Angiogenic markers and utero- placental Doppler velocimetry in preeclamptic patients

• Grant number: 09/54729-6
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2010
• End date: May 31, 2012
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Silvia Daher
• Grantee: Silvia Daher
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Preeclampsia (PE) remains an important cause of maternal and perinatal mortality and morbidity.The physiopathology of PE involves complex mechanisms, including altered placental angiogenesis. Unbalanced levels of pro and anti angiogenic factors could cause endothelial lesion leading to the clinical manifestations that characterize PE. Increased secretion of soluble endoglin (sEng) and soluble tyrosine kinase (sFlt1) may increase vessel permeability and inhibit vascular growth. On the other hand, a decrease in the production of adiponectin and calcitonin may affect placental angiogenesis and neovascularization. Accordingly, altered levels of these mediators have been detected in patients with PE. Placental perfusion is reduced in women with PE. This can be evaluated through uterine artery Doppler velocimetry. Several studies have analyzed uterine artery Doppler velocimetry combined with biochemical parameters in the prediction of PE. Despite some controversies, the evaluation of a combination of different mediators seems to better reflect the level of vascular disturbance than their individual assessment. Therefore, aiming to contribute to a better understanding of the pathogenesis of PE, we will evaluate the serum levels of pro-angiogenic (calcitonin and adiponectin) and anti-angiogenic (sEng e sFlt1) factors and assess utero- placental perfusion through uterine and umbilical artery Doppler velocimetry in patients with PE compared to healthy women at the same gestational age. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TOBINAGA, CLARISSA M.; TORLONI, MARIA R.; GUEUVOGHLANIAN-SILVA, BARBARA Y.; PENDELOSKI, KAREN P. T.; AKITA, PATRICIA A.; SASS, NELSON; DAHER, SILVIA. Angiogenic factors and uterine Doppler velocimetry in early- and late- onset preeclampsia. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, v. 93, n. 5, p. 469-476, MAY 2014. (10/08082-8, 09/54729-6)