Apolipoproteins have na important role in lipid metabolism. Some genetic polymorphisms have been associated with age-related conditions, such as cardiovascular diseases and atherosclerosis. Transcription factors such as peroxysome proliferator-activated receptor (PPAR) have a marked effect on lipids metabolism. APO A-V gene is a target for PPAR in reducing TG levels. Cardiovascular diseases are the major mortality cause in adult population (32%). The aim of our research is to investigate the association of genes cluster APOA-I/CIII/AIV/AV polymorphisms as well as PPAR polymorphisms with age-related conditions and with many laboratory exams in a Brazilian elderly cohort composed by 350 subjects. This genetics-epidemiology approach is original for Brazilian population. The following age-related conditions have been investigated: myocardial infarction and/or coronary heart disease, cerebrovascular disease and/or transitory ischaemic attack, hypertension, obesity, type 2 diabetes, low cognitive level (dementia), depression and neoplasia. The following laboratory exams have been studied: lipid and fractions, albumin, creatinin, urea, glycated hemoglobin and fasting glucose. Gene polymorphisms will be investigated by PCR-RFLP. Genes frequencies will be determined in this cohor and Hardy-Weinberg equilibrium will be tested. The identification of genetic risk factors may contribute to diagnosis, prognosis, prevention and treatment for age-related diseases in Brazilian elderly population as well as to a better understanding of the physiopathological role of these polymorphisms. (AU)
Articles published in Agência FAPESP Newsletter about the research grant:
MARQUES PAYAO, SPENCER LUIZ;
GONCALVES, GISELA MORAES;
DE LABIO, ROGER WILLIAM;
RASMUSSEN, LUCAS TREVIZANI;
DE SOUZA PINHEL, MARCELA AUGUSTA;
SILVA SOUZA, DOROTEIA ROSSI;
BECHARA, MARCELO DIB;
MAZZOTTI, DIEGO ROBLES;
FERREIRA BERTOLUCCI, PAULO HENRIQUE;
CARDOSO SMITH, MARILIA DE ARRUDA.
Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease.
Journal of Neuroimmunology,
JUN 15 2012.
Web of Science Citations: 17.
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