Plasticidade muscular esqueletica apos injuria e atrofia: influencia das proteinas de choque termico.

• Grant number: 09/53528-7
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2010
• End date: September 30, 2012
• Field of knowledge: Biological Sciences - Morphology - Histology
• Principal Investigator: Elen Haruka Miyabara
• Grantee: Elen Haruka Miyabara
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo

Abstract

It is well known that heat shock proteins (HSPs) have a crucial cytoprotective role against several noxious stimuli. It has been demonstrated that inducible HSP70 (HSP70i) exerts important protection of skeletal muscles against lengthening contraction injury and freezing. However, the influence of HSPs in skeletal muscle regeneration and atrophy and subsequent recovery from atrophy is not well known, a few studies are related to this issue showing that the HSPs induction by radicicol in skeletal muscle is able to improve skeletal muscle tissue regeneration (Conte et al., 2008), though the intracellular mechanisms involved in this process have not been explored yet. Furthermore, the induction of HSPs by elevated temperature is able to attenuate the skeletal muscle atrophy and to stimulate protein synthesis (Naito et al., 2000). Considering that 1) more efficient therapeutic strategies in order to prevent the deleterious effects upon the skeletal muscle could be extremely interesting in situation of reduced demand (skeletal muscle disuse) and increased demand (recovery of muscle mass after injury and long periods of immobilization) respectively; and 2) the HSP induction has been conferred a protection and/or improved recovery of several cell types; we purpose to investigate the effect of HSP induction (by using radicicol pharmacologic induction and over expressing HSP70Í transgenic mice) on prevention against muscle atrophy and on recovery of skeletal muscle after injury and atrophy. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

NASCIMENTO, T. L.; CONTE, T. C.; RISSATO, T. S.; LUNA, M. S.; SOARES, A. G.; MORISCOT, A. S.; YAMANOUYE, N.; MIYABARA, E. H.. Radicicol enhances the regeneration of skeletal muscle injured by crotoxin via decrease of NF-kB activation. Toxicon, v. 167, p. 6-9, SEP 2019. (13/04783-0, 12/21238-2, 09/53528-7)

SILVA, M. T.; WENSING, L. A.; BRUM, P. C.; CAMARA, N. O.; MIYABARA, E. H.. Impaired structural and functional regeneration of skeletal muscles from beta 2-adrenoceptor knockout mice. ACTA PHYSIOLOGICA, v. 211, n. 4, p. 617-633, AUG 2014. (12/21238-2, 09/53528-7, 09/12593-0)

CONTE, TALITA C.; SILVA, LUCILA H.; SILVA, MEIRICRIS T.; HIRABARA, SANDRO M.; OLIVEIRA, ANTONIO C.; CURI, RUI; MORISCOT, ANSELMO S.; AOKI, MARCELO S.; MIYABARA, ELEN H.. The beta 2-Adrenoceptor Agonist Formoterol Improves Structural and Functional Regenerative Capacity of Skeletal Muscles From Aged Rat at the Early Stages of Postinjury. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v. 67, n. 5, p. 443-455, MAY 2012. (09/53528-7, 09/17667-2, 09/12593-0)