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Incidence of vertebral fractures and non-vertebral clinical fractures in a population of individuals aged 65 or more

Grant number: 09/15346-4
Support Opportunities:Regular Research Grants
Duration: April 01, 2010 - March 31, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Rosa Maria Rodrigues Pereira
Grantee:Rosa Maria Rodrigues Pereira
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Osteoporosis, although a global problem of public health, in part due to the increase in the number of people aged more than 65 years, is still largely neglected in developing countries. Besides the bone mineral density (BMD) obtained by densitometry, several clinical factors are identified as associated with increased risk of this disease. Aiming to better predict the risk of fractures in men and women, John Kanis recently started a project to develop a tool for tracking the risk of fracture (FRAX). FRAXTM was developed with support from the World Health Organization, with the participation of other institutions such as the International Osteoporosis Foundation, National Osteoporosis Foundation, International Society for Clinical densitometry and American Society for Bone and Mineral Research. The purpose of this tool is to identify individuals with low BMD (T-score between -1 and -2.5) have high risk of fracture, and therefore would benefit from treatment for osteoporosis. This instrument has been widely used in the world helping the physician in his decision to treat or not the patient at risk for fracture. For correct application of FRAX, each country should meet its epidemiology for fractures related to osteoporosis and its outcomes, and mortality rates. Accordingly, from the original work of Kanis et al. in the United Kingdom FRAX has been adapted for several other countries, but not in Brazilian population. This project aims to conduct a study of the incidence of vertebral fractures, no clinical vertebral fractures and mortality in a sample of elderly of our population, whose prevalence of fractures and osteoporosis was previously studied (FAPESP # 03/09313-0). In addition, to analyze the risk factors for fractures (age, age at menopause, smoking, alcohol, physical activity, calcium intake, family history of OP, glucocorticoids, falls, etc) in these individuals and from these data we will validate a version the FRAX (WHO Fracture Risk Assessment Tool) for the Brazilian population. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOMICIANO, DIOGO S.; MACHADO, LUANA G.; LOPES, JAQUELINE B.; FIGUEIREDO, CAMILLE P.; CAPARBO, VALERIA F.; OLIVEIRA, RICARDO M.; SCAZUFCA, MARCIA; MCCLUNG, MICHAEL R.; PEREIRA, ROSA M. R.. Bone Mineral Density and Parathyroid Hormone as Independent Risk Factors for Mortality in Community-Dwelling Older Adults: A Population-Based Prospective Cohort Study in Brazil. The SAo Paulo Ageing & Health (SPAH) Study. Journal of Bone and Mineral Research, v. 31, n. 6, p. 1146-1157, . (09/15346-4, 03/09313-0, 04/12694-8, 11/00411-5)
DE SANTANA, FELIPE M.; DOMICIANO, DIOGO S.; GONCALVES, MICHEL A.; MACHADO, LUANA G.; FIGUEIREDO, CAMILLE P.; LOPES, JAQUELINE B.; CAPARBO, VALERIA F.; TAKAYAMA, LILLIAM; MENEZES, PAULO R.; PEREIRA, ROSA M. R.. Association of Appendicular Lean Mass, and Subcutaneous and Visceral Adipose Tissue With Mortality in Older Brazilians: The Sao Paulo Ageing & Health Study. Journal of Bone and Mineral Research, v. 34, n. 7, p. 1264-1274, . (09/15346-4, 03/09313-0, 04/12694-8, 11/00411-5)
MACHADO, KETTY L. L. L.; DOMICIANO, DIOGO S.; MACHADO, LUANA G.; LOPES, JAQUELINE B.; FIGUEIREDO, CAMILLE P.; CAPARBO, VALERIA F.; TAKAYAMA, LILIAM; MENEZES, PAULO R.; PEREIRA, ROSA M. R.. Risk Factors for Low Muscle Mass in a Population-based Prospective Cohort of Brazilian Community-dwelling Older Women: The Sao Paulo Ageing & Health (SPAH) Study. JOURNAL OF CLINICAL DENSITOMETRY, v. 23, n. 3, p. 8-pg., . (04/12694-8, 03/09313-0, 09/15346-4)
PEREIRA, ROSA MARIA R.; FREITAS, THIAGO QUADRANTE; FRANCO, ANDRE SILVA; TAKAYAMA, LILIAM; CAPARBO, VALERIA F.; DOMICIANO, DIOGO S.; MACHADO, LUANA G.; FIGUEIREDO, CAMILLE P.; MENEZES, PAULO R.; ONUCHIC, LUIZ FERNANDO; et al. KLOTHO polymorphisms and age-related outcomes in community-dwelling older subjects: The SAo Paulo Ageing & Health (SPAH) Study. SCIENTIFIC REPORTS, v. 10, n. 1, . (11/00411-5, 03/09313-0, 09/15346-4, 04/12694-8)
MACHADO, L. G.; DOMICIANO, D. S.; FIGUEIREDO, C. P.; CAPARBO, V. F.; TAKAYAMA, L.; OLIVEIRA, R. M.; LOPES, J. B.; MENEZES, P. R.; PEREIRA, R. M. R.. Visceral fat measured by DXA is associated with increased risk of non-spine fractures in nonobese elderly women: a population-based prospective cohort analysis from the So Paulo Ageing & Health (SPAH) Study. OSTEOPOROSIS INTERNATIONAL, v. 27, n. 12, p. 3525-3533, . (09/15346-4, 04/12694-8)
DOMICIANO, D. S.; MACHADO, L. G.; LOPES, J. B.; FIGUEIREDO, C. P.; CAPARBO, V. F.; TAKAYAMA, L.; OLIVEIRA, R. M.; MENEZES, P. R.; PEREIRA, R. M. R.. Incidence and risk factors for osteoporotic vertebral fracture in low-income community-dwelling elderly: a population-based prospective cohort study in Brazil. The So Paulo Ageing & Health (SPAH) Study. OSTEOPOROSIS INTERNATIONAL, v. 25, n. 12, p. 2805-2815, . (09/15346-4, 03/09313-0, 04/12694-8)
MACHADO, K. L. L. L.; DOMICIANO, D. S.; MACHADO, L. G.; LOPES, J. B.; FIGUEIREDO, C. P.; TAKAYAMA, L.; OLIVEIRA, R. M.; MENEZES, P. R.; PEREIRA, R. M. R.. Persistent hypovitaminosis D and loss of hip bone mineral density over time as additional risk factors for recurrent falls in a population-based prospective cohort of elderly persons living in the community. The Sao Paulo Ageing & Health (SPAH) Study. OSTEOPOROSIS INTERNATIONAL, v. 26, n. 5, p. 1535-1542, . (09/15346-4, 03/09313-0, 04/12694-8)

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