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Etiological factors of preterm birth and consequences of perinatal factors in child health: birth cohorts in two Brazilian cities (BRISA project)

Abstract

The present study consists of two major subprojects. The first will evaluate new risk factors for preterm birth, such as components of two causality chains, i.e., the neuroendocrine and immune-inflammatory hypotheses. According to the first hypothesis, stress during pregnancy may favor the release of corticotrophin releasing factor (CRH) and the induction of preterm delivery potentiated by CRH gene polymorphisms. According to the second hypothesis, maternal infections may be potentiated by genetic susceptibility, promoting the liberation of inflammatory mediators leading to preterm birth. These hypotheses will be tested in a case-control study within a cohort started during the 5th month of prenatal care in a convenience sample covering 3.000 births in two cities, São Luís (MA) and Ribeirão Preto (SP). This cohort will be re-interviewed at birth and during the 1st year of life. The second subproject will evaluate indicators of perinatal health and their reflexes on preterm and low birth weight rates, comparing them to data for cohorts studied over the last thirty years in the two municipalities. We will also evaluate the impact of preterm birth and other birth conditions on growth, development of insulin resistance, neurological and behavioral alterations, risk factors for allergy and wheezing, and changes in oral health. This evaluation will be performed by interviewing the mothers, by anthropometric evaluation and blood collection for biochemical evaluation and by genetic studies of the children, by the application of allergy skin test and by dental evaluation. This cohort will be started at birth, covering a representative sample of 6000 births in São Luís and 7.500 births in Ribeirão Preto and will be re-evaluated during the first year of Iife. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Un batallón de nacimientos precoces 
Early-term births on the rise 
Before it’s time 
Antes de tiempo 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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VEICULO: TITULO (DATA)

Scientific publications (31)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARQUES, MELINA RODERO; GRANDI, CARLOS; DE PAULA NASCENTE, LIGIA MOSCHEN; CAVALLI, RICARDO CARVALHO; CARDOSO, VIVIANE CUNHA. Placental morphometry in hypertensive disorders of pregnancy and its relationship with birth weight in a Latin American population. PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, v. 13, p. 235-241, . (08/53593-0)
MÔNICA ARAUJO BATALHA; ANA KARINA TEIXEIRA DA CUNHA FRANÇA; SUELI ISMAEL OLIVEIRA DA CONCEIÇÃO; ALCIONE MIRANDA DOS SANTOS; FRANCELENA DE SOUSA SILVA; LUANA LOPES PADILHA; ANTÔNIO AUGUSTO MOURA DA SILVA. Consumo de alimentos processados e ultraprocessados e fatores associados em crianças entre 13 e 35 meses de idade. Cadernos de Saúde Pública, v. 33, n. 11, . (08/53593-0)
SANDRIM, VALERIA C.; CALDEIRA-DIAS, MAYARA; BETTIOL, HELOISA; BARBIERI, MARCO ANTONIO; CARDOSO, VIVIANE CUNHA; CAVALLI, RICARDO CARVALHO. Circulating Heme Oxygenase-1: Not a Predictor of Preeclampsia but Highly Expressed in Pregnant Women Who Subsequently Develop Severe Preeclampsia. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, . (08/53593-0, 15/20461-8)
RAINA JANSEN CUTRIM PROPP LIMA; ROSÂNGELA FERNANDES LUCENA BATISTA; MARIZÉLIA RODRIGUES COSTA RIBEIRO; CECÍLIA CLÁUDIA COSTA RIBEIRO; VANDA MARIA FERREIRA SIMÕES; PEDRO MARTINS LIMA NETO; ANTÔNIO AUGUSTO MOURA DA SILVA; HELOISA BETTIOL. Prepregnancy body mass index, gestational weight gain, and birth weight in the BRISA cohort. Revista de Saúde Pública, v. 52, . (08/53593-0)
DE REZENDE, MARCOS GONCALVES; GARCIA-LEAL, CYBELE; SILVA DE SA, MARCOS FELIPE; CAVALLI, RICARDO DE CARVALHO; DEL-BEN, CRISTINA MARTA. Withdrawal of plasma estradiol is associated with increased anxiety reported by women in the first 12 hours after delivery. PSYCHONEUROENDOCRINOLOGY, v. 101, p. 67-71, . (08/53593-0)
FRANCELENA DE SOUSA SILVA; REJANE CHRISTINE DE SOUSA QUEIROZ; MARIA DOS REMÉDIOS FREITAS CARVALHO BRANCO; VANDA MARIA FERREIRA SIMÕES; YONNA COSTA BARBOSA; MARCELO AUGUSTO FERRAZ RUAS DO AMARAL RODRIGUES; MARCO ANTONIO BARBIERI; HELOÍSA BETTIOL; MARIA DA CONCEIÇÃO PEREIRA SARAIVA; LUIZ GUILHERME SCORZAFAVE; et al. Programa bolsa família e vacinação infantil incompleta em duas coortes brasileiras. Revista de Saúde Pública, v. 54, . (08/53593-0)
CALDEIRA-DIAS, MAYARA; MONTENEGRO, MARCELO F.; BETTIOL, HELOISA; BARBIERI, MARCO ANTONIO; CARDOSO, VIVIANE C.; CAVALLI, RICARDO C.; SANDRIM, VALERIA C.. Resveratrol improves endothelial cell markers impaired by plasma incubation from women who subsequently develop preeclampsia. HYPERTENSION RESEARCH, v. 42, n. 8, p. 1166-1174, . (08/53593-0, 15/20461-8)
CRUZ DA SILVA QUEIROZ, RAFAELLE CRISTINA; DE SOUSA QUEIROZ, REJANE CHRISTINE; HERNANDES ROCHA, THIAGO AUGUSTO; SILVA, FRANCELENA DE SOUSA; DOS SANTOS, IZANI GONCALVES; DA SILVA, ISAIAS PEREIRA; DA SILVA, NUBIA CRISTINA; BARBIERI, MARCO ANTONIO; PEREIRA SARAIVA, MARIA DA CONCEICAO; MOURA DA SILVA, ANTONIO AUGUSTO. Serviços de vacinação e cobertura vacinal incompleta em crianças: uma análise espacial comparativa das coortes BRISA, São Luís (Maranhão) e Ribeirão Preto (São Paulo), Brasil. Cadernos de Saúde Pública, v. 37, n. 6, . (08/53593-0)
K.S.D. TROMBE; L.S. RODRIGUES; L.M.P. NASCENTE; V.M.F. SIMÕES; R.F.L. BATISTA; R.C. CAVALLI; C. GRANDI; V.C. CARDOSO. Is birth weight associated with pregestational maternal BMI? BRISA Cohort, Ribeirão Preto, Brazil. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, . (08/53593-0)
I.C. RODRIGUES; C. GRANDI; V.M.F. SIMÕES; R.F.L. BATISTA; L.S. RODRIGUES; V.C. CARDOSO. Metabolic profile during pregnancy in BRISA birth cohorts of Ribeirão Preto and São Luís, Brazil. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, . (08/53593-0)
F.M.M. BERNARDO; E.C.A. VEIGA; S.M. QUINTANA; F.J.A. CAMAYO; R.F.L. BATISTA; M.T.S.S.B. ALVES; H. BETTIOL; M.A. BARBIERI; V.C. CARDOSO; R.C. CAVALLI. Association of genitourinary infections and cervical length with preterm childbirth. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, . (08/53593-0)
M.E.A. NEGRÃO; P.R.H. ROCHA; M.C.P. SARAIVA; M.A. BARBIERI; V.M.F. SIMÕES; R.F.L. BATISTA; A.A. FERRARO; H. BETTIOL. Association between tobacco and/or alcohol consumption during pregnancy and infant development: BRISA Cohort. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, p. 10252-0, . (08/53593-0)
LÍGIA MOSCHEN DE PAULA NASCENTE; CARLOS GRANDI; DAVI CASALE ARAGON; VIVIANE CUNHA CARDOSO. Medidas placentárias e sua associação com o peso ao nascer em uma coorte brasileira. Revista Brasileira de Epidemiologia, v. 23, . (08/53593-0)
ROCHA, PAULO RICARDO H.; SARAIVA, MARIA DA C. P.; BARBIERI, MARCO A.; FERRARO, ALEXANDRE A.; BETTIOL, HELOISA. Association of preterm birth and intrauterine growth restriction with childhood motor development: Brisa cohort, Brazil. INFANT BEHAVIOR & DEVELOPMENT, v. 58, . (08/53593-0)
L.A.B. MARTINS; E.C.A. VEIGA; C.C.C. RIBEIRO; V.M.F. SIMÕES; V.C. CARDOSO; H. BETTIOL; M.A. BARBIERI; R.C. CAVALLI. Uterine vascular resistance and other maternal factors associated with the risk of developing hypertension during pregnancy. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, . (08/53593-0)
ANA GIMÉNEZ; ADRIANA OLIVEIRA DIAS DE SOUSA MORAIS; LUIS DE SALDAMANDO; VANDA MARIA FERREIRA SIMÕES; MARÍA ROSA CURUTCHET; LÍVIA DOS SANTOS RODRIGUES; GASTÓN ARES; ROSÂNGELA FERNANDES LUCENA BATISTA; ZENI CARVALHO LAMY; CAROLINA ABREU DE CARVALHO; et al. Desenho das embalagens e perfil nutricional de alimentos dirigidos ao público infantil em supermercados em Montevidéu, Uruguai. Cadernos de Saúde Pública, v. 33, n. 6, . (08/53593-0)
VIANA-MATTIOLI, SARAH; NUNES, PRISCILA; CAVALLI, RICARDO; SANDRIM, VALERIA. Analysis of SIRT1 Expression in Plasma and in an In Vitro Model of Preeclampsia. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2020, . (08/53593-0, 19/06118-0, 15/20461-8)
T. TROVÃO; M.C.V. CAVALCANTE; M.C. RODRIGUES; A.A. FERRARO; H. BETTIOL; M.C.P. SARAIVA; Z.C. LAMY; F. LAMY-FILHO. Determinants of the introduction of early complementary feeding before and after the third month of life: a multinomial analysis. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, . (08/53593-0)
BARBOSA, RAPHAEL; SOARES BRITTO ALVES, MARIA TERESA SEABRA; NATHASJE, IAN; CHAGAS, DEYSIANNE; SIMOES, VANDA FERREIRA; SILVA, LEONARDO. Factors Associated with Inadequate Birth Intervals in the BRISA Birth Cohort, Brazil. Revista Brasileira de Ginecologia e Obstetrícia, v. 42, n. 2, p. 67-73, . (08/53593-0)
MAGNANI, PEDRO SERGIO; BETTIOL, HELOISA; MOURA DA SILVA, ANTONIO AUGUSTO; BARBIERI, MARCO ANTONIO; DE CARVALHO CAVALLI, RICARDO; OLIVEIRA BRITO, LUIZ GUSTAVO. Urinary incontinence between 12 and 24months postpartum: a cross-sectional study nested in a Brazilian cohort from two cities with different socioeconomic characteristics. INTERNATIONAL UROGYNECOLOGY JOURNAL, v. 30, n. 6, p. 1003-1011, . (08/53593-0)
M.C.V. CAVALCANTE; Z.C. LAMY; A.K.T.C. FRANÇA; M.U.L. PEREIRA; A.A. FERRARO; M.A. BARBIERI; F. LAMY-FILHO. Psychological distress and mother-child relationship: influence of life context on a population sample (BRISA) through the use of directed acyclic graphs (DAG). Brazilian Journal of Medical and Biological Research, v. 54, n. 1, . (08/53593-0)
ADRIANA OLIVEIRA DIAS DE SOUSA MORAIS; VANDA MARIA FERREIRA SIMÕES; LÍVIA DOS SANTOS RODRIGUES; ROSÂNGELA FERNANDES LUCENA BATISTA; ZENI CARVALHO LAMY; CAROLINA ABREU DE CARVALHO; ANTÔNIO AUGUSTO MOURA DA SILVA; MARIZÉLIA RODRIGUES COSTA RIBEIRO. Sintomas depressivos e de ansiedade maternos e prejuízos na relação mãe/filho em uma coorte pré-natal: uma abordagem com modelagem de equações estruturais. Cadernos de Saúde Pública, v. 33, n. 6, . (08/53593-0)
ROSA, CARLOS E.; SOARES, JAIR C.; FIGUEIREDO, FELIPE P.; CAVALLI, RICARDO C.; BARBIERI, MARCO A.; SCHAUFELBERGER, MARISTELA S.; SALMON, CARLOS E. G.; DEL-BEN, CRISTINA M.; SANTOS, ANTONIO C.. Glutamatergic and neural dysfunction in postpartum depression using magnetic resonance spectroscopy. PSYCHIATRY RESEARCH-NEUROIMAGING, v. 265, p. 18-25, . (08/53593-0)
NÁDIA CARENINA NUNES CAVALCANTE; VANDA MARIA FERREIRA SIMÕES; MARIZÉLIA RODRIGUES COSTA RIBEIRO; FERNANDO LAMY-FILHO; MARCO ANTONIO BARBIERI; HELOISA BETTIOL; ANTÔNIO AUGUSTO MOURA DA SILVA. Fatores socioeconômicos maternos e eventos perinatais adversos em duas coortes de nascimento, 1997/98 e 2010, em São Luís, Brasil. Revista Brasileira de Epidemiologia, v. 20, n. 4, p. 676-687, . (08/53593-0)
OLIVEIRA SOUZA, MARILIA CRISTINA; SARAIVA, MARIA CONCEICAO PEREIRA; HONDA, MASATO; BARBIERI, MARCO ANTONIO; BETTIOL, HELOISA; BARBOSA, FERNANDO; KANNAN, KURUNTHACHALAM. Exposure to per- and polyfluorinated alkyl substances in pregnant Brazilian women and its association with fetal growth. Environmental Research, v. 187, . (18/24069-3, 16/23372-9, 15/19665-8, 08/53593-0)
JOÃO ROBERTO R. PIMENTA; CARLOS GRANDI; DAVI C. ARAGON; VIVIANE CUNHA CARDOSO. Comparação de peso, comprimento e perímetro cefálico ao nascer entre Coorte BRISA-RP e Intergrowth-21st,. Jornal de Pediatria, v. 96, n. 4, p. 511-519, . (08/53593-0)
GRANDI, CARLOS; RODRIGUES, LIVIA DOS S.; ARAGON, DAVI C.; CARMONA, FABIO; CARDOSO, VIVIANE C.. Weight/length ratio references and newborn body composition estimation at birth from a Brazilian cohort. Jornal de Pediatria, v. 97, n. 6, p. 610-616, . (08/53593-0)
CUNHA, GKP; BASTOS, L. B.; FREITAS, S. F.; CAVALLI, R. C.; QUINTANA, S. M.. Genital mycoplasma infection and spontaneous preterm birth outcome: a prospective cohort study. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, v. 129, n. 2, . (08/53593-0)
J.M.A. BARBOSA; A.A.M. DA SILVA; G. KAC; V.M.F. SIMÕES; H. BETTIOL; R.C. CAVALLI; M.A. BARBIERI; C.C.C. RIBEIRO. Is soft drink consumption associated with gestational hypertension? Results from the BRISA cohort. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, . (08/53593-0)
J.M. FONSECA; A.A.M. SILVA; P.R.H. ROCHA; R.L.F. BATISTA; E.B.A.F. THOMAZ; F. LAMY-FILHO; M.A. BARBIERI; H. BETTIOL. Racial inequality in perinatal outcomes in two Brazilian birth cohorts. Brazilian Journal of Medical and Biological Research, v. 54, n. 1, . (08/53593-0)
LUIZON, MARCELO R.; CONCEICAO, IZABELA M. C. A.; VIANA-MATTIOLI, SARAH; CALDEIRA-DIAS, MAYARA; CAVALLI, RICARDO C.; SANDRIM, VALERIA C.. Circulating MicroRNAs in the Second Trimester From Pregnant Women Who Subsequently Developed Preeclampsia: Potential Candidates as Predictive Biomarkers and Pathway Analysis for Target Genes of miR-204-5p. FRONTIERS IN PHYSIOLOGY, v. 12, . (15/20461-8, 08/53593-0)

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