Dosage of cotinine in passive smoking children undergoing anesthesia and its correlation with respiratory complications

• Grant number: 10/08564-2
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2010
• End date: June 30, 2012
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Norma Sueli Pinheiro Módolo
• Grantee: Norma Sueli Pinheiro Módolo
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The cigarette is the second Major Cause of death not the World. In Brazil, 80 to 100 000 people die annually from diseases related to smoking. Various organs and systems are damaged "At OSU Continuous smoke, which contains over four thousand substances Composing a smoke, some of Pharmacological Action What They feature active, cytotoxic, antigen, mutagenic, including" At Least Forty-Three carcinogens. The organs most affected are the heart, gastrointestinal tract, lungs, blood and nervous systems and imunonóligo. Featured Special HAS the respiratory system, the condition receives directly inhaled gases. Individuals considered passive smokers ten Increased levels of COHb, as well as Greater airway reactivity. Infants and Young Children are more susceptible, compared to an adult, the reduction in functional residual capacity and airway closure hiccup general anesthesia. Patients suffering from smokers Degree Major in postoperative hypoxemia Value Non-smokers after similar anesthesia and surgery. What children are passive smokers presented abnormal airway responsiveness, as well as in pulmonary function tests. The frequency and intensity of respiratory disorders demonstrated in small passive smokers with a ten Value Direct Strength USE YOUR households make up in smoke. There is a tendency to underestimation of Children's Exposure to cigarette smoke when based only no reports of parents / caregivers OU, paragraph Especially when there is social pressure extinguishing of smoking. In this regard, cotinine, a metabolite of nicotine Major, has been used as a marker of smoking. Saliva HAS Advantage As a convenience and ease of retrieval of the sample. The goal of this research is to evaluate, in patients at five hundred to eighteen years of age, IF THERE IS AN Increased Incidence of respiratory complications when positions considered passive smokers undergoing general anesthesia in Relation AoS not regularly exposed to cigarette smoke. The Definition of passive smoking will be through the salivary cotinine. (AU)