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Crack/cocaine chronic use: dopamine transporters availability, genetic factors, and executive functioning

Abstract

Neuroimage researches have show changes in the dopamine transporter (DAT) availability after cocaine chronic use. Genetic factors have been considered in vulnerability to addiction and executive functioning plays an important role in the urge to use the drug and the difficulties to leaving the use. Objective: To evaluate neuroanatomic integrity and DAT availability, correlating polymorphisms located in the gene SLC6A3 and the executive functioning in crack chronic users in current and abstinence use, compared with healthy controls. Methods: In a cross-sectional study with 150 users divided into 5 groups according to time of use and abstinence period and 50 controls will be submitted to functional neuroimaging (SPECT), magnetic resonance imaging, genetic analysis and neuropsychological assessment. Results: It is expected that: (1) crack chronic users show an increase in DAT availability in the striatum when compared to healthy controls and short-term users, (2) crack users have worse performance in executive functioning tests when compared to healthy controls and short-term users, (3) crack acute users (less than two years) abstinent six months show equal levels of DAT to the control group, (4) crack chronic users present orbitofrontal cortex volume reduction , and decreased corpus callosum integrity in its rostral subregions. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALMEIDA, PRISCILA P.; DE ARAUJO FILHO, GERARDO M.; MALTA, STELLA M.; LARANJEIRA, RONALDO R.; MARQUES, ANA CECILIA R. P.; BRESSAN, RODRIGO A.; LACERDA, ACIOLY L. T.. Attention and memory deficits in crack-cocaine users persist over four weeks of abstinence. JOURNAL OF SUBSTANCE ABUSE TREATMENT, v. 81, p. 73-78, . (08/09009-2)
LIBANIO, TANIA C.; EUFRASIO, RAI A.; NIIGAKI, SUZY S.; PERES, FERNANDA F.; SILVA, REGINA H.; ZUARDI, ANTONIO W.; HALLAK, JAIME E. C.; CRIPPA, JOSE A. S.; CALZAVARA, MARIANA B.; ABILIO, VANESSA C.. Harmine Impairs Memory Performance of Treated Rats and Nontreated Cagemates. EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, . (08/09009-2)
FALVELLA, ANA CAROLINE BRAMBILLA; SMITH, BRADLEY JOSEPH; SILVA-COSTA, LICIA C.; VALENCA, ALINE G. F.; CRUNFLI, FERNANDA; ZUARDI, ANTONIO W.; HALLAK, JAIME E.; CRIPPA, JOSE A.; ALMEIDA, VALERIA DE; MARTINS-DE-SOUZA, DANIEL. Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. FRONTIERS IN MOLECULAR NEUROSCIENCE, v. 14, . (18/03422-7, 08/09009-2, 17/18242-1, 19/00098-7, 17/25588-1, 19/22398-2, 18/10362-0, 18/03450-0, 18/03673-0)
JOSÉ A. CRIPPA; LUIZ C. PEREIRA JUNIOR; LÍVIA C. PEREIRA; PATRÍCIA M. ZIMMERMANN; LIBERATO BRUM JUNIOR; LETÍCIA M. RECHIA; ISABELLA DIAS; JAIME E. HALLAK; ALLINE C. CAMPOS; FRANCISCO S. GUIMARÃES; et al. Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters. Revista Brasileira de Psiquiatria, v. 44, n. 1, p. 15-20, . (08/09009-2)
PEREIRA, ANAMARIA FALCAO; PONTES LISBOA, MARIO ROBERTO; DE FREITAS ALVES, BRUNO WESLEY; PEREIRA DA SILVA, CRISTIANE MARIA; SOUZA DIAS, DIEGO BERNARDE; SANTOS DE MENEZES, KAROLINE LUANNE; SANTANA CESARIO, FRANCISCO RAFAEL ALVES; DE FRANCA, JONAS COSTA; DE OLIVEIRA, AMANDA ROCHA; CECILIO HALLAK, JAIME EDUARDO; et al. Endocannabinoid System Attenuates Oxaliplatin-Induced Peripheral Sensory Neuropathy Through the Activation of CB1 Receptors. NEUROTOXICITY RESEARCH, v. 39, n. 6, . (08/09009-2)
DE ALMEIDA, CARLOS M. O.; BRITO, MANUELINA M. C.; BOSAIPO, NAYANNE B.; PIMENTEL, ANGELA V.; TUMAS, VITOR; ZUARDI, ANTONIO W.; CRIPPA, JOSE A. S.; HALLAK, JAIME E. C.; ECKELI, ALAN L.. Cannabidiol for Rapid Eye Movement Sleep Behavior Disorder. MOVEMENT DISORDERS, v. 36, n. 7, p. 1711-1715, . (08/09009-2)
DE MENESES-GAYA, CAROLINA; CRIPPA, JOSE A.; HALLAK, JAIME E.; MIGUEL, ANDRE Q.; LARANJEIRA, RONALDO; BRESSAN, RODRIGO A.; ZUARDI, ANTONIO W.; LACERDA, ACIOLY L.. annabidiol for the treatment of crack-cocaine craving: an exploratory double-blind stud. Revista Brasileira de Psiquiatria, v. 43, n. 5, p. 467-476, . (08/09009-2)
CRIPPA, JOSE A.; JUNIOR, LUIZ C. PEREIRA; PEREIRA, LIVIA C.; ZIMMERMANN, PATRICIA M.; BRUM JUNIOR, LIBERATO; RECHIA, LETICIA M.; DIAS, ISABELLA; HALLAK, JAIME E.; CAMPOS, ALLINE C.; GUIMARAES, FRANCISCO S.; et al. ffect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matter. Revista Brasileira de Psiquiatria, v. 44, n. 1, p. 15-20, . (08/09009-2)
CRIPPA, JOSE ALEXANDRE S.; ZUARDI, ANTONIO W.; GUIMARAES, FRANCISCO S.; CAMPOS, ALLINE CRISTINA; OSORIO, FLAVIA DE LIMA; LOUREIRO, SONIA REGINA; DOS SANTOS, RAFAEL G.; SOUZA, JOSE DIOGO S.; USHIROHIRA, JULIANA MAYUMI; PACHECO, JULIA COZAR; et al. Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic A Randomized Clinical Trial. JAMA NETWORK OPEN, v. 4, n. 8, . (08/09009-2, 20/12110-9)
JOSÉ A. CRIPPA; LUIZ C. PEREIRA JUNIOR; LÍVIA C. PEREIRA; PATRÍCIA M. ZIMMERMANN; LIBERATO BRUM JUNIOR; LETÍCIA M. RECHIA; ISABELLA DIAS; JAIME E. HALLAK; ALLINE C. CAMPOS; FRANCISCO S. GUIMARÃES; et al. Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters. Revista Brasileira de Psiquiatria, n. ahead, p. -, . (08/09009-2)

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