEGER‚ J.E. Small gene effect and exercise training-induced cardiac hypertrophy in mice: an Ace gene dosage study. Physiological Genomics, v. 27, n. 3, p. 231-236, 2006.
GIOLI-PEREIRA‚ L.; PEREIRA‚ AC; MESQUITA‚ SM; LOPES‚ AA; KRIEGER‚ JE. PCR screening for 22q11. 2 microdeletion: development of a new cost-effective diagnostic tool. Clinica Chimica Acta, v. 369, n. 1, p. 78-81, 2006.
N.P.L. ROLIM; K.C. MATTOS; P.C. BRUM; M.V.C. BALDO; H.R. MIDDLEKAUFF; C.E. NEGRÃO. The decreased oxygen uptake during progressive exercise in ischemia-induced heart failure is due to reduced cardiac output rate. Brazilian Journal of Medical and Biological Research, v. 39, n. 2, p. 297-304, Fev. 2006.
SILVA‚ G.J.J.; MOREIRA‚ E.D.; PEREIRA‚ A.C.; MILL‚ J.G.; KRIEGER‚ E.M.; KRIEGER‚ J.E. ACE gene dosage modulates pressure-induced cardiac hypertrophy in mice and men. Physiological Genomics, v. 27, n. 3, p. 237-244, 2006.
SANTOS, AMILTON C.; ALVES, MARIA J. N. N.; RONDON, MARIA U. P. B.; BARRETTO, ANTONIO C. P.; MIDDLEKAUFF, HOLLY R.; NEGRÃO, CARLOS E. Sympathetic activation restrains endothelium-mediated muscle vasodilatation in heart failure patients. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 289, n. 2, p. H593-H599, Aug. 2005.
SIMÕES-COSTA, MARCOS S.; VASCONCELOS, MICHELLE; SAMPAIO, ALLYSSON C.; CRAVO, ROBERTA M.; LINHARES, VANIA L.; HOCHGREB, TATIANA; YAN, CHAO Y. I.; DAVIDSON, BRAD; XAVIER-NETO, JOSÉ. The evolutionary origin of cardiac chambers. Developmental Biology, v. 277, n. 1, p. 1-15, Jan. 2005.
HEIMANN‚ AS; FAVARATO‚ MH; GOZZO‚ FC; RIOLI‚ V.; CARRENO‚ FR; EBERLIN‚ MN; FERRO‚ ES; KREGE‚ JH; KRIEGER‚ JE. ACE gene titration in mice uncovers a new mechanism for ACE on the control of body weight. Physiological Genomics, v. 20, n. 2, p. 173-182, 2005.
OTTO, M. E. B.; CONSOLIM-COLOMBO, F. M.; RODRIGUES SOBRINHO, C. R. M.; KRIEGER, E. M. Pressure and time dependence of the cardiopulmonary reflex response in patients with hypertensive cardiomyopathy. Brazilian Journal of Medical and Biological Research, v. 37, n. 11, p. 1615-1622, Nov. 2004.
A.W.S. HILSDORF; J.E. KRIEGER. Restriction site heteroplasmy in the mitochondrial DNA of Brycon opalinus (Cuvier, 1819) (Characiformes, Characidae, Bryconiae). Brazilian Journal of Medical and Biological Research, v. 37, n. 3, p. 307-310, Mar. 2004.
J. XAVIER-NETO; A.C. PEREIRA; E.M. OLIVEIRA; A.A. MIYAKAWA; M.L. JUNQUEIRA; J.E. KRIEGER. Control of the rat angiotensin I converting enzyme gene by CRE-like sequences. Brazilian Journal of Medical and Biological Research, v. 37, n. 10, p. 1441-1453, Out. 2004.
MIYAKAWA‚ A.A.; DE LOURDES JUNQUEIRA‚ M.; KRIEGER‚ J.E. Identification of two novel shear stress responsive elements in rat angiotensin I converting enzyme promoter. Physiological Genomics, v. 17, n. 2, p. 107-113, 2004.
PEREIRA‚ A.C.; PEREIRA‚ A.B.; MOTA‚ G.F.; CUNHA‚ R.S.; HERKENHOFF‚ F.L.; POLLAK‚ M.R.; MILL‚ J.G.; KRIEGER‚ J.E. NPHS2 R229Q functional variant is associated with microalbuminuria in the general population. Kidney International, v. 65, n. 3, p. 1026-1030, 2004.
PEREIRA‚ A.C.; SCHETTERT‚ I.T.; MORANDINI FILHO‚ A.A.F.; GUERRA-SHINOHARA‚ E.M.; KRIEGER‚ J.E. Methylenetetrahydrofolate reductase (MTHFR) c677t gene variant modulates the homocysteine folate correlation in a mild folate-deficient population. Clinica Chimica Acta, v. 340, n. 1, p. 99-105, 2004.
ROVEDA, FABIANA; MIDDLEKAUFF, HOLLY R.; RONDON, MARIA URBANA P. B.; REIS, SORAYA F.; SOUZA, MÁRCIO; NASTARI, LUCIANO; BARRETTO, ANTONIO CARLOS P.; KRIEGER, EDUARDO M.; NEGRÃO, CARLOS EDUARDO. The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trial. Journal of the American College of Cardiology, v. 42, n. 5, p. 854-860, Sept. 2003.
C.M. PERTRINI; A.A. MIYAKAWA; F.R.M. LAURINDO; J.E. KRIEGER. Nitric oxide regulates angiotensin-I converting enzyme under static conditions but not under shear stress. Brazilian Journal of Medical and Biological Research, v. 36, n. 9, p. 1175-1178, Set. 2003.
F.S. EVANGELISTA; P.C. BRUM; J.E. KRIEGER. Duration-controlled swimming exercise training induces cardiac hypertrophy in mice. Brazilian Journal of Medical and Biological Research, v. 36, n. 12, p. 1751-1759, Dez. 2003.
HOCHGREB‚ T.; LINHARES‚ V.L.; MENEZES‚ D.C.; SAMPAIO‚ A.C.; YAN‚ C.Y.I.; CARDOSO‚ W.V.; ROSENTHAL‚ N.; XAVIER-NETO‚ J. A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field. DEVELOPMENT, v. 130, n. 22, p. 5363-5374, 2003.
PEREIRA‚ A.C.; FLORIANO‚ M.S.; MOTA‚ G.F.A.; CUNHA‚ R.S.; HERKENHOFF‚ F.L.; MILL‚ J.G.; KRIEGER‚ J.E. β2 adrenoceptor functional gene variants‚ obesity‚ and blood pressure level interactions in the general population. Hypertension, v. 42, n. 4, p. 685-692, 2003.
PEREIRA‚ A.C.; MOTA‚ G.F.A.; CUNHA‚ R.S.; HERBENHOFF‚ F.L.; MILL‚ J.G.; KRIEGER‚ J.E. Angiotensinogen 235T allele “dosage” is associated with blood pressure phenotypes. Hypertension, v. 41, n. 1, p. 25-30, 2003.
RONDON, MARIA URBANA P. BRANDÃO; ALVES, MARIA JANIEIRE N. N.; BRAGA, ANA MARIA F. W.; TEIXEIRA, ODILA TOMOKO U. N.; BARRETTO, ANTONIO CARLOS P.; KRIEGER, EDUARDO M.; NEGRÃO, CARLOS EDUARDO. Postexercise blood pressure reduction in elderly hypertensive patients. Journal of the American College of Cardiology, v. 39, n. 4, p. 676-682, Feb. 2002.
A.C. PEREIRA; G.A. MOTA; I. BENSEÑOR; P.A. LOTUFO; J.E. KRIEGER. Effect of race, genetic population structure, and genetic models in two-locus association studies: clustering of functional renin-angiotensin system gene variants in hypertension association studies. Brazilian Journal of Medical and Biological Research, v. 34, n. 11, p. 1421-1428, Nov. 2001.
XAVIER-NETO‚ J.; ROSENTHAL‚ N.; SILVA‚ F.A.; MATOS‚ T.G.F.; HOCHGREB‚ T.; LINHARES‚ V.L.F. Retinoid signaling and cardiac anteroposterior segmentation. GENESIS, v. 31, n. 3, p. 97-104, 2001.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.