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Development of versatile supramolecular polymeric systems for controlled release of antitumoral agents

Abstract

The proposed topic is inserted in the "Colloids and Interfaces" research area. The main objectives are focused on the preparation of nanostructured supramolecular polymeric systems and their use in the nanomedicine field. The investigations will be fundamentally divided in three steps: 1) Preparation and evaluation of the structure and dynamics of versatile micellar systems (mixed corona micelles) in different environmental conditions; 2) Evaluation of their potential as drug carrier and controlled release of therapeutical agents; 3) Investigations related to the interaction of the self-organized polymeric systems with biological fluids (proteins). The proposed subject will lead to an in-depth understanding on the preparation of the nanostructured entities based on block copolymer materials, and will guide to the development of manpower with multi and interdisciplinary knowledge enabled to teach and to lead projects in the main area of "Colloids and Interfaces". To the end, they will have a solid scientific knowledge in scattering methods (mainly light scattering). (AU)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DAL BO, ALEXANDRE G.; SOLDI, VALDIR; GIACOMELLI, FERNANDO C.; TRAVELET, CHRISTOPHE; BORSALI, REDOUANE; FORT, SEBASTIEN. Synthesis, micellization and lectin binding of new glycosurfactants. Carbohydrate Research, v. 397, p. 31-36, OCT 9 2014. Web of Science Citations: 8.
JAEGER, ELIEZER; JAEGER, ALESSANDRO; CHYTIL, PETR; ETRYCH, TOMAS; RIHOVA, BLANKA; GIACOMELLI, FERNANDO CARLOS; STEPANEK, PETR; ULBRICH, KAREL. Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester. JOURNAL OF CONTROLLED RELEASE, v. 165, n. 2, p. 153-161, JAN 28 2013. Web of Science Citations: 46.
DAL BO, ALEXANDRE G.; SOLDI, VALDIR; GIACOMELLI, FERNANDO C.; TRAVELET, CHRISTOPHE; JEAN, BRUNO; PIGNOT-PAINTRAND, ISABELLE; BORSALI, REDOUANE; FORT, SEBASTIEN. Self-Assembly of Amphiphilic Glycoconjugates into Lectin-Adhesive Nanoparticles. Langmuir, v. 28, n. 2, p. 1418-1426, JAN 17 2012. Web of Science Citations: 25.
GIACOMELLI, FERNANDO C.; STEPANEK, PETR; SCHMIDT, VANESSA; JAEGER, ELIEZER; JAEGER, ALESSANDRO; GIACOMELLI, CRISTIANO. Light scattering evidence of selective protein fouling on biocompatible block copolymer micelles. NANOSCALE, v. 4, n. 15, p. 4504-4514, 2012. Web of Science Citations: 15.
JAEGER, ALESSANDRO; GROMADZKI, DANIEL; JAEGER, ELIEZER; GIACOMELLI, FERNANDO CARLOS; KOZLOWSKA, AGNIESZKA; KOBERA, LIBOR; BRUS, JIRI; RIHOVA, BLANKA; EL FRAY, MIROSLAWA; ULBRICH, KAREL; STEPANEK, PETR. Novel ``soft{''} biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system. SOFT MATTER, v. 8, n. 16, p. 4343-4354, 2012. Web of Science Citations: 33.
JAEGER, ELIEZER; JAEGER, ALESSANDRO; ETRYCH, TOMAS; GIACOMELLI, FERNANDO CARLOS; CHYTIL, PETR; JIGOUNOV, ALEXANDER; PUTAUX, JEAN-LUC; RIHOVA, BLANKA; ULBRICH, KAREL; STEPANEK, PETR. Self-assembly of biodegradable copolyester and reactive HPMA-based polymers into nanoparticles as an alternative stealth drug delivery system. SOFT MATTER, v. 8, n. 37, p. 9563-9575, 2012. Web of Science Citations: 31.
DAL BO, ALEXANDRE G.; SOLDI, VALDIR; GIACOMELLI, FERNANDO C.; JEAN, BRUNO; PIGNOT-PAINTRAND, ISABELLE; BORSALI, REDOUANE; FORT, SEBASTIEN. Self-assembled carbohydrate-based micelles for lectin targeting. SOFT MATTER, v. 7, n. 7, p. 3453-3461, 2011. Web of Science Citations: 14.
FELIPPE, ARLINDO C.; BELLETTINI, ISMAEL C.; EISING, RENATO; MINATTI, EDSON; GIACOMELLI, FERNANDO C. Supramolecular Complexes Formed by the Association of Poly(ethyleneimine) (PEI), Sodium Cholate (NaC) and Sodium Dodecyl Sulfate (SDS). Journal of the Brazilian Chemical Society, v. 22, n. 8, p. 1539-1548, 2011. Web of Science Citations: 14.
GIACOMELLI, FERNANDO C.; STEPANEK, PETR; GIACOMELLI, CRISTIANO; SCHMIDT, VANESSA; JAEGER, ELIEZER; JAEGER, ALESSANDRO; ULBRICH, KAREL. pH-triggered block copolymer micelles based on a pH-responsive PDPA (poly[2-(diisopropylamino)ethyl methacrylate])inner core and a PEO (poly(ethylene oxide)) outer shell as a potential tool for the cancer therapy. SOFT MATTER, v. 7, n. 19, p. 9316-9325, 2011. Web of Science Citations: 50.

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