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Acid ellagic derivatives in Brazilian foods: structural identification and bioavailability

Grant number: 07/05823-4
Support type:Regular Research Grants
Duration: February 01, 2008 - January 31, 2010
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal Investigator:Maria Ines Genovese Rodriguez
Grantee:Maria Ines Genovese Rodriguez
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil


There are no reports about the presence and characterization of ellagic acid derivatives in Brazilian foods, in spite of their nutritional importance. Besides, very little is known about their bioavailability and metabolism and the effects they could have on the antioxidant status in vivo when present in the diet. The objectives of this project are the screening of free and total ellagic acid in fruits and nuts cultivated in Brazil; the posterior characterization of potential sources in terms of vitamin C, flavonoids and total phenolics contents, and in vitro antioxidant capacity; the structural characterization of the ellagic acid derivatives by means of HPLC/DAD and LC-MS/MS; the determination of their bioavailability and the effect on the antioxidant status in vivo. (AU)