Advanced search
Start date
Betweenand

Etiological factors of preterm birth and consequences of perinatal factors in child health: birth cohorts in two Brazilian cities (BRISA project)

Grant number: 08/53593-0
Support type:Research Projects - Thematic Grants
Duration: May 01, 2009 - November 30, 2013
Field of knowledge:Health Sciences - Collective Health
Principal Investigator:Marco Antonio Barbieri
Grantee:Marco Antonio Barbieri
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Co-Principal Investigators:Heloisa Bettiol ; Maria da Conceição Pereira Saraiva ; Marisa Marcia Mussi ; Ricardo de Carvalho Cavalli ; Virginia Paes Leme Ferriani
Associated scholarship(s):12/10523-8 - Early neonatal mortality in cohort of birth Ribeirão Preto the year 2010, BP.IC
12/02487-1 - Physical activity during pregnancy and adverse birth outcomes in new born - cohort Ribeirão Preto-SP 2010, BP.IC

Abstract

The present study consists of two major subprojects. The first will evaluate new risk factors for preterm birth, such as components of two causality chains, i.e., the neuroendocrine and immune-inflammatory hypotheses. According to the first hypothesis, stress during pregnancy may favor the release of corticotrophin releasing factor (CRH) and the induction of preterm delivery potentiated by CRH gene polymorphisms. According to the second hypothesis, maternal infections may be potentiated by genetic susceptibility, promoting the liberation of inflammatory mediators leading to preterm birth. These hypotheses will be tested in a case-control study within a cohort started during the 5th month of prenatal care in a convenience sample covering 3.000 births in two cities, São Luís (MA) and Ribeirão Preto (SP). This cohort will be re-interviewed at birth and during the 1st year of life. The second subproject will evaluate indicators of perinatal health and their reflexes on preterm and low birth weight rates, comparing them to data for cohorts studied over the last thirty years in the two municipalities. We will also evaluate the impact of preterm birth and other birth conditions on growth, development of insulin resistance, neurological and behavioral alterations, risk factors for allergy and wheezing, and changes in oral health. This evaluation will be performed by interviewing the mothers, by anthropometric evaluation and blood collection for biochemical evaluation and by genetic studies of the children, by the application of allergy skin test and by dental evaluation. This cohort will be started at birth, covering a representative sample of 6000 births in São Luís and 7.500 births in Ribeirão Preto and will be re-evaluated during the first year of Iife. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Before it’s time 

Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LÍGIA MOSCHEN DE PAULA NASCENTE; CARLOS GRANDI; DAVI CASALE ARAGON; VIVIANE CUNHA CARDOSO. Placental measurements and their association with birth weight in a Brazilian cohort. Revista Brasileira de Epidemiologia, v. 23, p. -, 2020.
CALDEIRA-DIAS, MAYARA; MONTENEGRO, MARCELO F.; BETTIOL, HELOISA; BARBIERI, MARCO ANTONIO; CARDOSO, VIVIANE C.; CAVALLI, RICARDO C.; SANDRIM, VALERIA C. Resveratrol improves endothelial cell markers impaired by plasma incubation from women who subsequently develop preeclampsia. HYPERTENSION RESEARCH, v. 42, n. 8, p. 1166-1174, AUG 2019. Web of Science Citations: 0.
MAGNANI, PEDRO SERGIO; BETTIOL, HELOISA; MOURA DA SILVA, ANTONIO AUGUSTO; BARBIERI, MARCO ANTONIO; DE CARVALHO CAVALLI, RICARDO; OLIVEIRA BRITO, LUIZ GUSTAVO. Urinary incontinence between 12 and 24months postpartum: a cross-sectional study nested in a Brazilian cohort from two cities with different socioeconomic characteristics. INTERNATIONAL UROGYNECOLOGY JOURNAL, v. 30, n. 6, p. 1003-1011, JUN 2019. Web of Science Citations: 0.
DE REZENDE, MARCOS GONCALVES; GARCIA-LEAL, CYBELE; SILVA DE SA, MARCOS FELIPE; CAVALLI, RICARDO DE CARVALHO; DEL-BEN, CRISTINA MARTA. Withdrawal of plasma estradiol is associated with increased anxiety reported by women in the first 12 hours after delivery. PSYCHONEUROENDOCRINOLOGY, v. 101, p. 67-71, MAR 2019. Web of Science Citations: 1.
SANDRIM, VALERIA CRISTINA; MACHADO, JACKELINE; BETTIOL, HELOISA; BARBIER, MARCO ANTONIO; CARDOS, VIVIANE CUNHA; PALEI, ANA CAROLINA; CAVALLI, RICARDO CARVALHO. Circulating Tissue Inhibitor of Metalloproteinase-4 levels are not a Predictor of Preeclampsia in the period between 20 and 25 Weeks of Gestation. Revista Brasileira de Ginecologia e Obstetrícia, v. 40, n. 12, p. 757-762, DEC 2018. Web of Science Citations: 0.
VITTI, FERNANDA PINO; GRANDI, CARLOS; CAVALLI, RICARDO DE CARVALHO; FERREIRA SIMOES, VANDA MARIA; LUCENA BATISTA, ROSANGELA FERNANDES; CARDOSO, VIVIANE CUNHA. Association between Caffeine Consumption in Pregnancy and Low Birth Weight and Preterm Birth in the birth Cohort of Ribeirao Preto. Revista Brasileira de Ginecologia e Obstetrícia, v. 40, n. 12, p. 749-756, DEC 2018. Web of Science Citations: 1.
MARQUES, MELINA RODERO; GRANDI, CARLOS; DE PAULA NASCENTE, LIGIA MOSCHEN; CAVALLI, RICARDO CARVALHO; CARDOSO, VIVIANE CUNHA. Placental morphometry in hypertensive disorders of pregnancy and its relationship with birth weight in a Latin American population. PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, v. 13, p. 235-241, JUL 2018. Web of Science Citations: 1.
CUTRIM PROPP LIMA, RAINA JANSEN; LUCENA BATISTA, ROSANGELA FERNANDES; COSTA RIBEIRO, MARIZELIA RODRIGUES; COSTA RIBEIRO, CECILIA CLAUDIA; FERREIRA SIMOES, VANDA MARIA; LIMA NETO, PEDRO MARTINS; MOURA DA SILVA, ANTONIO AUGUSTO; BETTIOL, HELOISA. Prepregnancy body mass index, gestational weight gain, and birth weight in the BRISA cohort. Revista de Saúde Pública, v. 52, p. -, 2018. Web of Science Citations: 3.
SANDRIM, VALERIA C.; CALDEIRA-DIAS, MAYARA; BETTIOL, HELOISA; BARBIERI, MARCO ANTONIO; CARDOSO, VIVIANE CUNHA; CAVALLI, RICARDO CARVALHO. Circulating Heme Oxygenase-1: Not a Predictor of Preeclampsia but Highly Expressed in Pregnant Women Who Subsequently Develop Severe Preeclampsia. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018. Web of Science Citations: 0.
ROSA, CARLOS E.; SOARES, JAIR C.; FIGUEIREDO, FELIPE P.; CAVALLI, RICARDO C.; BARBIERI, MARCO A.; SCHAUFELBERGER, MARISTELA S.; SALMON, CARLOS E. G.; DEL-BEN, CRISTINA M.; SANTOS, ANTONIO C. Glutamatergic and neural dysfunction in postpartum depression using magnetic resonance spectroscopy. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 265, p. 18-25, JUL 30 2017. Web of Science Citations: 13.
SBRANA, MARIANA; GRANDI, CARLOS; BRAZAN, MURILO; JUNQUERA, NATACHA; NASCIMENTO, MARINA STEVAUX; BARBIERI, MARCO ANTONIO; BETTIOL, HELOISA; CARDOSO, VIVIANE CUNHA. Alcohol consumption during pregnancy and perinatal results: a cohort study. São Paulo Medical Journal, v. 134, n. 2, p. 146-152, MAR-APR 2016. Web of Science Citations: 4.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.