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Leishmaniasis in Brazil: clinical and immunopathogenetic aspects of the human and experimental disease

Abstract

The ACL presents a large spectrum of manifestation, varying from asymptomatic and/or sub clinical in resistant individuals till different forms in susceptible individuals, such as localized cutaneous Leishmaniasis (LCL), borderline disseminated cutaneous Leishmaniasis (BDCL), mucocutaneous leishmaniasis (MCL), mucosal leishmaniasis (ML) and anergic diffuse cutaneous leishmaniasis (ADCL), depending to the species and the host immunoresponse (TCD4+ Th1/Th2). The AVL in spite of the advances of knowledge about the classic form, there are still many gaps in relation to the parasite, L. (L.) chagasi, and the human immunegenitic system. The clinical spectrum of the human infection still needs more precise definition to improve the clinical diagnosis of infected, symptomatic and asymptomatic individuals, as well as suitable treatment for the different forms. Longitudinal field studies are needed for identification of only infected, symptomatic and asymptomatic individuals. Long-term follow up for identification of the clinical immunological patterns of the human infection by L. (L.) chagasi is also needed. The human immune response to infection by L. (L.) chagasi has had more attention in the classical form than in the symptomatic and/or sub clinical forms, in which immunological resistance needs more knowledge. Experimental models for AVL are usually made in hamsters and mice, which data are not fully transferred to man due to philogenetic distance, which make necessary the development of a suitable experimental model closer to man. The Cebus apella, has shown potentially a viable model for in vitro immune response studies using experimental infection in peritoneal macrophages for AVL and ACL species of Leishmania in Brazil. The models of non-human primates, in vivo and in vitro, may be useful to immunopathogenical studies either for AVL or ACL. The project aim the characterization of role the Langherans cells in the CD4/CD8 immune response in the different clinical forms of the Brazilian ACL and different species in the immunopathogenetics modulation; as well as characterization of the clinical and immunological spectrum of the human infection by Leishmania (L.) chagasi in the Brazilian Amazon region, together with the humoral and cellular immune response of the infected individuals. It also proposed the evaluation of the susceptibility of the Cebus apella as experimental model for experimental visceral leishmaniasis, Leishmania (L.) chagasi, and cutaneous leishmaniasis by Leishmania (V.) braziliensis e L. (L.) amazonensis. ln relation to murine experimental model we proposed the kinetic analyses of Langherans cells interaction with the CD4+/CD8+ immune response in mice BALB/C e C57BL/6 by L. (V.) braziliensis and L. (L.) amazonensis isolated from different clinical of ACL. Mechanisms of resistance and susceptibility associated to the innate immune response of peritoneal macrophages from infected neotropicals primates with Leishmania (V.) braziliensis, L. (L.) amazonensis and L. (L.) chagasi will also be studied. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Study identifies clinical-immunological profiles of visceral leishmaniasis infection 

Scientific publications (16)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CASTRO GOMES, CLAUDIA MARIA; TEIXEIRA SOUSA, MARIA GLORIA; BEZERRA MENEZES, JOYCE PRIETO; BATISTA, MARLIANE CAMPOS; STOCCO LIMA, ANA CAROLINA; BELDA, JR., WALTER; BRADSHAW, DANIEL; ALVES GAMA, MONICA ELINOR; LAURENTI, MARCIA DALASTRA; SILVEIRA, FERNANDO TOBIAS; PEREIRA CORBETT, CARLOS EDUARDO. Immunopathological characterization of human cutaneous leishmaniasis lesions caused by Leishmania (Viannia) spp. in Amazonian Brazil. Parasitology Research, v. 116, n. 5, p. 1423-1431, MAY 2017. Web of Science Citations: 2.
CARVALHO, A. K.; CARVALHO, K.; PASSERO, L. F. D.; SOUSA, M. G. T.; DA MATTA, V. L. R.; GOMES, C. M. C.; CORBETT, C. E. P.; KALLAS, G. E.; SILVEIRA, F. T.; LAURENTI, M. D. Differential Recruitment of Dendritic Cells Subsets to Lymph Nodes Correlates with a Protective or Permissive T-Cell Response during Leishmania (Viannia) Braziliensis or Leishmania (Leishmania) Amazonensis Infection. Mediators of Inflammation, 2016. Web of Science Citations: 6.
RAMOS, PATRICIA KARLA; CARVALHO, KARINA INACIO; ROSA, DANIELA SANTORO; RODRIGUES, ANA PAULA; LIMA, LUCIANA VIEIRA; CAMPOS, MARLIANE BATISTA; GOMES, CLAUDIA MARIA C.; LAURENTI, MARCIA DALASTRA; CORBETT, CARLOS EDUARDO; SILVEIRA, FERNANDO TOBIAS. Serum Cytokine Responses over the Entire Clinical-Immunological Spectrum of Human Leishmania (L.) infantum chagasi Infection. BIOMED RESEARCH INTERNATIONAL, 2016. Web of Science Citations: 4.
DO REGO LIMA, LUCIANA VIEIRA; SANTOS RAMOS, PATRICIA KARLA; CAMPOS, MARLIANE BATISTA; DOS SANTOS, THIAGO VASCONCELOS; DE CASTRO GOMES, CLAUDIA MARIA; LAURENTI, MARCIA DALASTRA; PEREIRA CORBETT, CARLOS EDUARDO; SILVEIRA, FERNANDO TOBIAS. Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L.) infantum chagasi-infection. PATHOGENS AND GLOBAL HEALTH, v. 108, n. 8, p. 381-384, DEC 2014. Web of Science Citations: 3.
RODRIGUES, F. M. D.; COELHO NETO, G. T.; MENEZES, J. G. P. B.; GAMA, M. E. A.; GONCALVES, E. G.; SILVA, A. R.; LAURENTI, M. D.; CORBETT, C. E. P.; SILVEIRA, F. T.; GOMES, C. M. C. Expression of Foxp3, TGF-beta and IL-10 in American cutaneous leishmaniasis lesions. ARCHIVES OF DERMATOLOGICAL RESEARCH, v. 306, n. 2, p. 163-171, MAR 2014. Web of Science Citations: 12.
LAURENTI, MARCIA DALASTRA; DOMINGUES PASSERO, LUIZ FELIPE; TOMOKANE, THAISE YUMIE; FRANCESQUINI, FERNANDA DE CAMARGO; ROCHA, MUSSYA CISOTTO; DE CASTRO GOMES, CLAUDIA MARIA; PEREIRA CORBETT, CARLOS EDUARDO; SILVEIRA, FERNANDO TOBIAS. Dynamic of the Cellular Immune Response at the Dermal Site of Leishmania (L.) amazonensis and Leishmania (V.) braziliensis Infection in Sapajus apella Primate. BIOMED RESEARCH INTERNATIONAL, 2014. Web of Science Citations: 4.
ALVES GAMA, MONICA ELINOR; DE CASTRO GOMES, CLAUDIA MARIA; SILVEIRA, FERNANDO TOBIAS; LAURENTI, MARCIA DALASTRA; GONCALVES, ELOISA DA GRACA; DA SILVA, ANTONIO RAFAEL; PEREIRA CORBETT, CARLOS EDUARDO. Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features. Revista da Sociedade Brasileira de Medicina Tropical, v. 46, n. 6, p. 741-745, NOV-DEC 2013. Web of Science Citations: 7.
CARVALHO, A. K.; SILVEIRA, F. T.; PASSERO, L. F. D.; GOMES, C. M. C.; CORBETT, C. E. P.; LAURENTI, M. D. Leishmania (V.) braziliensis and L. (L.) amazonensis promote differential expression of dendritic cells and cellular immune response in murine model. PARASITE IMMUNOLOGY, v. 34, n. 8-9, p. 395-403, AUG-SEP 2012. Web of Science Citations: 16.
CARNEIRO, LILIANE ALMEIDA; LAURENTI, MARCIA DALASTRA; CAMPOS, MARLIANE BATISTA; DE CASTRO GOMES, CLAUDIA MARIA; PEREIRA CORBETT, CARLOS EDUARDO; SILVEIRA, FERNANDO TOBIAS. SUSCEPTIBILITY OF PERITONEAL MACROPHAGE FROM DIFFERENT SPECIES OF NEOTROPICAL PRIMATES TO EX VIVO Leishmania (L.) infantum chagasi-INFECTION. Revista do Instituto de Medicina Tropical de São Paulo, v. 54, n. 2, p. 95-101, MAR-APR 2012. Web of Science Citations: 4.
CARNEIRO, LILIANE ALMEIDA; SILVEIRA, FERNANDO TOBIAS; CAMPOS, MARLIANE BATISTA; DE OLIVEIRA BRIGIDO, MARIA DO CARMO; GOMES, CLAUDIA MARIA C.; CORBETT, CARLOS E. P.; LAURENTI, MARCIA D. SUSCEPTIBILITY OF Cebus apella MONKEY (PRIMATES: CEBIDAE) TO EXPERIMENTAL Leishmania (L.) infantum chagasi-INFECTION. Revista do Instituto de Medicina Tropical de São Paulo, v. 53, n. 1, p. 45-50, JAN-FEB 2011. Web of Science Citations: 3.
DE LIMA, ANA CAROLINA S.; ZAMPIERI, RICARDO A.; TOMOKANE, THAISE Y.; LAURENTI, MARCIA D.; SILVEIRA, FERNANDO T.; CORBETT, CARLOS E. P.; FLOETER-WINTER, LUCILE M.; GOMES, CLAUDIA M. C. Leishmania sp identification by PCR associated with sequencing of target SSU rDNA in paraffin-embedded skin samples stored for more than 30 years. Parasitology Research, v. 108, n. 6, p. 1525-1531, 2011. Web of Science Citations: 10.
SILVEIRA, FERNANDO T.; LAINSON, RALPH; CRESCENTE, JOSE ANGELO; DE SOUZA, ADELSON A. A.; CAMPOS, MARLIANE B.; GOMES, CLAUDIA M. C.; LAURENTI, MARCIA D.; CORBETT, CARLOS E. P. A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L.) infantum chagasi infection in the Brazilian Amazon region. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 104, n. 8, p. 529-535, AUG 2010. Web of Science Citations: 18.
SILVEIRA, FERNANDO TOBIAS; LAINSON, RALPH; ALMEIDA DE SOUZA, ADELSON ALCIMAR; CAMPOS, MARLIANE BATISTA; CARNEIRO, LILIANE ALMEIDA; REGO LIMA, LUCIANA VIEIRA; SANTOS RAMOS, PATRICIA KARLA; DE CASTRO GOMES, CLAUDIA MARIA; LAURENTI, MARCIA DALASTRA; PEREIRA CORBETT, CARLOS EDUARDO. Further evidences on a new diagnostic approach for monitoring human Leishmania (L.) infantum chagasi infection in Amazonian Brazil. Parasitology Research, v. 106, n. 2, p. 377-386, JAN 2010. Web of Science Citations: 6.
CRESCENTE, JOSE ANGELO B.; SILVEIRA, FERNANDO T.; LAINSON, RALPH; GOMES, CLAUDIA M. C.; LAURENTI, MARCIA D.; CORBETT, CARLOS E. P. A cross-sectional study on the clinical and immunological spectrum of human Leishmania (L.) infantum chagasi infection in the Brazilian Amazon region. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 103, n. 12, p. 1250-1256, DEC 2009. Web of Science Citations: 13.
SILVEIRA, FERNANDO T.; LAINSON, RALPH; PEREIRA, ELZA A.; DE SOUZA, ADELSON A. A.; CAMPOS, MARLIANE B.; CHAGAS, EUGENIA J.; GOMES, CLAUDIA M. C.; LAURENTI, MARCIA D.; CORBETT, CARLOS E. P. A longitudinal study on the transmission dynamics of human Leishmania (Leishmania) infantum chagasi infection in Amazonian Brazil, with special reference to its prevalence and incidence. Parasitology Research, v. 104, n. 3, p. 559-567, FEB 2009. Web of Science Citations: 15.
SILVEIRA, F. T.; LAINSON, R.; GOMES, C. M. DE CASTRO; LAURENTI, M. D.; CORBETT, C. E. P. Immunopathogenic competences of Leishmania (V.) braziliensis and L. (L.) amazonensis in American cutaneous leishmaniasis. PARASITE IMMUNOLOGY, v. 31, n. 8, p. 423-431, 2009. Web of Science Citations: 106.

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