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Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters

Abstract

Population assays have consistently shown that the HDL concentration is inversely related to the incidence of cardiovascular disease and plays a protective role that is far more important than LDL as a risk factor. Although the atherogenic mechanisms of LDL have been extensively exploited in vitro and in vivo, the precise antiatherogenic mechanisms attributed to HDL are incompletely understood. A likely possibility is its role on the reverse cholesterol transport system whereby cholesterol from peripheral tissues (including the arterial wall) is taken up by the liver and excreted in bile. Taking into account that the control of the cholesterol metabolism in the body ought to vary more as a function of HDL than of LDL, that blood monocytes reflect the rates of boy cholesterol synthesis, and that there is a direct relationship between the latter and the intestinal absorption of cholesterol, the present project aims at quantifying the influence of the plasma concentration of HDL and its subfractions on the whole body cholesterol economy measured as: 1) the expression of cell receptors that transport cholesterol across the membrane for export; 2) cell production of cholesterol and uptake of lipoproteins containing apoB; 3) plasma markers of cholesterol body synthesis and intestinal cholesterol absorption. These objectives are attained measuring the parameters that regulate cholesterol metabolism in freshly collected blood Iympho-monocytes and the plasma steroids that are markers of synthesis (Iathosterol/desmosterol) and of the intestinal absorption (phytosterols/cholestanol). These parameters will be related to the degree of carotid intimal thickness measured by echo-color Doppler ultrasonography. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
HDL influences cholesterol synthesis and absorption 

Scientific publications (16)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ZAGO, VANESSA H. S.; PARRA, ELIANE S.; VIRGINIO, VITOR W. M.; VENDRAME, FELIPE; GOMES, ERICA I. L.; SCHERRER, DANIEL Z.; MARSON, FERNANDO A. L.; DE FARIA, ELIANA C. Lipase C, Hepatic Type-250A/G (rs2070895) Variant Enhances Carotid Atherosclerosis in Normolipidemic and Asymptomatic Individuals from Brazil. LIPIDS, v. 55, n. 3 MAR 2020. Web of Science Citations: 0.
DE LIMA-JUNIOR, JOSE CARLOS; VIRGINIO, VITOR W. M.; MOURA, FILIPE A.; BERTOLAMI, ADRIANA; BERTOLAMI, MARCELO; COELHO-FILHO, OTAVIO R.; ZANOTTI, ILARIA; NADRUZ, WILSON; DE FARIA, ELIANA COTTA; DE CARVALHO, LUIZ SERGIO F.; SPOSITO, ANDREI C. Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 30, n. 2, p. 254-264, FEB 10 2020. Web of Science Citations: 0.
ÉRICA IVANA LÁZARO GOMES; VANESSA HELENA DE SOUZA ZAGO; ELIANA COTTA DE FARIA. Evaluation of Lipid Profiles of Children and Youth from Basic Health Units in Campinas, SP, Brazil: A Cross-Sectional Laboratory Study. Arquivos Brasileiros de Cardiologia, v. 114, n. 1, p. 47-56, Jan. 2020.
LAZARO GOMES, ERICA IVANA; DE SOUZA ZAGO, VANESSA HELENA; DE FARIA, ELIANA COTTA. Evaluation of Lipid Profiles of Children and Youth from Basic Health Units in Campinas, SP, Brazil: A Cross-Sectional Laboratory Study. Arquivos Brasileiros de Cardiologia, v. 114, n. 1, p. 47-55, JAN 2020. Web of Science Citations: 1.
ÉRICA IVANA LÁZARO GOMES; VANESSA HELENA DE SOUZA ZAGO; ELIANA COTTA DE FARIA. Evaluation of Lipid Profiles of Children and Youth from Basic Health Units in Campinas, SP, Brazil: A Cross-Sectional Laboratory Study. Arquivos Brasileiros de Cardiologia, n. ahead, p. -, 2019.
ALEXANDRE, F.; ZAGO, V. H. S.; PANZOLDO, N. B.; PARRA, E. S.; SCHERRER, D. Z.; VENDRAME, F.; NUNES, V. S.; GOMES, E. I. L.; MARCATO, P. D.; NAKANDAKARE, E. R.; QUINTAO, E. C. R.; DE FARIA, E. C. Reference values for high-density lipoprotein particle size and volume by dynamic light scattering in a Brazilian population sample and their relationships with metabolic parameters. Clinica Chimica Acta, v. 442, p. 63-72, MAR 10 2015. Web of Science Citations: 1.
VIRGINIO, V. W. M.; NUNES, V. S.; MOURA, F. A.; MENEZES, F. H.; ANDREOLLO, N. A.; ROGERIO, F.; SCHERRER, D. Z.; QUINTAO, E. C. R.; NAKANDAKARE, E.; PETRUCCI, O.; NADRUZ-JUNIOR, W.; DE FARIA, E. C.; SPOSITO, A. C. Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic infl ammatory activity. Free Radical Research, v. 49, n. 2, p. 199-203, FEB 2015. Web of Science Citations: 14.
PARRA, ELIANE SOLER; PANZOLDO, NATALIA BARATELLA; DE SOUZA ZAGO, VANESSA HELENA; SCHERRER, DANIEL ZANETTI; ALEXANDRE, FERNANDA; BAKKARAT, JAMAL; NUNES, VALERIA SUTTI; NAKANDAKARE, EDNA REGINA; ROCHA QUINTAO, EDER CARLOS; NADRUZ-, JR., WILSON; DE FARIA, ELIANA COTTA; SPOSITO, ANDREI C. HDL Size is More Accurate than HDL Cholesterol to Predict Carotid Subclinical Atherosclerosis in Individuals Classified as Low Cardiovascular Risk. PLoS One, v. 9, n. 12 DEC 3 2014. Web of Science Citations: 3.
DE SOUZA ZAGO, VANESSA HELENA; TANUS-SANTOS, JOSE EDUARDO; GARDIN DANELON, MIRIAN REGINA; PARRA, ELIANE SOLER; ALEXANDRE, FERNANDA; VIEIRA, ISABELA CALANCA; PANZOLDO, NATALIA BARATELLA; D'ALEXANDRI, FABIO LUIS; ROCHA QUINTAO, EDER CARLOS; DE FARIA, ELIANA COTTA. Chemical modification of high density lipoprotein subfractions - HDL2 and HDL3 - after use of atorvastatin. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, v. 52, n. 4, p. 277-283, APR 2014. Web of Science Citations: 2.
LEANCA, CAMILA C.; NUNES, VALERIA S.; PANZOLDO, NATALIA B.; ZAGO, VANESSA S.; PARRA, ELIANE S.; CAZITA, PATRICIA M.; JAUHIAINEN, MATTI; PASSARELLI, MARISA; NAKANDAKARE, EDNA R.; DE FARIA, ELIANA C.; QUINTAO, EDER C. R. Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects. CARDIOVASCULAR DIABETOLOGY, v. 12, NOV 22 2013. Web of Science Citations: 10.
LEANCA, C. C.; NUNES, V. S.; NAKANDAKARE, E. R.; DE FARIA, E. C.; QUINTAO, E. C. R. Does plasma HDL-C concentration interact with whole-body cholesterol metabolism?. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 23, n. 4, p. 279-284, APR 2013. Web of Science Citations: 3.
ELIANE SOLER PARRA; VANESSA HELENA DE SOUZA ZAGO; NATÁLIA BARATELLA PANZOLDO; FERNANDA ALEXANDRE; FELIPE VENDRAME; VITOR WILSON DE MOURA VIRGINIO; ISABELA CALANCA VIEIRA; MARCELO SCARPARI DUTRA RODRIGUES; ANGELA DE SOUZA CASSOL; FABIO D'ALEXANDRI; VERA SYLVIA CASTANHO; RUI NAKAMURA; JAMAL BARACAT; MIRIAN REGINA GARDIN DANELON; RONISE CARLA SASS POZETI; ANA CÂNDIDA COUTINHO FACIN; HILDA MARIA DA SILVA HONORIO; SIMONE DE CÁSSIA DIAS MESQUITA; MARCIO JORGE DA SILVA; MARIELZA CROSGNAC FERES LOT; VALÉRIA SUTTI NUNES; CAMILA CANTEIRO LEANÇA; EDNA REGINA NAKANDAKARE; EDER CARLOS ROCHA QUINTÃO; ELIANA COTTA DE FARIA. Development of a clinical laboratory data base of hyper and hypo alpha lipoproteins in Campinas-SP and neighboring region. Jornal Brasileiro de Patologia e Medicina Laboratorial, v. 49, n. 1, p. 26-33, Fev. 2013.
FERREIRA, PAOLLA F. C.; ZAGO, VANESSA H. S.; D'ALEXANDRI, FABIO L.; PANZOLDO, NATALIA B.; GIDLUND, MAGNUS A.; NAKAMURA, RUI T.; SCHREIBER, ROBERTO; PARRA, ELIANE S.; SANTIAGO, FERNANDA D.; NAKANDAKARE, EDNA R.; QUINTAO, EDER C. R.; DE FARIA, ELIANA C. Oxidized low-density lipoproteins and their antibodies: Relationships with the reverse cholesterol transport and carotid atherosclerosis in adults without cardiovascular diseases. Clinica Chimica Acta, v. 413, n. 19-20, p. 1472-1478, OCT 9 2012. Web of Science Citations: 3.
PARRA, ELIANE SOLER; PANZOLDO, NATALIA BARATELLA; KAPLAN, DENISE; FRANCO DE OLIVEIRA, HELENA COUTINHO; DOS SANTOS, JOSE ERNESTO; FERNANDES DE CARVALHO, LUIZ SERGIO; SPOSITO, ANDREI CARVALHO; GIDLUND, MAGNUS; NAKAMURA, RUY TSUTOMU; DE SOUZA ZAGO, VANESSA HELENA; NAKANDAKARE, EDNA REGINA; ROCHA QUINTAO, EDER CARLOS; DE FARIA, ELIANA COTTA. The I405V and Taq1B polymorphisms of the CETP gene differentially affect sub-clinical carotid atherosclerosis. LIPIDS IN HEALTH AND DISEASE, v. 11, OCT 5 2012. Web of Science Citations: 4.
NUNES, V. S.; LEANCA, C. C.; PANZOLDO, N. B.; PARRA, E.; CAZITA, P. M.; NAKANDAKARE, E. R.; DE FARIA, E. C.; QUINTAO, E. C. R. HDL-C concentration is related to markers of absorption and of cholesterol synthesis: Study in subjects with low vs. high HDL-C. Clinica Chimica Acta, v. 412, n. 1-2, p. 176-180, JAN 14 2011. Web of Science Citations: 18.
QUINTAO, EDER C. R.; CAZITA, PATRICIA M. Lipid transfer proteins: Past, present and perspectives. ATHEROSCLEROSIS, v. 209, n. 1, p. 1-9, MAR 2010. Web of Science Citations: 31.

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