Factors related to HPV infection and cell proliferation that could be predictive of the evolution of cervical intraepithelial neoplasia (CIN 2) in women followed up with colposcopy and cytology

• Grant number: 10/07880-8
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2010
• End date: July 31, 2012
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Luiz Carlos Zeferino
• Grantee: Luiz Carlos Zeferino
• Host Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Lara Termini ; Luisa Lina Villa ; Silvia Helena Rabelo dos Santos

Abstract

In 2005, we began a study to assess the evolution of cervical intraepithelial neoplasia grade 2 (CIN 2) confirmed by biopsy. This study is a cohort comprising 45 women who have completed the follow-up that was controlled until 12 months. The objective will be to identify markers related to HPV infection (specific types, variants, viral load and integration) and related to cell proliferation (expression of p16, hK7 SOD2 proteins) that could be predictive of disease progression or regression. The women object of this study had screening cytology suggestive of atypical squamous cells of undetermined significance (ASC-US) or low grade squamous intraepithelial lesion (LSIL) and biopsy proven CIN 2. The sample size was calculated in 45 women, based on alpha error of 0.05 and beta of 0.20. The analysis will be performed using chi-square and p-value to test the associations between the variables and odds ratios (OR) with their respective 95% confidence intervals (95%CI) to estimate the magnitude of association. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DISCACCIATI, MICHELLE G.; DE SOUZA, CARLOS ANDRE S.; D'OTAVIANNO, MARIA GABRIELA; ANGELO-ANDRADE, LILIANA A. L.; WESTIN, MARIA CRISTINA A.; RABELO-SANTOS, SILVIA H.; ZEFERINO, LUIZ C.. Outcome of expectant management of cervical intraepithelial neoplasia grade 2 in women followed for 12 months. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, v. 155, n. 2, p. 204-208, APR 2011. (10/07880-8)

LOFFREDO D'OTTAVIANO, MARIA GABRIELA; DISCACCIATI, MICHELLE GARCIA; ANDREOLI, MARIA ANTONIETA; COSTA, MARIA CECELIA; TERMINI, LARA; RABELO-SANTOS, SILVIA H.; VILLA, LUISA LINA; ZEFERINO, LUIZ CARLOS. HPV 16 Is Related to the Progression of Cervical Intraepithelial Neoplasia Grade 2: A Case Series. OBSTETRICS AND GYNECOLOGY INTERNATIONAL, v. 2013, p. 5-pg., 2013-01-01. (10/07880-8)