| Grant number: | 08/09294-9 |
| Support Opportunities: | Regular Research Grants |
| Start date: | September 01, 2009 |
| End date: | August 31, 2011 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal Investigator: | Daniel Guimarães Tiezzi |
| Grantee: | Daniel Guimarães Tiezzi |
| Host Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| City of the host institution: | Ribeirão Preto |
Abstract
The breast cancer is the most common and lethal malignant neoplasm, affecting people worldwide. Studies have showed that the rupture of basal membrane and the myoepithelial cells layer is a precocious sign of a clone cells formation responsible for the process of invasion. To infiltrate the stroma and to access the lymphatic and blood vessels, malignant epithelial cells must deactivate cell-to-cell adhesion mechanisms and acquire locomotive properties. This biological phenomenon has been reported as epithelial-mesenchymal transition (EMT). Genes first described as important in the control of embryogenesis as Twist-1 and Snail-2 (Slug) have been described as important factors of the breast cancer prognostic and progression. The activation of transcription factors Twist and Snail can induce genetic alteration in differentiated mammary epithelial cells leading to a specific phenotype that resembles a primordial cell (CD133+) described as cancer stem cell (CSC). The identification of specific CSC proteins expression as well as the overexpression of Twist transcription factors in areas of initial invasion can supply unknown information about the mechanisms of invasion and metastasis in breast cancer. (AU)
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