The role of Regulatory T cells in the modulation of tumorigenesis of actinic cheilitis and oral squamous cell carcinoma: correlation between clinical behavior and prognosis

• Grant number: 06/04264-9
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2007
• End date: July 31, 2009
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Ana Paula Campanelli
• Grantee: Ana Paula Campanelli
• Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil

Abstract

CD4+CD25+ cells are the most important cells in the control of immune response against self-antigens and contribute to peripherical tolerance. These cells also control the response to bacteria, virus, parasites and fungi, playing a critical role in preservation of the infectious agent. Recent data have shown that the mechanisms of peripherical tolerance, mediated by regulatory T cells also avoid an efficient anti-tumoral response, even in those situations when the tumoral antigens can be recognized. Despite the rapid increase in mechanistic knowledge about Treg, much remains to be learned, including (a) the mechanisms by which Treg control lymphocyte effector functions; (b) whether their primary actions are on lymphocytes or APC (or both); (c) the nature of their natural ligands; and (d) the mechanisms by which Treg control tumor development. Thus, in the present study we investigated the significance of intratumoral Treg cells in the regulation of the local immune response in actinic cheilitis and oral squamous cell carcinoma. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GASPAROTO, THAIS HELENA; DE SOUZA MALASPINA, TATIANA SALLES; DAMANTE, JOSE HUMBERTO; DE MELLO, JR., EDGARD FRANCO; VALERIO IKOMA, MAURA ROSANE; GARLET, GUSTAVO POMPERMAIER; SALES NOGUEIRA COSTA, MARIA RENATA; CAVASSANI, KAREN ANGELICA; DA SILVA, JOAO SANTANA; CAMPANELLI, ANA PAULA. Regulatory T cells in the actinic cheilitis. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 43, n. 10, p. 754-760, NOV 2014. (06/04264-9, 09/14127-7)

GASPAROTO, THAIS HELENA; DE SOUZA MALASPINA, TATIANA SALLES; BENEVIDES, LUCIANA; FRANCO DE MELO, JR., EDGARD JOSE; SALES NOGUEIRA COSTA, MARIA RENATA; DAMANTE, JOSE HUMBERTO; VALERIO IKOMA, MAURA ROSANE; GARLET, GUSTAVO POMPERMAIER; CAVASSANI, KAREN ANGELICA; DA SILVA, JOAO SANTANA; et al. Patients with oral squamous cell carcinoma are characterized by increased frequency of suppressive regulatory T cells in the blood and tumor microenvironment. CANCER IMMUNOLOGY IMMUNOTHERAPY, v. 59, n. 6, p. 819-828, JUN 2010. (06/04264-9)