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Liver resection for colorectal cancer metastasis: evaluation of linphonodal hilar micrometastasis: a prospective study

Grant number: 07/05109-0
Support type:Regular Research Grants
Duration: November 01, 2007 - October 31, 2009
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Paulo Herman
Grantee:Paulo Herman
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


For the great majority of authors, hilar limphnode metastasis constitutes a contraindication for liver resection, however, few studies had evaluated the standard of limphnodes micrometastasis during hepatectomy in patients whithout preoperative radiologic evidence or intraoperative macrocospic findings of limphnode metastasis. Objective: To analyze the prevalence and characteristics of hepatic hilum limphonodal micrometastasis in patients submitted to liver resection for colorectal metastasis; Correlate the clinical and pathological data with the standard of linfonodal micrometastasis, in order to define factors that can predict an increase of its prevalence. Causistic and methods: Patients with coloretal cancer metastasis submitted to liver resection will be prospectively studied. Preoperative evaluation will be carried out with liver function tests and tumour markers. Patients will also be submitted to radiologic staging with thoracic and abdominal CT scan and colonoscopy if indicated. Will be enclosed patients with good clinical conditions and normal liver function, after the control of primary disease and absence of extrahepatic metastasis. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIANA, E. F.; HERMAN, P.; SIQUEIRA, S. C.; TAKA, T.; CARVALHO, P.; COELHO, F. F.; PUGLIESE, V.; SAAD, W. A.; D'ALBUQUERQUE, L. A. C. Lymphadenectomy in Colorectal Cancer Liver Metastases Resection: Incidence of Hilar Limph Nodes Micrometastasis. JOURNAL OF SURGICAL ONCOLOGY, v. 100, n. 7, p. 534-537, DEC 1 2009. Web of Science Citations: 11.

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