Lipids metabolism-related gene polymorphisms, diseases, laboratory exams in a Brazilian elderly cohort from districtal region of São Paulo

• Grant number: 06/07240-3
• Support Opportunities: Regular Research Grants
• Duration: April 01, 2007 - March 31, 2009
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Marilia de Arruda Cardoso Smith
• Grantee: Marilia de Arruda Cardoso Smith
• Host Institution: Departamento de Morfologia. Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Apolipoproteins have na important role in lipid metabolism. Some genetic polymorphisms have been associated with age-related conditions, such as cardiovascular diseases and atherosclerosis. Transcription factors such as peroxysome proliferator-activated receptor (PPAR) have a marked effect on lipids metabolism. APO A-V gene is a target for PPAR in reducing TG levels. Cardiovascular diseases are the major mortality cause in adult population (32%). The aim of our research is to investigate the association of genes cluster APOA-I/CIII/AIV/AV polymorphisms as well as PPAR polymorphisms with age-related conditions and with many laboratory exams in a Brazilian elderly cohort composed by 350 subjects. This genetics-epidemiology approach is original for Brazilian population. The following age-related conditions have been investigated: myocardial infarction and/or coronary heart disease, cerebrovascular disease and/or transitory ischaemic attack, hypertension, obesity, type 2 diabetes, low cognitive level (dementia), depression and neoplasia. The following laboratory exams have been studied: lipid and fractions, albumin, creatinin, urea, glycated hemoglobin and fasting glucose. Gene polymorphisms will be investigated by PCR-RFLP. Genes frequencies will be determined in this cohor and Hardy-Weinberg equilibrium will be tested. The identification of genetic risk factors may contribute to diagnosis, prognosis, prevention and treatment for age-related diseases in Brazilian elderly population as well as to a better understanding of the physiopathological role of these polymorphisms. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RASMUSSEN, LUCAS; DELABIO, ROGER; HORIGUCHI, LIE; MIZUMOTO, IGOR; TERAZAKI, CARLOS-RENATO; MAZZOTTI, DIEGO; BERTOLUCCI, PAULO-HENRIQUE; PINHEL, MARCELA-AUGUSTA; SOUZA, DOROTEIA; KRIEGER, HENRIQUE; et al. Association Between Interleukin 6 Gene Haplotype and Alzheimer's Disease: A Brazilian Case-Control Study. JOURNAL OF ALZHEIMER'S DISEASE, v. 36, n. 4, p. 733-738, 2013. (04/15273-3, 09/15857-9, 06/07240-3)

MARQUES PAYAO, SPENCER LUIZ; GONCALVES, GISELA MORAES; DE LABIO, ROGER WILLIAM; HORIGUCHI, LIE; MIZUMOTO, IGOR; RASMUSSEN, LUCAS TREVIZANI; DE SOUZA PINHEL, MARCELA AUGUSTA; SILVA SOUZA, DOROTEIA ROSSI; BECHARA, MARCELO DIB; CHEN, ELIZABETH; et al. Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease. Journal of Neuroimmunology, v. 247, n. 1-2, p. 59-62, JUN 15 2012. (04/15273-3, 09/15857-9, 06/07240-3)