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Venoms from neonate and mature Bothrops jararaca snakes: comparison between enzymatic and biological activities, immunoneutralization, chemical composition and ability to induce hemostatic disorders

Grant number: 08/02996-8
Support type:Regular Research Grants
Duration: November 01, 2008 - October 31, 2010
Field of knowledge:Biological Sciences - Pharmacology - Toxicology
Principal Investigator:Marcelo Larami Santoro
Grantee:Marcelo Larami Santoro
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTORO, MARCELO LARAMI; DO CARMO, THAIS; LOPES CUNHA, BRUNA HELOISA; ALVES, ANDRE FONSECA; ZELANIS, ANDRE; DE TOLEDO SERRANO, SOLANGE MARIA; GREGO, KATHLEEN FERNANDES; SANT'ANNA, SAVIO STEFANINI; BARBARO, KATIA CRISTINA; FERNANDES, WILSON. Ontogenetic Variation in Biological Activities of Venoms from Hybrids between Bothrops erythromelas and Bothrops neuwiedi Snakes. PLoS One, v. 10, n. 12 DEC 29 2015. Web of Science Citations: 5.
SENISE, LUANA V.; YAMASHITA, KARINE M.; SANTORO, MARCELO L. Bothrops jararaca envenomation: Pathogenesis of hemostatic disturbances and intravascular hemolysis. Experimental Biology and Medicine, v. 240, n. 11, p. 1528-1536, NOV 2015. Web of Science Citations: 10.
ELISA PEICHOTO, MARIA; ZYCHAR, BIANCA CESTARI; LUIZ TAVARES, FLAVIO; GONCALVES, LUIS ROBERTO CAMARGO; ACOSTA, OFELIA; SANTORO, MARCELO LARAMI. Inflammatory effects of patagonfibrase, a metalloproteinase from Philodryas patagoniensis (Patagonia Green Racer; Dipsadidae) venom. Experimental Biology and Medicine, v. 236, n. 10, p. 1166-1172, OCT 2011. Web of Science Citations: 10.
YAMASHITA, K. M.; NOGUEIRA, T. O.; SENISE, L. V.; CIRILLO, M. C.; GONCALVES, L. R. C.; SANO-MARTINS, I. S.; GIORGI, R.; SANTORO, M. L. Involvement of circulating platelets on the hyperalgesic response evoked by carrageenan and Bothrops jararaca snake venom. Journal of Thrombosis and Haemostasis, v. 9, n. 10, p. 2057-2066, OCT 2011. Web of Science Citations: 7.
ANTUNES, THATIANE C.; YAMASHITA, KARINE M.; BARBARO, KATIA C.; SAIKI, MITIKO; SANTORO, MARCELO L. Comparative analysis of newborn and adult Bothrops jararaca snake venoms. Toxicon, v. 56, n. 8, p. 1443-1458, DEC 2010. Web of Science Citations: 53.
PEICHOTO, MARIA E.; PAES LEME, ADRIANA F.; PAULETTI, BIANCA A.; BATISTA, ISABEL CORREIA; MACKESSY, STEPHEN P.; ACOSTA, OFELIA; SANTORO, MARCELO L. Autolysis at the disintegrin domain of patagonfibrase, a metalloproteinase from Philodryas patagoniensis (Patagonia Green Racer; Dipsadidae) venom. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1804, n. 9, p. 1937-1942, SEP 2010. Web of Science Citations: 14.
SEIBERT, CARLA SIMONE; SANTORO, MARCELO L.; TAMBOURGI, DENISE VILARINHO; SAMPAIO, SANDRA COCCUZZO; TAKAHASHI, HILTON KENJI; PERES, CARMEM MALDONADO; CURI, RUI; SANO-MARTINS, IDA S. Lonomia obliqua (Lepidoptera, Saturniidae) caterpillar bristle extract induces direct lysis by cleaving erythrocyte membrane glycoproteins. Toxicon, v. 55, n. 7, p. 1323-1330, JUN 15 2010. Web of Science Citations: 5.
PEICHOTO, MARIA E.; MACKESSY, STEPHEN P.; TEIBLER, PAMELA; TAVARES, FLAVIO L.; BURCKHARDT, PAULA L.; BRENO, MARIA C.; ACOSTA, OFELIA; SANTORO, MARCELO L. Purification and characterization of a cysteine-rich secretory protein from Philodryas patagoniensis snake venom. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v. 150, n. 1, p. 79-84, JUL 2009. Web of Science Citations: 29.

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