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Investigation of the metabolite profile of cancer prostate biomarkers by capillary electrophoresis using a system biology approach

Grant number: 08/11195-9
Support type:Regular Research Grants
Duration: May 01, 2009 - April 30, 2012
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Cooperation agreement: NSF - American Universities (Chemistry)
Principal Investigator:Ana Valéria Colnaghi Simionato
Grantee:Ana Valéria Colnaghi Simionato
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The neoplasy incidence in the world population has caused an elevated obit number, independent on the age, sex, race or social class of the individuals. Therefore, a rapid and accurate disease diagnostic is required for a safe and appropriate treatment, as well as the reduction of obits. In this project, prostate cancer biomarkers will be investigated within the metabolic profile of patients and healthy volunteers, in a system biology approach. The interest in the metabolomic area resides in the complementarily information obtained from a single system towards the other "omics" areas (e.g. transcriptomics and proteomics). The metabolites, tumor biomarkers searched herein are modified nucleosides. The samples will be obtained from patients recently diagnosed with prostate cancer by biopsy. The control samples will be obtained from blood donors (healthy volunteers) in the University Blood Center. The obtained blood sera samples will be previously analyzed by the prostate specific antigen (PSA) immunoassays in the University Hospital. These samples will be analyzed by capillary electrophoresis after method development with modified nucleosides analytical standards. The obtained data will be evaluated by multivariate analyses in order to establish the prostate cancer biomarkers metabolite profile, as well as the disease stage, so that the immunoassay diagnostics may be either corroborated or contested. Therefore, this project is relevant due to its applicability in analytical chemistry and extreme importance to public health. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEITAO, AMANDA ARAUJO; MUNIZ DE LACERDA MIRANDA, PAULO CESAR; COLNAGHI SIMIONATO, ANA VALERIA. Simple and rapid CE-UV method for the assessment of trail pheromone compounds of leaf-cutting ants' venom glands. ELECTROPHORESIS, v. 32, n. 9, 1, SI, p. 1074-1079, APR 2011. Web of Science Citations: 2.

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