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Cardiovascular response during exercise treadmill test, peripheral vasodilatation, and genetic polymorphisms of alpha-adrenergic receptors and nitric oxide synthase enzyme in patients underwent cardiological examination

Grant number: 09/52992-1
Support type:Regular Research Grants
Duration: February 01, 2010 - January 31, 2012
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Alfredo José Mansur
Grantee:Alfredo José Mansur
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Background: individuals without overt heart disease may have different responses during exercise treadmill test. We formulate the hypothesis that cardiovascular response to exercise treadmill test may vary with peripheral vasodilatation capacity and with genetic polymorphisms of alpha-adrenergic receptors and endothelial nitric oxide synthase enzyme. Objectives: to evaluate the relation between cardiovascular response during exercise testing (functional capacity and, chronotropic and pressoric response), forearm vasodilatation by means of venous occlusion plethysmography and genetic polymorphisms of alpha-adrenergic receptors and endothelial nitric oxide synthase. Methods: 500 male and female subjects underwent to cardiologic examination that included medical examination, blood tests and exercise treadmill test. The peripheral vasodilatadory response will be estimated by forearm blood flow response at rest and during isometric exercise (handgrip maneauver). Blood samples will be collected for biochemistry analysis and determination of the following genetic polymorphisms: endotelial nitric oxide synthase enzyme (-786T/C e Glu298Arg), alphalA adrenergic receptor (Arg347Cys), alpha2A adrenergic receptor (Asn251Lys e C1291G), alpha2B adrenergic receptor (Ins/Del 301-303 e 12Glu9) and alpha2C adrenergic receptor (Del 322-325). (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BELO NUNES, RAFAEL AMORIM; LIMA, LARISSA BARBOSA; TANAKA, NELSON ITHIRO; PEREIRA, ALEXANDRE DA COSTA; KRIEGER, JOSE EDUARDO; MANSUR, ALFREDO JOSE. Genetic associations of bradykinin type 2 receptor, alpha-adrenoceptors and endothelial nitric oxide synthase with blood pressure and left ventricular mass in outpatients without overt heart disease. IJC HEART & VASCULATURE, v. 21, p. 45-49, DEC 2018. Web of Science Citations: 0.
BELO NUNES, RAFAEL AMORIM; BARROSO, LUCIA PEREIRA; PEREIRA, ALEXANDRE DA COSTA; PINTO BRANDAO RONDON, MARIA URBANA; NEGRAO, CARLOS EDUARDO; KRIEGER, JOSE EDUARDO; MANSUR, ALFREDO JOSE. Alpha2A-adrenergic receptor and eNOS genetic polymorphisms are associated with exercise muscle vasodilatation in apparently healthy individuals. IJC HEART & VASCULATURE, v. 13, p. 14-18, DEC 2016. Web of Science Citations: 1.
BELO NUNES, RAFAEL AMORIM; GIAMPAOLI, VIVIANA; GONCALVES DE FREITAS, HUMBERTO FELICIO; PEREIRA, ALEXANDRE DA COSTA; ARAUJO, FERNANDO; CORREIA, GUSTAVO FERREIRA; PINTO BRANDAO RONDON, MARIA URBANA; NEGRAO, CARLOS EDUARDO; MANSUR, ALFREDO JOSE. Exercise-Induced Muscle Vasodilatation and Treadmill Exercise Test Responses in Individuals without Overt Heart Disease. CARDIOLOGY, v. 127, n. 1, p. 38-44, 2014. Web of Science Citations: 2.
BELO NUNES, RAFAEL AMORIM; ARAUJO, FERNANDO; CORREIA, GUSTAVO F.; DA SILVA, GISELA T.; MANSUR, ALFREDO J. High-sensitivity C-reactive protein levels and treadmill exercise test responses in men and women without overt heart disease. EXPERIMENTAL & CLINICAL CARDIOLOGY, v. 18, n. 2, p. 124-128, SUM 2013. Web of Science Citations: 4.

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