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Clinical, cellular and molecular alterations in hemoglobinopathies and other hereditary hemolytic anemias

Grant number: 08/57441-0
Support type:Research Projects - Thematic Grants
Duration: June 01, 2009 - May 31, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Fernando Ferreira Costa
Grantee:Fernando Ferreira Costa
Home Institution: Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Co-Principal Investigators:Carla Fernanda Franco Penteado ; Maria de Fatima Sonati ; Mônica Barbosa de Melo ; Nicola Amanda Conran Zorzetto
Associated grant(s):12/50582-3 - Scientific cooperation for the study of haemoglobinopathies: clinical, cellular and molecular alterations, AP.R
10/51459-5 - Scientific cooperation for the study of clinical, cellular and molecular alterations in the haemoglobinopathies and the understanding of the regulation of fetal haemoglobin, AP.R
Associated scholarship(s):12/07869-0 - Investigation of the role of YY1 and PAX1 transcription factors in the molecular mechanisms involved in the Brazilian type of hereditary persistence of fetal hemoglobin, BP.DR
12/06438-5 - High-density microarray technique in the assessment of stroke susceptibility in patients with sickle cell anemia, BP.DR
11/17553-7 - Expression of the inflammatory cytokine light in platelets of Sickle Cell disease patients: evaluation of activation of leukocytes and endothelial cells, BP.DD
+ associated scholarships 11/50959-7 - Standardization of transgenic sickle mice bone marrow transplantation, inflammatory induction and assessment of in vivo platelets role in vaso-occlusion, BP.PD
11/02380-0 - Evaluation of the effects of inhibition of the Rho/Rho-kinase in the eosinophils adhesion in patients with sickle cell anemia and in asthma experimental model in sickle mice, BP.DR
11/07681-8 - Standardization of automatic method for the functional study of human hemoglobin variants, BP.IC
09/15219-2 - Biochemical and genetical analysis of cell adhesion and vascular growth pathways: association with sickle cell retinopathy development, BP.MS
09/18248-3 - Correlation between function and structure of structural variants of the human hemoglobin, BP.DR
09/54279-0 - Interactions between platelets from sickle cell anemia patients and human umbilical vein endothelial cells (HUVEC): in vitro evaluation of platelets adhesion and their effects on the endothelial activation, BP.DR
09/16334-0 - Aspects of angiogenesis in sickle cell anemia, BP.PD - associated scholarships
Articles published in Agência FAPESP about the research grant
Viagra could help treat complications associated with sickle cell anemia 
Brazilian drug shows good results against sickle cell anemia 
Research tests therapy for acute stages of sickle cell anemia  

Scientific publications (25)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CRUZ, PEDRO R. S.; ANANINA, GALINA; GIL-DA-SILVA-LOPES, VERA LUCIA; SIMIONI, MILENA; MENAA, FARID; BEZERRA, MARCOS A. C.; DOMINGOS, IGOR F.; ARAUJO, ADERSON S.; PELLEGRINO, RENATA; HAKONARSON, HAKON; COSTA, FERNANDO F.; DE MELO, MONICA BARBOSA. Genetic comparison of sickle cell anaemia cohorts from Brazil and the United States reveals high levels of divergence. SCIENTIFIC REPORTS, v. 9, JUL 26 2019. Web of Science Citations: 0.
LANARO, CAROLINA; FRANCO-PENTEADO, CARLA F.; SILVA, FABIO H.; FERTRIN, KLEBER Y.; DOS SANTOS, JEAN LEANDRO; WADE, MARLENE; YERIGENAHALLY, SHOBHA; DE MELO, THAIS R.; CHIN, CHUNG MAN; KUTLAR, ABDULLAH; MEILER, STEFFEN E.; COSTA, FERNANDO FERREIRA. A thalidomide-hydroxyurea hybrid increases HbF production in sickle cell mice and reduces the release of proinflammatory cytokines in cultured monocytes. Experimental Hematology, v. 58, p. 35-38, FEB 2018. Web of Science Citations: 2.
GARRIDO, VANESSA TONIN; SONZOGNI, LAURA; MTATIRO, SIANA NKYA; COSTA, FERNANDO F.; CONRAN, NICOLA; THEIN, SWEE LAY. Association of plasma CD4OL with acute chest syndrome in sickle cell anemia. CYTOKINE, v. 97, p. 104-107, SEP 2017. Web of Science Citations: 7.
BAPTISTA, LETICIA C.; COSTA, MARIA LAURA; FERREIRA, REGIANE; ALBUQUERQUE, DULCINEIA M.; LANARO, CAROLINA; FERTRIN, KLEBER Y.; SURITA, FERNANDA G.; PARPINELLI, MARY A.; COSTA, FERNANDO F.; DE MELO, MONICA BARBOSA. Abnormal expression of inflammatory genes in placentas of women with sickle cell anemia and sickle hemoglobin C disease. ANNALS OF HEMATOLOGY, v. 95, n. 11, p. 1859-1867, NOV 2016. Web of Science Citations: 3.
LEONARDO, DANIELA P.; ALBUQUERQUE, DULCINELA M.; LANARO, CAROLINA; BAPTISTA, LETICIA C.; CECATTI, JOSE G.; SURITA, FERNANDA G.; PARPINELLI, MARY A.; COSTA, FERNANDO F.; FRANCO-PENTEADO, CARLA F.; FERTRIN, KLEBER Y.; COSTA, MARIA LAURA. Association of Nitric Oxide Synthase and Matrix Metalloprotease Single Nucleotide Polymorphisms with Preeclampsia and Its Complications. PLoS One, v. 10, n. 8 AUG 28 2015. Web of Science Citations: 13.
CLAUDINO, MARIO ANGELO; SILVEIRA LEIRIA, LUIZ OSORIO; DA SILVA, FABIO HENRIQUE; ALEXANDRE, EDUARDO COSTA; RENNO, ANDRE; MONICA, FABIOLA ZAKIA; DE NUCCI, GILBERTO; FERTRIN, KLEBER YOTSUMOTO; ANTUNES, EDSON; COSTA, FERNANDO FERREIRA; FRANCO-PENTEADO, CARLA FERNANDA. Urinary Bladder Dysfunction in Transgenic Sickle Cell Disease Mice. PLoS One, v. 10, n. 8 AUG 4 2015. Web of Science Citations: 4.
LOPES, FLAVIA C. M.; TRAINA, FABIOLA; ALMEIDA, CAMILA B.; LEONARDO, FLAVIA C.; FRANCO-PENTEADO, CARLA F.; GARRIDO, VANESSA T.; COLELLA, MARINA P.; SOARES, RAQUEL; OLALLA-SAAD, SARA T.; COSTA, FERNANDO F.; CONRAN, NICOLA. Key endothelial cell angiogenic mechanisms are stimulated by the circulating milieu in sickle cell disease and attenuated by hydroxyurea. Haematologica, v. 100, n. 6, p. 730-739, JUN 2015. Web of Science Citations: 15.
THALES ALLYRIO ARAÚJO DE MEDEIROS FERNANDES; TEREZA MARIA DANTAS DE MEDEIROS; JAYRA JULIANA PAIVA ALVES; CHRISTIANE MEDEIROS BEZERRA; JOSÉ VERÍSSIMO FERNANDES; ÉDVIS SANTOS SOARES SERAfiM; MARIA ZÉLIA FERNANDES; MARIA DE FATIMA SONATI. Socioeconomic and demographic characteristics of sickle cell disease patients from a low-income region of northeastern Brazil. Revista Brasileira de Hematologia e Hemoterapia, v. 37, n. 3, p. 172-177, Jun. 2015.
CRUZ, P. R. S.; LIRA, R. P. C.; PEREIRA FILHO, S. A. C.; SOUZA, B. B.; MITSUUSHI, F. N.; MENAA, F.; FERTRIN, K. Y.; VASCONCELLOS, J. P. C.; CONRAN, N.; COSTA, F. F.; MELO, M. B. Increased circulating PEDF and low sICAM-1 are associated with sickle cell retinopathy. BLOOD CELLS MOLECULES AND DISEASES, v. 54, n. 1, p. 33-37, JAN 2015. Web of Science Citations: 8.
ELZA MIYUKI KIMURA; DENISE MADUREIRA OLIVEIRA; SUSAN ELISABETH JORGE; DANIELA MARIA RIBEIRO; TÂNIA REGINA ZACCARIOTTO; MAGNUN NUELDO NUNES SANTOS; VANESSA ALMEIDA; DULCINÉIA MARTINS ALBUQUERQUE; FERNANDO FERREIRA COSTA; MARIA DE FÁTIMA SONATI. Investigating alpha-globin structural variants: a retrospective review of 135,000 Brazilian individuals. Revista Brasileira de Hematologia e Hemoterapia, v. 37, n. 2, p. -, Abr. 2015.
DOS SANTOS, ALISSON F.; ALMEIDA, CAMILA B.; BRUGNEROTTO, ANA F.; ROVERSI, FERNANDA M.; PALLIS, FLAVIA R.; FRANCO-PENTEADO, CARLA F.; LANARO, CAROLINA; ALBUQUERQUE, DULCINEIA M.; LEONARDO, FLAVIA C.; COSTA, FERNANDO F.; CONRAN, NICOLA. Reduced plasma angiotensin II levels are reversed by hydroxyurea treatment in mice with sickle cell disease. Life Sciences, v. 117, n. 1, p. 7-12, NOV 4 2014. Web of Science Citations: 3.
MASCIA LOPES, FLAVIA CRISTINE; FERREIRA, REGIANE; ALBUQUERQUE, DULCINEIA MARTINS; ANTONIELLIS SILVEIRA, ANGELICA A.; COSTA, RAQUEL; SOARES, RAQUEL; COSTA, FERNANDO FERREIRA; CONRAN, NICOLA. In vitro and in vivo anti-angiogenic effects of hydroxyurea. MICROVASCULAR RESEARCH, v. 94, p. 106-113, JUL 2014. Web of Science Citations: 15.
FERTRIN, KLEBER YOTSUMOTO; LANARO, CAROLINA; FRANCO-PENTEADO, CARLA FERNANDA; DE ALBUQUERQUE, DULCINEIA MARTINS; BANDEIRA DE MELLO, MARIANA REZENDE; PALLIS, FLAVIA RUBIA; CAVALCANTI BEZERRA, MARCOS ANDRE; DOMINGUES HATZLHOFER, BETANIA LUCENA; OLBINA, GORDANA; OLALLA SAAD, SARA TEREZINHA; ARAUJO, ADERSON DA SILVA; WESTERMAN, MARK; COSTA, FERNANDO FERREIRA. Erythropoiesis-driven regulation of hepcidin in human red cell disorders is better reflected through concentrations of soluble transferrin receptor rather than growth differentiation factor 15. American Journal of Hematology, v. 89, n. 4, p. 385-390, APR 2014. Web of Science Citations: 13.
PROENCA-FERREIRA, RENATA; BRUGNEROTTO, ANA FLAVIA; GARRIDO, VANESSA TONIN; DOMINICAL, VENINA MARCELA; VITAL, DAIANA MORELLI; REIS RIBEIRO, MARILENE DE FATIMA; DOS SANTOS, MELISSA ERCOLIN; TRAINA, FABIOLA; OLALLA-SAAD, SARA T.; COSTA, FERNANDO FERREIRA; CONRAN, NICOLA. Endothelial Activation by Platelets from Sickle Cell Anemia Patients. PLoS One, v. 9, n. 2 FEB 13 2014. Web of Science Citations: 18.
LOPES, MARIANA PEZZUTE; NUNES SANTOS, MAGNUN NUELDO; FABER, ELIEL WAGNER; CAVALCANTI BEZERRA, MARCOS ANDRE; DOMINGUES HATZLHOFER, BETANIA LUCENA; ALBUQUERQUE, DULCINEIA MARTINS; ZACCARIOTTO, TANIA REGINA; RIBEIRO, DANIELA MARIA; ARAUJO, ADERSON DA SILVA; COSTA, FERNANDO FERREIRA; SONATI, MARIA DE FATIMA. The CCR5 Delta 32 Polymorphism in Brazilian Patients with Sickle Cell Disease. DISEASE MARKERS, 2014. Web of Science Citations: 3.
DA LUZ, J.; LOPEZ, P.; KIMURA, E. M.; ALBUQUERQUE, D. M.; COSTA, F. F.; SANS, M.; SONATI, M. F. A new beta(0)-thalassemia frameshift mutation [beta 48 (-T)] in a Uruguayan family. INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, v. 35, n. 1, p. 111-114, FEB 2013. Web of Science Citations: 0.
DA LUZ, JULIO; AVILA, AMALIA; ICASURIAGA, SANDRA; GONGORA, MARIA; CASTILLO, LUIS; SERRON, ALEJANDRA; KIMURA, ELZA MIYUKI; COSTA, FERNANDO FERREIRA; SANS, MONICA; SONATI, MARIA DE FATIMA. Frequency and spectrum of hemoglobinopathy mutations in a Uruguayan pediatric population. GENETICS AND MOLECULAR BIOLOGY, v. 36, n. 3, p. 316-322, 2013. Web of Science Citations: 5.
GIL, GISLENE P.; ANANINA, GALINA; OLIVEIRA, MARIANA B.; COSTA, FERNANDO F.; SILVA, MARCIO J.; SANTOS, MAGNUN N. N.; BEZERRA, MARCOS A. C.; HATZLHOFER, BETANIA L. D.; ARAUJO, ADERSON S.; MELO, MONICA B. POLYMORPHISM IN THE HMOX1 GENE IS ASSOCIATED WITH HIGH LEVELS OF FETAL HEMOGLOBIN IN BRAZILIAN PATIENTS WITH SICKLE CELL ANEMIA. HEMOGLOBIN, v. 37, n. 4, p. 315-324, 2013. Web of Science Citations: 4.
JORGE, SUSAN E. D. C.; PETRUK, ARIEL A.; KIMURA, ELZA M.; OLIVEIRA, DENISE M.; CAIRE, LUCAS; SUEMASU, CINTIA N.; SILVEIRA, PAULO A. A.; ALBUQUERQUE, DULCINEIA M.; COSTA, FERNANDO F.; SKAF, MUNIR S.; MARTINEZ, LEANDRO; SONATI, MARIA DE FATIMA. Hb S-Sao Paulo: A new sickling hemoglobin with stable polymers and decreased oxygen affinity. Archives of Biochemistry and Biophysics, v. 519, n. 1, p. 23-31, MAR 1 2012. Web of Science Citations: 2.
DE MEDEIROS ALCOFORADO, GUSTAVO HENRIQUE; BEZERRA, CHRISTIANE MEDEIROS; ARAUJO MOURA LEMOS, TELMA MARIA; DE OLIVEIRA, DENISE MADUREIRA; KIMURA, ELZA MIYUKI; COSTA, FERNANDO FERREIRA; SONATI, MARIA DE FATIMA; DANTAS DE MEDEIROS, TEREZA MARIA. Prevalence of alpha-thalassemia 3.7 kb deletion in the adult population of Rio Grande do Norte, Brazil. GENETICS AND MOLECULAR BIOLOGY, v. 35, n. 3, p. 594-598, 2012. Web of Science Citations: 5.
ZACCARIOTTO, T. R.; LANARO, C.; ALBUQUERQUE, D. M.; SANTOS, M. N. N.; BEZERRA, M. A. C.; CUNHA, F. G. P.; LORAND-METZE, I.; ARAUJO, A. S.; COSTA, F. F.; SONATI, M. F. Expression profiles of phosphatidylinositol phosphate kinase genes during normal human in vitro erythropoiesis. Genetics and Molecular Research, v. 11, n. 4, p. 3861-3868, 2012. Web of Science Citations: 2.
NUNES SANTOS, MAGNUN NUELDO; CAVALCANTI BEZERRA, MARCOS ANDRE; TAVARES BORGES DOMINGUES, BETANIA LUCENA; ZACCARIOTTO, TANIA REGINA; OLIVEIRA, DENISE MADUREIRA; COSTA, FERNANDO FERREIRA; ARAUJO, ADERSON DA SILVA; SONATI, MARIA DE FATIMA. Haptoglobin Genotypes in Sickle-Cell Disease. GENETIC TESTING AND MOLECULAR BIOMARKERS, v. 15, n. 10, p. 709-713, OCT 2011. Web of Science Citations: 1.
SUEMASU, C. N.; KIMURA, E. M.; OLIVEIRA, D. M.; BEZERRA, M. A. C.; ARAUJO, A. S.; COSTA, F. F.; SONATI, M. F. Characterization of alpha thalassemic genotypes by multiplex ligation-dependent probe amplification in the Brazilian population. Brazilian Journal of Medical and Biological Research, v. 44, n. 1, p. 16-22, JAN 2011. Web of Science Citations: 6.
KITAYAMA CABRAL, CYNTHIA HATSUE; SOARES SERAFIM, EDVIS SANTOS; DANTAS BEZERRA DE MEDEIROS, WALESKA RAYANE; ARAUJO DE MEDEIROS FERNANDES, THALES ALLYRIO; KIMURA, ELZA MIYUKI; COSTA, FERNANDO FERREIRA; SONATI, MARIA DE FATIMA; MORETTI REBECCHI, IVANISE MARINA; DANTAS DE MEDEIROS, TEREZA MARIA. Determination of beta(S) haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil. GENETICS AND MOLECULAR BIOLOGY, v. 34, n. 3, p. 421-424, 2011. Web of Science Citations: 4.
LUNA DA SILVEIRA, ZAMA MESSALA; BARBOSA, MARIA DAS VITORIAS; ARAUJO DE MEDEIROS FERNANDES, THALES ALLYRIO; KIMURA, ELZA MIYUKI; COSTA, FERNANDO FERREIRA; SONATI, MARIA DE FATIMA; MORETTI REBECCHI, IVANISE MARINA; DANTAS DE MEDEIROS, TEREZA MARIA. Characterization of beta-thalassemia mutations in patients from the state of Rio Grande do Norte, Brazil. GENETICS AND MOLECULAR BIOLOGY, v. 34, n. 3, p. 425-428, 2011. Web of Science Citations: 6.

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