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Lipids metabolism-related gene polymorphisms, diseases, laboratory exams in a Brazilian elderly cohort from districtal region of São Paulo


Apolipoproteins have na important role in lipid metabolism. Some genetic polymorphisms have been associated with age-related conditions, such as cardiovascular diseases and atherosclerosis. Transcription factors such as peroxysome proliferator-activated receptor (PPAR) have a marked effect on lipids metabolism. APO A-V gene is a target for PPAR in reducing TG levels. Cardiovascular diseases are the major mortality cause in adult population (32%). The aim of our research is to investigate the association of genes cluster APOA-I/CIII/AIV/AV polymorphisms as well as PPAR polymorphisms with age-related conditions and with many laboratory exams in a Brazilian elderly cohort composed by 350 subjects. This genetics-epidemiology approach is original for Brazilian population. The following age-related conditions have been investigated: myocardial infarction and/or coronary heart disease, cerebrovascular disease and/or transitory ischaemic attack, hypertension, obesity, type 2 diabetes, low cognitive level (dementia), depression and neoplasia. The following laboratory exams have been studied: lipid and fractions, albumin, creatinin, urea, glycated hemoglobin and fasting glucose. Gene polymorphisms will be investigated by PCR-RFLP. Genes frequencies will be determined in this cohor and Hardy-Weinberg equilibrium will be tested. The identification of genetic risk factors may contribute to diagnosis, prognosis, prevention and treatment for age-related diseases in Brazilian elderly population as well as to a better understanding of the physiopathological role of these polymorphisms. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RASMUSSEN, LUCAS; DELABIO, ROGER; HORIGUCHI, LIE; MIZUMOTO, IGOR; TERAZAKI, CARLOS-RENATO; MAZZOTTI, DIEGO; BERTOLUCCI, PAULO-HENRIQUE; PINHEL, MARCELA-AUGUSTA; SOUZA, DOROTEIA; KRIEGER, HENRIQUE; et al. Association Between Interleukin 6 Gene Haplotype and Alzheimer's Disease: A Brazilian Case-Control Study. JOURNAL OF ALZHEIMER'S DISEASE, v. 36, n. 4, p. 733-738, . (04/15273-3, 09/15857-9, 06/07240-3)
MARQUES PAYAO, SPENCER LUIZ; GONCALVES, GISELA MORAES; DE LABIO, ROGER WILLIAM; HORIGUCHI, LIE; MIZUMOTO, IGOR; RASMUSSEN, LUCAS TREVIZANI; DE SOUZA PINHEL, MARCELA AUGUSTA; SILVA SOUZA, DOROTEIA ROSSI; BECHARA, MARCELO DIB; CHEN, ELIZABETH; et al. Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease. Journal of Neuroimmunology, v. 247, n. 1-2, p. 59-62, . (04/15273-3, 09/15857-9, 06/07240-3)

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