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Influence of spironolactone on cardiac remodeling induced by tobacco smoke

Grant number: 10/10187-2
Support type:Regular Research Grants
Duration: August 01, 2010 - July 31, 2011
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Marcos Ferreira Minicucci
Grantee:Marcos Ferreira Minicucci
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Assoc. researchers:Beatriz Bojikian Matsubara ; Leonardo Antonio Mamede Zornoff ; Luiz Shiguero Matsubara ; Paula Schmidt Azevedo Gaiolla ; Sergio Alberto Rupp de Paiva

Abstract

In addition to the well known vascular effects of tobacco, some studies suggest that this exposure could induce ventricular remodeling. Tobacco smoke exposure results in left ventricular enlargement and hypertrophy, systolic and diastolic dysfunction evaluated by in vivo and in vitro techniques. The mechanisms involved in this remodeling process are not completely known, and the role of inflammation and renin-angiotensin-aldosterone system (RAAS) on cardiac remodeling induced by tobacco smoke exposure was not study yet. RAAS blockade with aldosterone blockers, as spironolactone, have been studied in different models of ventricular remodeling. Recently their use is recommended by American Heart Association for patients with systolic dysfunction and heart failure with NYHA class III and IV, and for systolic dysfunction after myocardial infarction. Potential effects of aldosterone blockers are myocardial inflammation and hypertrophy attenuation. Thus our hypothesis is that spironolactone could attenuate remodeling process induced by tobacco smoke exposure, through the reduction of myocardial inflammation and hypertrophy. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, PRISCILA P.; NOGUEIRA, BRUNA F.; RAFACHO, BRUNA P. M.; AZEVEDO, PAULA S.; POLEGATO, BERTHA F.; CHIUSO-MINICUCCI, FERNANDA; BONOMO, CAMILA; ROSCANI, MELIZA G.; ZORZELLA-PEZAVENTO, SOFIA F. G.; TANNI, SUZANA E.; PEREIRA, ELENIZE J.; OKOSHI, MARINA P.; PAIVA, SERGIO A. R.; ZORNOFF, LEONARDO A. M.; MINICUCCI, MARCOS F. Aldosterone is not Involved in the Ventricular Remodeling Process Induced by Tobacco Smoke Exposure. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 30, n. 5, p. 1191-1201, 2012. Web of Science Citations: 6.

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