| Grant number: | 08/53593-0 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Start date: | May 01, 2009 |
| End date: | November 30, 2013 |
| Field of knowledge: | Health Sciences - Collective Health - Epidemiology |
| Principal Investigator: | Marco Antonio Barbieri |
| Grantee: | Marco Antonio Barbieri |
| Host Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| City of the host institution: | Ribeirão Preto |
| Pesquisadores principais: (Últimos): | Heloisa Bettiol ; Maria da Conceição Pereira Saraiva ; Marisa Marcia Mussi ; Virginia Paes Leme Ferriani |
| Associated scholarship(s): | 12/10523-8 - EARLY NEONATAL MORTALITY IN COHORT OF BIRTH RIBEIRÃO PRETO THE YEAR 2010,
BP.IC 12/02487-1 - PHYSICAL ACTIVITY DURING PREGNANCY AND ADVERSE BIRTH OUTCOMES IN NEW BORN - COHORT RIBEIRÃO PRETO-SP 2010, BP.IC |
Abstract
The present study consists of two major subprojects. The first will evaluate new risk factors for preterm birth, such as components of two causality chains, i.e., the neuroendocrine and immune-inflammatory hypotheses. According to the first hypothesis, stress during pregnancy may favor the release of corticotrophin releasing factor (CRH) and the induction of preterm delivery potentiated by CRH gene polymorphisms. According to the second hypothesis, maternal infections may be potentiated by genetic susceptibility, promoting the liberation of inflammatory mediators leading to preterm birth. These hypotheses will be tested in a case-control study within a cohort started during the 5th month of prenatal care in a convenience sample covering 3.000 births in two cities, São Luís (MA) and Ribeirão Preto (SP). This cohort will be re-interviewed at birth and during the 1st year of life. The second subproject will evaluate indicators of perinatal health and their reflexes on preterm and low birth weight rates, comparing them to data for cohorts studied over the last thirty years in the two municipalities. We will also evaluate the impact of preterm birth and other birth conditions on growth, development of insulin resistance, neurological and behavioral alterations, risk factors for allergy and wheezing, and changes in oral health. This evaluation will be performed by interviewing the mothers, by anthropometric evaluation and blood collection for biochemical evaluation and by genetic studies of the children, by the application of allergy skin test and by dental evaluation. This cohort will be started at birth, covering a representative sample of 6000 births in São Luís and 7.500 births in Ribeirão Preto and will be re-evaluated during the first year of Iife. (AU)
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